1. Techno Drugs Ltd.
Welcome to the training program

2. Short –acting IV anesthetic
agent.
Propofol
Propofol BP

3. Product Profile:
• Brand Name: Propofol
• Generic Name: Propofol
• Therapeutic Class : Anesthesia
• Strength : 20 ml IV injection (10 mg/ml )

4. Description:
• Propofol® Injectable Emulsion is a sterile, non
pyrogenic emulsion containing 10 mg/ml of
propofol suitable for intravenous administration.
Propofol is slightly soluble in water and, thus, is
formulated in a white to light yellow, oil-in-water
emulsion. In addition to the active component,
Propofol®, the formulation also contains soybean
oil (100 mg/ml), glycerol (22.5 mg/ml), egg
lecithin (12 mg/ml) and disodium edetate (0.005%)
with sodium hydroxide to adjust pH.

5. Pharmacology:
Propofol® Injectable Emulsion is an IV sedative-
hypnotic agent for use in the induction and
maintenance of anesthesia or sedation.
IV injection of a therapeutic dose of propofol
induces hypnosis, with minimal excitation, usually
within 40 seconds from the start of injection (the
time for one arm-brain circulation). As with other
rapidly acting IV anesthetic agents, the half-time
of the blood-brain equilibration is approximately 1
to 3 minutes, accounting for the rate of induction
of anesthesia.

6. Mechanism of action:

7. When GABAA receptors are activated, trans membrane chloride
conductance increases, resulting in hyperpolarization of the
postsynaptic cell membrane and functional inhibition of the
postsynaptic neuron.

8. Indications:
Propofol® is a short-acting intravenous anesthetic
agent suitable for
• Induction and maintenance of general anesthesia.
• Sedation of ventilated patients receiving intensive
care.
• Monitored anesthesia care sedation for surgical
and diagnostic procedures.

9. Dosage & Administration:
Induction of General Anesthesia
Healthy Adults Less Than 55 Years of Age:
40 mg every 10 seconds until induction onset (2-2.5 mg/kg).
Elderly, Debilitated, or ASA III/IV Patients:
20 mg every 10 seconds until induction onset (1-1.5 mg/kg).
Cardiac Anesthesia:
20 mg every 10 seconds until induction onset (0.5-1.5 mg/kg).
Neurosurgical Patients:
20 mg every 10 seconds until induction onset (1-2 mg/kg).
Pediatric Patients - healthy, from 3-16 years of age:
2.5-3.5 mg/kg administered over 20-30 seconds.

10. Maintenance of General
Anesthesia
Healthy Adults Less Than 55 Years of Age:
100-200 μg/kg/min (6-12 mg/kg/h).
Elderly, Debilitated, ASA III/IV Patients:
50-100 μg/kg/min (3-6 mg/kg/h).
Pediatric Patients - healthy, 3 years to 16 years of age: 125-
300 μg/kg/min (7.5-18 mg/kg/h)
Cardiac Anesthesia, Most Patients Require:
Primary propofol injectable emulsion with secondary opioid:
100-150 μg/kg/min. Low-dose propofol injectable emulsion
with primary opioid: 50-100 μg/kg/min.
Neurosurgical Patients: 100-200 μg/kg/min (6-12 mg/kg/h).

11. Contraindication:
• Absolute contraindications: Patients with a known
hypersensitivity to propofol or any of its components;
allergies to eggs, egg products, soybeans or soy
products; disorders of fat metabolism.
• Relative contraindications: Patients undergoing
stereotactic neurosurgery such as pallidotomy, as it
temporary abolishes tremors in patients with
Parkinsonism; Known case of Epilepsy; Untreated
hypertensive, compromised Left ventricle function;
Hepatic or Renal impairment; Pregnant and lactating
mother; Paediatric patients age < 3 years.

12. Advantages of propofol:
1. Rapid & smooth Recovery.
2. Completed eliminated from body in 4 hours so
patient is ambulatory early.
3. Anti-Emetic.
4. Anti-Pruritic.
5. Bronchodilator.

13. Competitors:
Brand Name Contains
Dosage
Form
Manufactur
er
Price(Tk.)
FRESOFOL
Propofol
10mg/ml
Injection
Fresenius
Kabi/Hye
Impex
20ml amp x
5s pack:
1758.00
MRP; 50ml
bot x 1s
pack: 779.00
MRP
POFOL I.V
Propofol
10mg/ml
i.v Injection
Popular
Pharmaceut
icals Ltd.
20ml amp x
1s pack:
200.00 MRP
RECOFOL
Propofol
10mg/ml
Injection
Bayer
Schering
Oy/ Tajarat
20ml amp x
1s pack:
MRP; 50ml
vial x 1s
pack:

14. Thank you