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Quantifying Parkinson's Disease with a Wii

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Quantifying Your Parkinson’s
          with a Wii
     QuantifiedSelf Paris May 22, 2012




   2012 FundMyMedicalResearch...

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Parkinson’s Disease
A brief introduction

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What is Parkinson’s Disease?
 Neurological degeneration of substantia nigra’s cells
    Cells producing dopamine
    Di...

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Quantifying Parkinson's Disease with a Wii

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The advent of unexpensive mutlipurpose devices like the Wii, the Kinect, the iPhone, and other motion capturing devices have opened up the opportunity for patients to track with objective measures the evolution and treatment of their Parkinson's Disease. Beyond this QuantifiedSelf approach, this have also created the possibility to run simple clinical trials at a very low cost, that could be funded thanks to the new crowdfunding approach.

The advent of unexpensive mutlipurpose devices like the Wii, the Kinect, the iPhone, and other motion capturing devices have opened up the opportunity for patients to track with objective measures the evolution and treatment of their Parkinson's Disease. Beyond this QuantifiedSelf approach, this have also created the possibility to run simple clinical trials at a very low cost, that could be funded thanks to the new crowdfunding approach.

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Quantifying Parkinson's Disease with a Wii

  1. 1. Quantifying Your Parkinson’s with a Wii QuantifiedSelf Paris May 22, 2012 2012 FundMyMedicalResearch.org – http://twitter.com/FundMyMR CC BY-NC-ND
  2. 2. Parkinson’s Disease A brief introduction
  3. 3. What is Parkinson’s Disease?  Neurological degeneration of substantia nigra’s cells  Cells producing dopamine  Disease characterized by tremors, bradykinesia (slowness), rigidity  Diagnostic is currently only clinical (observation)  DaTScan can spot dopaminergic deficits and help differentiate with other disorders but is not an official base for a diagnostic  Only evaluation by a neurologist is recognized for diagnosis  Looking for biomarkers – PPMI Michael J Fox Foundation’s initiative  DatScan measures?  Cerebral Spinal Fluid analysis?  Blood levels? 2012 FundMyMedicalResearch.org – http://twitter.com/FundMyMR CC BY-NC-ND
  4. 4. Causes of Parkinson’s  We don’t know!  But we know that  Dopamine producing cells in the Substantia Nigra (SN) degenerate  Basal ganglia cells do not receive enough dopamine and can’t perform their complex job for motor, and mood, processing loops  Motor alterations of movements is more and more pronounced, “potentially” until a bed-ridden stage  “Usually” leading to a constant degradation in Quality of Life 2012 FundMyMedicalResearch.org – http://twitter.com/FundMyMR CC BY-NC-ND
  5. 5. What’s the treatment?  Compensate the loss of dopamine by supplying more levodopa, a precursor that is transformed in dopamine by the Substantia Nigra cells  Though, we can’t monitor directly the number of SN cells  We could see, thanks to a heavy procedure (DaTScan), the uptake of dopamine in basal ganglia improving  But mainly, we can see the improvement in motor condition  Which is the basis for an official diagnosis  Exercise is also shown to be important (as potent as dopamine agonists, another drug class)  “Use it or loose it” situation  Probably improves uptake of dopamine  Put neuroplasticity in motion 2012 FundMyMedicalResearch.org – http://twitter.com/FundMyMR CC BY-NC-ND
  6. 6. The situation is  Motor symptoms are the only easily observable impact of the disease  Depression is difficult to evaluate, and can be made worse by motor problems  Every Parkinson’s patient is different  Mechanisms are extremely complex and idiopathies probably very different  Symptoms vary greatly among patients  Levodopa has a short plasma half-life cycle (1 hour)  Should be taken several times a day  Proper doses throughout the day and adherence to schedule are critical 2012 FundMyMedicalResearch.org – http://twitter.com/FundMyMR CC BY-NC-ND
  7. 7. Why the Wii (or the Kinect, or the iPhone,..) can help?  Helps you exercising  Monitors your movements  Provides measures or indexes that you can track (e.g. Wii-Fit age)  Several studies are built on using the Wii to create physical exercises, and monitor their impact  Wii has been an early (objective) indicator for a UK lady prior to her diagnosis  Wii could serve to quantify objective measures among a large set of patients, and control group 2012 FundMyMedicalResearch.org – http://twitter.com/FundMyMR CC BY-NC-ND
  8. 8. Sara Riggare A woman with Parkinson’s Disease. Not patient but im-patient
  9. 9. 2012 Sara Riggare – http://twitter.com/SaraRiggare CC BY-NC-ND 2012 Sara Riggare – http://twitter.com/SaraRiggare CC BY-NC-ND
  10. 10. 2012 Sara Riggare – http://twitter.com/SaraRiggare CC BY-NC-ND
  11. 11. 2012 Sara Riggare – http://twitter.com/SaraRiggare CC BY-NC-ND
  12. 12. 2012 Sara Riggare – http://twitter.com/SaraRiggare CC BY-NC-ND
  13. 13. 2012 Sara Riggare – http://twitter.com/SaraRiggare 2012 Sara Riggare – http://twitter.com/SaraRiggare CC BY-NC-ND CC BY-NC-ND
  14. 14. When crowdfunding meets quantified-self Clinical trials that patients consider important, at fractions of the cost
  15. 15. Crowdfunding clinical trials  Using un-expensive material to monitor patient and control groups  Opening the scope of hypotheses to be quickly tested  Exercise, dietary regimens  Existence of sub-types for the disease  Big Data coming to medical research  23AndMe gathered genetic material from 6500+ people with Parkinson’s, leading to new correlations between certain genes and the disease  We could create a database of daily-living measures for symptoms and impact of drugs (are there compounds slowing down progression?) 2012 FundMyMedicalResearch.org – http://twitter.com/FundMyMR CC BY-NC-ND
  16. 16. If you’re interested in a crowdfunding challenge for quantified-self trials Let’s emulate #SciFund Challenge success. If you’re interested in seeing a similar Challenge for #quantifiedself #medicaltrials:  Show this presentation around  Contact me at fbaud@p2pventure.org 2012 FundMyMedicalResearch.org – http://twitter.com/FundMyMR CC BY-NC-ND

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