This document summarizes a study comparing CD8+ T cell responses targeting the KK10 epitope of HIV-1 Gag protein in elite controllers and progressors expressing HLA-B*2705. The study found:
1) Controllers and progressors had similar frequencies and antigen sensitivity of KK10-specific CD8+ T cells, despite large differences in viral load.
2) KK10-specific CD8+ T cells in controllers and progressors differed in their polyfunctional profiles, with some subsets being more frequent in one group versus the other.
3) KK10-specific CD8+ T cells in controllers and progressors showed considerable diversity in T cell receptor usage,