PILOT PLANT SCALE-UP TECHNIQUE. BY MONA. introduction, lab. scale-up, stages of producing tablets, instrumantation, types, complication, and basic things about it.

1. Pilot-plant Scale-up
Consideration Of Solids
NAME – MONALISA NAYAK
CLASS –B.PHARM 7TH SEM
REGD NO – 1803268050
SUBJECT – INDUSTRIAL PHARMACY
COLLEGE– JEYPORE COLLEGE OF PHARMACY
1

2. Introduction
 Plant :- It is a place were the 5M’s like Money, Material,Man,
Method and Machine are brought together for manufacturing
of the product.
 Pilot-plant :- It is defined as a part of pharmaceutical Industry
where a free comercial production system which include new
production Technology.
 Scale-up :- “The art of designing of protype using the data
obtained from the pilot plant material.
2

3. Laboratory scale-up
 Once a formulation scientist develop a laboratory
scale product . The first step towards
commercialization is to scale it up at a pilot plant
level .
 Purpose of this Scale-up is to assure that the data ,
information and finding observed for small scale
batches are reproducible during comparatively
larger pilot scale manufacturing.
3

4. Stages of production Tablet
1. Material handling
2. Dry blending
3. Granulation
4. Drying
5. Reduction of particle size
6. Slugging
7. Compression
4

5. 1. Material handling :- In the laboratory , material are simply poured by
hand,but in large scale operation , handling of this material often
become necessary.
2. Dry blending :- Powdered to be used for encapsulation are to be
granulated and must be well blended to ensure good drug distribution.
 Miling of the Ingredients usually makes the process more reliable and
reproducible.
 Equipment required for blending :- V-blender,Double cone blender
5

6. V-blender
Double-Cone blender 6

7. 3. Granulation :- In this process in which the primary powder particles are made to
adhere to form large, multiparticle entities called granules.
Granulation process is a form of particle designing.
Types Of Granulation
 Wet Granulation Method - Tray dryer
 Dry Granulation Method – Slugging mill
7

8. 4.Drying :- Most common conventional method of drying a granulation
Continuous to be the circulating hot air oven ,which is heated by
either steam or electricity.
 Drying time at specified temperature and air flow rates must be established for each
product ,and for each particular oven load .
5. Reduction of particle size :- Compression factors that may be affected by
the particle size distribution are flow ability, compressibility,uniformity of the
tablet weight, tablet hardness and colour uniformity.
 Equipment:- Oscillating granulator, Screening device
8

9. 9
Oscilating Granulator
Screening Device

10. 6. Slugging :- The process is utilised to produce granules for moisture and
and heat –sensitive API and when APIS exhibit sufficient binding.
 The method of slugging is also known as dry Granulation.
10
Roll Compactor

11. 7. Compression :- The ultimate test of a tablet formulation and granulation
Process is weather the granulation can be compressed on
a high-speed tablet press .
Steps involved during compressed on a high-speed tablet press.
 Filling of empty die cavity with granulation
 Press compression of granulation
 Compress of granulation
11

13. 12