Nuclear receptors as target of new drug therapy
•Download as PPT, PDF•
24 likes•10,313 views
![[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]](data:image/gif;base64,R0lGODlhAQABAIAAAAAAAP///yH5BAEAAAAALAAAAAABAAEAAAIBRAA7)
Recommended
More Related Content
What's hot
What's hot (20)
Viewers also liked
Viewers also liked (20)
Similar to Nuclear receptors as target of new drug therapy
Similar to Nuclear receptors as target of new drug therapy (20)
Recently uploaded
Recently uploaded (20)
Nuclear receptors as target of new drug therapy
- 1. NUCLEAR RECEPTORS FOR DEVELOPING NEW DRUG THERAPY By MD. HABIBUR RAHMAN, M.Pharm. Asst. Professor, Dept. of Pharmacology. Anurag Pharmacy College, Kodad, Nalgonda (Dt), A. P
- 6. How does Cell surface Receptor elicits its action: Cell Membrane Unbound Endogenous Activator (Agonist) of Receptor Inactive Cell Surface Receptor Extracellular Compartment Intracellular Compartment N.B : Receptors are Present in equilibrium state of active and inactive conformation. Agonists binds with the active conformations.
- 7. Extracellular Compartment Intracellular Compartment Cell Membrane Bound Endogenous Activator (Agonist) of Receptor Active Cell Surface Receptor Cellular Response
- 8. Cell Membrane Displaced Endogenous Activator (Agonist) of Receptor Inactive Cell Surface Receptor Extracellular Compartment Intracellular Compartment Bound Antagonist of Receptor (Drug) N.B: Antagonist binds to the inactive conformations of the receptor.
- 9. How does Enzyme Receptor elicit its action: Active Enzyme Substrate Product Cellular Function Inactive Enzyme Substrate Bound Enzyme Inhibitor (Drug)
- 11. How does Nuclear Receptor elicit its action: Intracellular Compartment Nucleus DNA Modulation of Transcription Active Nuclear Receptor Bound Endogenous Activator (Agonist) of Nuclear Receptor
- 13. Displaced Endogenous Activator (Agonist) of Nuclear Receptor Intracellular Compartment Nucleus DNA Bound Antagonist of Receptor (Drug) Inactive Nuclear Receptor In Cytosolic Compartment Inactive Nuclear Receptor In Nuclear Compartment
- 26. Gene transcription cartoon showing interactions of ligand/PPAR/RXR heterodimer with cofactors and basal transcription machinery(RNA Polymerase II).
- 40. Pathogenesis: Diet with high fat Bile acid ( Lithocholic acid) poorly reabsorbed A toxic metabolite in enterohepatic circulation High conc. In colon Induce DNA strand breakage, inhibit DNA repair enzyme Colon Cancer
- 41. Pharmacology of VDR in colon cancer Vit-D VDR LCA Catabolism of CYP3A, a target gene Increased detoxification of LCA and elimination Protection against colon cancer.