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April - June 2011




Containment
The Quarterly Newsletter of the Containment of Artemisinin-Tolerent Malaria Parasites in South-East Asia Project
Surveillance of Day-3 Falciparum Malaria
Positives in Real-Time
  Malaria Consortium, through
the Containment Project, is pilot-                                                       Location on Google Earth
ing a Day-3 positive alert system
in western Cambodia’s Ta Sanh
district, using mobile phone
and web-based technology to
facilitate response to malaria
in real-time. CONTAINMENT’s
Sonny Inbaraj reports.
   EFFECTIVE      containment   of
multi-drug resistant falciparum
malaria depends on timely acquisi-
tion of information on new cases,
their location and frequency. This
is to plan interventions and focus
attention on speci c locations to
                                                                                                               Source: WHO/Sonny Krishnan
prevent an upsurge in transmis-
sion.                                  Diagram showing how a text message from the Ta Sanh Health Centre gets disseminated with
                                       FrontlineSMS.
   Response in western Cambodia’s
Ta Sanh district involves combining    skills of VMWs in other villages                   “Immediately after a villager tests
the process of positive diagnoses      in the Containment Project. The                  positive for falciparum malaria in a
through microscopy of Day 3 posi-      VMWs were also trained to carry                  rapid diagnostic test (RDT), I pre-
tives at the Ta Sanh health centre     out a three-day directly observed                pare the blood slides. Then I give
from blood slides sent by Village      treatment (DOT) of Pf cases with                 the drugs, which the villager has to
Malaria Workers, to an alert system    the co-formulated ACT dihydroar-                 take in front of me,” says Khea.
using mobile phone and web-based       temisinin - piperaquine.
technology to help pinpoint poten-                                                        “On Day 2 and Day 3, I’ll go to
tial outbreaks of malaria and target     Chou Khea, a 21-year-old Village               the villager’s house and make sure
interventions to foci where parasite   Malaria Worker, trained by MCC in                that the drugs are again taken in
reservoirs are likely to be present.   Ta Sanh district’s remote Ou Non-                my presence,” she adds. “After 72
                                       oung village tells CONTAINMENT                   hours from the rst intake of the
   The proportion of patients who      how she carries out DOT.                         anti-malaria drugs, I’ll be at the
still carry malaria parasites on the
third day of treatment is currently
the best measure available of slow
parasite clearance and can be used
as a warning system for con rma-
tion of artemisinin resistance.

   In Ta Sanh, the Village Malaria
Workers or VMWs play a crucial
role in the early detection and
treatment of the killer falciparum
malaria. In September 2010, the
Containment Project partnered the
USAID-funded University Research
Co., LLC (URC) to train these VMWs
to prepare blood slides on Days
Zero and 3, from those who tested
positive for falciparum malaria. A
similar partnership was entered
into with the public health and
development NGO Family Health                                                                                            Photo: WHO/MERG
International (FHI) to upgrade the     A validation of the SMS sent from the Ta Sanh Health Centre, from the database.


4      Containment       April - June 2011
“FrontlineSMS interfaces with
                                                                                                       an MS Access database system
                                                                                                       that was developed to host the
                                                                                                       SMS data and to provide validation
                                                                                                       on the data received and to send an
                                                                                                       automatic reply to the sender con-
                                                                                                       taining any validation errors found,
                                                                                                       or to con rm that the data has been
                                                                                                       accepted,” he adds.

                                                                                                          In the Access database, a script
                                                                                                       interfaces with Google Earth and
                                                                                                       maps out the locations of the Day 3
                                                                                                       positives based on the village code.
                                                                                                       The mapping on Google Earth is
                                                                                                       essential as it gives a clear visu-
                                                                                                       alisation of the terrain and helps
                                                                                                       CNM, WHO and the USAID-funded
                                                                                                       Cambodia Malaria Prevention and
                                                                           Photo: Malaria Consortium   Control Project (MCC) to plan coor-
Day 3 positives, in the Access database, mapped in real-time on Google Earth.                          dinated interventions in terms of
                                                                                                       case follow-up on Day Zero and Day
                                                                                                       3 and carry out epidemiological and
villager’s house again to take his               immediately sends out an SMS on                       entomological investigations.
or her blood sample for preparing                a mobile phone, using a dedicated
another blood slide.”                            number, to a database indicating                          “All this happens in real-time
                                                 the village code and the sex of the                   and alert text messages are sent
   Chou Khea then takes the Day                  patient.                                              out simultaneously to the opera-
Zero and Day 3 slides, together                                                                        tional district malaria supervisor,
with the used RDT, to the Ta Sanh                   Malaria Consortium pioneered                       the provincial health department,
Health Centre 30-kilometres away                 the use of this alert system in Ta                    CNM and the administrators of the
from her village.                                Sanh, with support from Cambodia’s                    database,” Mellor points out.
                                                 National Centre for Parasitology,
   “I usually take a motor-dop                   Entomology and Malaria Control                           There are plans to upscale this
(motorcycle taxi) to the health                  (CNM) and the World Health Organ-                     mobile phone and web-based alert
centre. But most of the motor-dop                ization’s Malaria Containment                         system with InSTEDD, an innova-
drivers are reluctant to use the track           Project funded by the Bill & Melinda                  tive humanitarian technology NGO,
to health centre in the rainy season             Gates Foundation.                                     to map all Day Zero cases. Malaria
because of the slippery mud. Also                                                                      Consortium and CNM are also in
many of them                                                                M a l a r i a              direct talks with Mobitel, one of
are scared of
the wild animals
                          There are plans to up-                         C o n s o r t i u m ’s
                                                                         Information Sys-
                                                                                                       Cambodia’s main telecommunica-
                                                                                                       tion carriers.
and land-mines           scale this mobile phone                         tems Manager
in the area,” she                                                        Steve          Mellor            “We are in negotiations with
tells CONTAIN-             and web-based alert                           explains the use              Mobitel for a free number and also
MENT         with                 system                                 of cellular text              free SIM cards to be distributed
concern. “I hope                                                         messaging (SMS)               to health centre staff and village
to have my own             with InSTEDD, an in-                          as a viable tool to           malaria workers,” Mellor reveals.
motorcycle soon,
so that I’ll be
                          novative humanitarian                          send alerts and
                                                                         map Day 3 posi-
                                                                                                       “After all, this is for a public
                                                                                                       good.”
able to transport          technology NGO, to                            tives in real-time
the slides and                                                           on Google Earth.                 Besides plans to map all Day Zero
RDTs      faster,”           map all Day Zero                                                          cases, Malaria Consortium is also
she adds with a                   cases…                           “We         use                     exploring the possibility of sending
smile.                                                           FrontlineSMS,                         alert messages in Khmer script.
                                                                 an open-source
  At the Ta Sanh Health Centre,                  software, that enables users to                         “This will be a breakthrough and
the Day 3 slides are examined by a               send and receive text messages                        we hope this will help facilitate a
microscopist and if asexual malaria              with groups of people through                         quick response mechanism from
parasites are seen they are graded               mobile phones,” Mellor tells CON-                     CNM and other partners,” says
as positive. The microscopist                    TAINMENT.                                             Mellor.


                                                                                               April - June 2011      Containment        5

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Surveillance of Day 3 Falciparum Malaria Positives in Real Time

  • 1. April - June 2011 Containment The Quarterly Newsletter of the Containment of Artemisinin-Tolerent Malaria Parasites in South-East Asia Project
  • 2. Surveillance of Day-3 Falciparum Malaria Positives in Real-Time Malaria Consortium, through the Containment Project, is pilot- Location on Google Earth ing a Day-3 positive alert system in western Cambodia’s Ta Sanh district, using mobile phone and web-based technology to facilitate response to malaria in real-time. CONTAINMENT’s Sonny Inbaraj reports. EFFECTIVE containment of multi-drug resistant falciparum malaria depends on timely acquisi- tion of information on new cases, their location and frequency. This is to plan interventions and focus attention on speci c locations to Source: WHO/Sonny Krishnan prevent an upsurge in transmis- sion. Diagram showing how a text message from the Ta Sanh Health Centre gets disseminated with FrontlineSMS. Response in western Cambodia’s Ta Sanh district involves combining skills of VMWs in other villages “Immediately after a villager tests the process of positive diagnoses in the Containment Project. The positive for falciparum malaria in a through microscopy of Day 3 posi- VMWs were also trained to carry rapid diagnostic test (RDT), I pre- tives at the Ta Sanh health centre out a three-day directly observed pare the blood slides. Then I give from blood slides sent by Village treatment (DOT) of Pf cases with the drugs, which the villager has to Malaria Workers, to an alert system the co-formulated ACT dihydroar- take in front of me,” says Khea. using mobile phone and web-based temisinin - piperaquine. technology to help pinpoint poten- “On Day 2 and Day 3, I’ll go to tial outbreaks of malaria and target Chou Khea, a 21-year-old Village the villager’s house and make sure interventions to foci where parasite Malaria Worker, trained by MCC in that the drugs are again taken in reservoirs are likely to be present. Ta Sanh district’s remote Ou Non- my presence,” she adds. “After 72 oung village tells CONTAINMENT hours from the rst intake of the The proportion of patients who how she carries out DOT. anti-malaria drugs, I’ll be at the still carry malaria parasites on the third day of treatment is currently the best measure available of slow parasite clearance and can be used as a warning system for con rma- tion of artemisinin resistance. In Ta Sanh, the Village Malaria Workers or VMWs play a crucial role in the early detection and treatment of the killer falciparum malaria. In September 2010, the Containment Project partnered the USAID-funded University Research Co., LLC (URC) to train these VMWs to prepare blood slides on Days Zero and 3, from those who tested positive for falciparum malaria. A similar partnership was entered into with the public health and development NGO Family Health Photo: WHO/MERG International (FHI) to upgrade the A validation of the SMS sent from the Ta Sanh Health Centre, from the database. 4 Containment April - June 2011
  • 3. “FrontlineSMS interfaces with an MS Access database system that was developed to host the SMS data and to provide validation on the data received and to send an automatic reply to the sender con- taining any validation errors found, or to con rm that the data has been accepted,” he adds. In the Access database, a script interfaces with Google Earth and maps out the locations of the Day 3 positives based on the village code. The mapping on Google Earth is essential as it gives a clear visu- alisation of the terrain and helps CNM, WHO and the USAID-funded Cambodia Malaria Prevention and Photo: Malaria Consortium Control Project (MCC) to plan coor- Day 3 positives, in the Access database, mapped in real-time on Google Earth. dinated interventions in terms of case follow-up on Day Zero and Day 3 and carry out epidemiological and villager’s house again to take his immediately sends out an SMS on entomological investigations. or her blood sample for preparing a mobile phone, using a dedicated another blood slide.” number, to a database indicating “All this happens in real-time the village code and the sex of the and alert text messages are sent Chou Khea then takes the Day patient. out simultaneously to the opera- Zero and Day 3 slides, together tional district malaria supervisor, with the used RDT, to the Ta Sanh Malaria Consortium pioneered the provincial health department, Health Centre 30-kilometres away the use of this alert system in Ta CNM and the administrators of the from her village. Sanh, with support from Cambodia’s database,” Mellor points out. National Centre for Parasitology, “I usually take a motor-dop Entomology and Malaria Control There are plans to upscale this (motorcycle taxi) to the health (CNM) and the World Health Organ- mobile phone and web-based alert centre. But most of the motor-dop ization’s Malaria Containment system with InSTEDD, an innova- drivers are reluctant to use the track Project funded by the Bill & Melinda tive humanitarian technology NGO, to health centre in the rainy season Gates Foundation. to map all Day Zero cases. Malaria because of the slippery mud. Also Consortium and CNM are also in many of them M a l a r i a direct talks with Mobitel, one of are scared of the wild animals There are plans to up- C o n s o r t i u m ’s Information Sys- Cambodia’s main telecommunica- tion carriers. and land-mines scale this mobile phone tems Manager in the area,” she Steve Mellor “We are in negotiations with tells CONTAIN- and web-based alert explains the use Mobitel for a free number and also MENT with system of cellular text free SIM cards to be distributed concern. “I hope messaging (SMS) to health centre staff and village to have my own with InSTEDD, an in- as a viable tool to malaria workers,” Mellor reveals. motorcycle soon, so that I’ll be novative humanitarian send alerts and map Day 3 posi- “After all, this is for a public good.” able to transport technology NGO, to tives in real-time the slides and on Google Earth. Besides plans to map all Day Zero RDTs faster,” map all Day Zero cases, Malaria Consortium is also she adds with a cases… “We use exploring the possibility of sending smile. FrontlineSMS, alert messages in Khmer script. an open-source At the Ta Sanh Health Centre, software, that enables users to “This will be a breakthrough and the Day 3 slides are examined by a send and receive text messages we hope this will help facilitate a microscopist and if asexual malaria with groups of people through quick response mechanism from parasites are seen they are graded mobile phones,” Mellor tells CON- CNM and other partners,” says as positive. The microscopist TAINMENT. Mellor. April - June 2011 Containment 5