Occupational epidemiology and exposure assessment
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A lecture given at the University of Cambridge MPhil course in Public Health
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Occupational epidemiology and exposure assessment
- 1. Occupational Epidemiology and Exposure Estimation John Cherrie www.OH-world.org
- 5. Asbestos lung cancer epidemiology…
- 9. Changes…
- 14. From source to dose ambient concentration exposure internal exposure source dose disease
- 25. Structured subjective assessment Where... i = intrinsic emission h = handling lv = local controls etc.
- 26. Exposure estimation... Change in technology Ventilation introduced
- 27. Validity... 10 1 0.1 0.01 0.001 0.001 0.01 0.1 1 10
- 31. A serious public health risk...
- 33. Mesothelioma risk for a child... Age 10, exposed to 1fibre/ml for one day
- 34. So what should we do?
- 36. What are your conclusions?
- 38. Check out www.OH-world.org
Editor's Notes
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- 02/24/10 Studies published between 1974 and 1998
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- 02/24/10 First follow-up to 1979 produced small non-significant excesses of lung cancer. Increases in risk with time since first exposure. Studies continued with follow-up to early 1980s Only 2 mesothelioma deaths
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- 02/24/10 133 cases, 513 controls No consistent risk for asbestos or silica, although exposures quite low. Risk for current smokers (>400kg) vs non or low smokers was OR=10 (people employed >1yr)
- 02/24/10 Armstrong BK, White E, Saracci R. (1990) Principles of exposure measurement in epidemiology. Monographs on Epidemiology and Biostatistics 21. Oxford: Oxford University Press.
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- 02/24/10 Cherrie JW and Aitken R. (in press) Measurement of human exposure to biologically relevant fractions of inhaled aerosols . Occupational and Environmental Medicine.
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- 113 men who worked in an asbestos factory. 02/24/10
- Nested case-control study. Cohort 31k men – data from pension fund. Job information only. OR for engine crew for mesothelioma was 9.75, 20 year latency 02/24/10
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- 02/24/10 Cherrie JW. (in press) The effect of room size and general ventilation on the relationship between near and far-field concentrations. Applied Environmental and Occupational Hygiene. Cherrie JW, Schneider T. (in press) Validation of a new method for structured subjective assessment of past concentrations. Ann.occup.Hyg. Seaton A, Cherrie JW. (1998) Quartz exposures, hilar lymphadenopathy and severe silicosis. Occup Env.Med.; 55: 383-386.
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- 02/24/10 Watt M, Godden D, Cherrie J, Seaton A. (1995). Individual exposure to particulate air pollution and its relevance to thresholds for health effects: a study of traffic wardens. Occupational and Environmental Medicine; 52: 790 ‑ 792.
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