2. INTRODUCTION :
• Fidelity of DNA replication is depend on the
enzyme to catalyze many reaction before
relasing its substrate is called processivity.
• The key of processivity of DNA polymerase tjat
act at the replication fork in their association
with protein called sliding DNA clamps.
3. • The speed of DNA synthesis is largely due to
the progressive nature of DNA polymerase III
due to its binds with sliding DNA clamps and
stabilizes itself in elongation process.
• Thus the replication fidelity increases.
4.
5. • The another reason for fidelity is the proof
reading process of replication.
• In proof reading process, the incorrect base
pairs remove by the nucleus that originally
identified in the same polypeptide as the DNA
polymerase.
• In the polymerase 1 two nuclease , one is
exonuclease and one is endonuclease .
• Thus the fidelity is increased of the DNA
replication .
6. CONCLUSION :
• DNA replication itself can occasionally
damage, called mutation that introduces error,
hence the maintainance of the DNA
replication is needed for the next generation
purpose.
• DNA molecules are themselves irreplaceable,
it can cause cellular damage too.
7. • Fidelity of DNA replication depends on the
proof reading, repair system as well as in
some enzymes function.
• Such mechanism of DNA replication fidelity is
also depends on the onway repair system like
nick translation done by the phosphodiester
bonds and with the help of ATPs.