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MADE BY: LALIT SINGH
STUDENT OF M-PHARM
(PHARMACEUTICALANALYSIS)
ISF COLLEGE OF PHARMACY,
MOGA
1
CONTENT
 Introduction
 Classification
 Alpha Particle
 Beta Particle
 Gamma Rays
 Biological effect of radiation
2
INTRODUCTION
Radiopharmacetical :- These are the compound and
substance which emit radiation and which are used in
medicine are called Radiopharmacetical.
Radio isotopes, radioactive isotope , radio nucleus and
isotope are used generally for substance which emit
ionizing radiation.
3
 All the substance made of atom.
 Isotope :- the atom have the same number of
proton but different number of nutron.
4
-
++
-
-
+
-
-
-
-
Type of radioactivity
Natural Radioactivity Artificial Radioactivity
5
S.No. Characteristic Alpha Beta Gamma
1 Nature It have 2 proton and 2
neutron
It is same like a
electron
It is an electromagnetic wave
2 Charge +2 -1 0
3 Mass Relatively Large Very small No Mass
4 Speed Slow Fast Speed of light
5 Ionizing Strong Weak Very weak
6 Most dengerous When source is inside the
body
When source is
Outside the body
When source is outside the
body
6
ALPHA PARTICLE
 Alpha particle made up of 2 proton and 2 neutron.
 We can write them because they are the same as a
helium nucleus.
 When a nucleus emit an alpha particle its atomic number
decrease by 2 and its atomic mass decrease by 4.
 Alpha particle are relatively slow and heavy.
 They have a low penetrating power.
7
CONT…
 You can stop them with just a sheet of
paper
:- because they have a large charge alpha
particle ionize other atom strongly.
 Alpha decay occurs in very heavy element
e.g :- Radium and uranium
8
BETA PARTICLE
 Beta particle have a charge of -1.
 the means that beta particle are the same as an
electron.
 We can write them as because they are the same
as electron
 This means that when a nucleus emit a beta particle
:-
The atomic mass unchanged.
The atomic number increase by 1.
9
CONT..
 They are fast and light.
 Beta particle have a medium penitrating
power.
 They are stopped by a sheet of
alumminium e.g :- phosphorus 32.
10
GAMMA RAYS
 Gamma rays are waves not particle.
 This means that they have no mass and no
charge.
 In gamma decay:-
Atomic number unchanged
Atomic mass unchanged
Gamma ray have a high penetrating power.
11
CONT..
 It take a thick sheet of metal such as lead to
reduce them.
 Gamma rays do not directly ionize other
atoms
 We do not find pure gamma source. Gamma
ray are emitted along with alpha and beta
particle.
12
BIOLOGICAL EFFECT OF RADIATION
 Radiation have dangerous effect on biological system.
 Locally induced ionization promotes a number of irreversible
change in living cell.
 These change can be noticed after a short period of time or
may take year to develop.
 As in case of genetic change the effect can be seen in
subsequent generation.
 It must be assumed that all effect of radiation on living cell are
harmful.
 There is no threshold level for the onset of there effect.
13
CONT..
Radiation
Intraction with molecle
Present in tissue
Tissue produce
Abnormal amount of ion or free radical
14
Chemical entity
Aulter/ change
Local pH
Initiate
Ion/ free radical
Formation
Peroxide, other toxic species
Cell death
15
16

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Radiopharmacetical

  • 1. MADE BY: LALIT SINGH STUDENT OF M-PHARM (PHARMACEUTICALANALYSIS) ISF COLLEGE OF PHARMACY, MOGA 1
  • 2. CONTENT  Introduction  Classification  Alpha Particle  Beta Particle  Gamma Rays  Biological effect of radiation 2
  • 3. INTRODUCTION Radiopharmacetical :- These are the compound and substance which emit radiation and which are used in medicine are called Radiopharmacetical. Radio isotopes, radioactive isotope , radio nucleus and isotope are used generally for substance which emit ionizing radiation. 3
  • 4.  All the substance made of atom.  Isotope :- the atom have the same number of proton but different number of nutron. 4 - ++ - - + - - - -
  • 5. Type of radioactivity Natural Radioactivity Artificial Radioactivity 5
  • 6. S.No. Characteristic Alpha Beta Gamma 1 Nature It have 2 proton and 2 neutron It is same like a electron It is an electromagnetic wave 2 Charge +2 -1 0 3 Mass Relatively Large Very small No Mass 4 Speed Slow Fast Speed of light 5 Ionizing Strong Weak Very weak 6 Most dengerous When source is inside the body When source is Outside the body When source is outside the body 6
  • 7. ALPHA PARTICLE  Alpha particle made up of 2 proton and 2 neutron.  We can write them because they are the same as a helium nucleus.  When a nucleus emit an alpha particle its atomic number decrease by 2 and its atomic mass decrease by 4.  Alpha particle are relatively slow and heavy.  They have a low penetrating power. 7
  • 8. CONT…  You can stop them with just a sheet of paper :- because they have a large charge alpha particle ionize other atom strongly.  Alpha decay occurs in very heavy element e.g :- Radium and uranium 8
  • 9. BETA PARTICLE  Beta particle have a charge of -1.  the means that beta particle are the same as an electron.  We can write them as because they are the same as electron  This means that when a nucleus emit a beta particle :- The atomic mass unchanged. The atomic number increase by 1. 9
  • 10. CONT..  They are fast and light.  Beta particle have a medium penitrating power.  They are stopped by a sheet of alumminium e.g :- phosphorus 32. 10
  • 11. GAMMA RAYS  Gamma rays are waves not particle.  This means that they have no mass and no charge.  In gamma decay:- Atomic number unchanged Atomic mass unchanged Gamma ray have a high penetrating power. 11
  • 12. CONT..  It take a thick sheet of metal such as lead to reduce them.  Gamma rays do not directly ionize other atoms  We do not find pure gamma source. Gamma ray are emitted along with alpha and beta particle. 12
  • 13. BIOLOGICAL EFFECT OF RADIATION  Radiation have dangerous effect on biological system.  Locally induced ionization promotes a number of irreversible change in living cell.  These change can be noticed after a short period of time or may take year to develop.  As in case of genetic change the effect can be seen in subsequent generation.  It must be assumed that all effect of radiation on living cell are harmful.  There is no threshold level for the onset of there effect. 13
  • 14. CONT.. Radiation Intraction with molecle Present in tissue Tissue produce Abnormal amount of ion or free radical 14
  • 15. Chemical entity Aulter/ change Local pH Initiate Ion/ free radical Formation Peroxide, other toxic species Cell death 15
  • 16. 16