Cell com lecture_1-2_pharmacology_2010

Cellular Communication & Introduction to Drug Action (MEDI 1203) Introduction to Pharmacology Musbah Tanira Department of Pharmacology and Clinical Pharmacy

Pharmacology Component ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

Objectives ,[object Object],[object Object],[object Object],[object Object]

What is a drug? ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

Where the drugs come from? ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

What is Pharmacology? ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

Drug discovery ,[object Object],[object Object],[object Object]

Terminology in Pharmacology ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

Terminology in Pharmacology ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

Terminology in Pharmacology ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

Drug Discovery ,[object Object],[object Object],[object Object],[object Object]

Drug Names and Classification ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

Drug Names and Classification ,[object Object],[object Object],[object Object],[object Object],[object Object]

How drugs are given? ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

ROUTES OF ADMINISTRATION ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

Cellular Communication & Introduction to Drug Action (MEDI 1203) How Do Drugs Get Absorbed Musbah Tanira Department of Pharmacology and Clinical Pharmacy

Objectives ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

Pharmacokinetics ,[object Object],[object Object],[object Object]

Pharmacokinetics ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

Absorption ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

Absorption ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

Membrane properties ,[object Object],[object Object],[object Object],[object Object],non-polar tail phospholipid { polar head

Membrane properties Transmembrane protein Hydrophilic head Hydrophobic tail

Membrane properties ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

pH effect ,[object Object],[object Object],[object Object],[object Object]

pH effect ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

Absorption ,[object Object],[object Object],[object Object],[object Object],[object Object],Comparison Stomach Small intestine pH 1.5 - 4 6.7 - 8 Surface area (m 2 ) ~1 ~200 Blood flow (mL/min) 150 1000

Bioavailability ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

Bioavailability ,[object Object]

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