Pathogenesis41

GENERAL ASPECTS OF BACTERIAL PATHOGENESIS Faculty: Dr. Alvin Fox

Key Words Pathogen Transmission Outbreak, Epidemic, Pandemic Adhesion Normal flora Penetration Infection Invasiveness/spread Infectious diseases Extra/intra cellular pathogen Compromised host Exotoxin Opportunistic infection Endotoxin - non-specific immunity Nosocomial Specific immunity Koch’s postulates Autoimmunity Bioterrorism

Pathogenicity ,[object Object],[object Object],[object Object]

Pathogens ,[object Object],[object Object],[object Object],[object Object],[object Object]

Koch's postulates ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

Opportunistic infections ,[object Object],[object Object],[object Object]

Opportunists - normal flora ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

Opportunists - environment ,[object Object],[object Object],[object Object],[object Object]

Opportunists in hospital ,[object Object]

Transmission ,[object Object],[object Object],[object Object],[object Object]

Host defenses ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

Adhesion adhesin EPITHELIUM receptor BACTERIUM

S. pyogenes fibronectin F-protein lipoteichoic acid

E. coli fimbriae mannose Type 1 ,[object Object],[object Object],[object Object],P

Penetration and spread Vibrio cholerae Salmonella enteritidis Salmonella typhi Epithelium Gut lumen Blood stream

Connective tissue destrction ,[object Object],[object Object],[object Object]

Extracellular pathogens ,[object Object],[object Object],[object Object],[object Object]

Protein A inhibits phagocytosis Protein A immunoglobulin Fc receptor BACTERIUM PHAGOCYTE

M protein inhibits phagocytosis M protein peptidoglycan Complement fibrinogen r r r

Intracellular parasite No fusion Lysozome Phagosome Fusion Enter cytoplasm Bacteria Macrophage or neutrophil

Killing of intracellular parasite ,[object Object]

Tissue Injury ,[object Object],[object Object],[object Object],[object Object],[object Object]

Exotoxins ,[object Object],[object Object],[object Object],[object Object]

A-B toxins Active Binding A Cell surface B

[object Object],[object Object],[object Object],[object Object]

Cholera toxin and E. coli labile toxin ,[object Object],[object Object],[object Object],[object Object],[object Object]

[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

[object Object],[object Object],[object Object],[object Object],Exotoxins - extracellular matrix of connective tissue

[object Object],[object Object],[object Object],Membrane damaging exotoxins

[object Object],[object Object],[object Object],[object Object],C. perfringens phospholipase

Exotoxins ,[object Object],[object Object]

Endotoxin ,[object Object],[object Object],[object Object],[object Object]

[object Object],[object Object],[object Object],[object Object],[object Object],Septic shock

Endotoxins ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

Specific immunity and immunopathology ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

[object Object],[object Object],[object Object],[object Object],[object Object],IgA proteases

Bioterrorism ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

Pathogenesis41

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Pathogenesis41