Hiv Vaccines Overview

HIV Vaccines Overview Shaleena Theophilus

Definitions ,[object Object],[object Object],[object Object],[object Object]

[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

Vaccine Type Disease Live, attenuated vaccine Measles, mumps, rubella, polio (Sabin vaccine), yellow fever Inactivated or “killed” vaccine Cholera, flu, hepatitis A, Japanese encephalitis, plague, polio (Salk vaccine), rabies Toxoid vaccine Diphtheria, tetanus Subunit vaccines Hepatitis B, pertussis, pneumonia caused by Streptococcus pneumoniae Conjugate vaccines Haemophilus Influenza type B, pneumonia caused by Streptococcus pneumoniae DNA vaccines In clinical testing Recombinant vector vaccines In clinical testing

HIV/AIDS Vaccine Mechanisms HIV VACCINE Treatment Prevent Infection Lower Initial Peak Viremia Lower Set Point or Eliminate HIV Stop Progression

[object Object],[object Object]

[object Object],Beyond HIV 101

www.dkfz.de/de/f020/groups/bosch/index.html

Prime Boost Strategy Immune Response Prime Boost

HIV Genes Code Vaccine Targets ,[object Object],[object Object],[object Object],[object Object],[object Object]

HIV Vaccine Strategies ,[object Object],[object Object],[object Object],[object Object],[object Object],Virus-like Particles / Pseudovirions +/- Adjuvants Combinations Whole killed HIV Live attenuated HIV X X (therapeutic history)

DNA Vaccines ,[object Object],[object Object]

[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],Viral Vector Vaccines Adenovirus

Step Study ,[object Object],[object Object]

HIV Vaccine Strategies ,[object Object],[object Object],[object Object],[object Object],[object Object],Virus-like Particles / Pseudovirions +/- Adjuvants Combinations Whole killed HIV Live attenuated HIV X X (therapeutic history) HIV Vaccine Strategies ,[object Object],[object Object],[object Object],[object Object],[object Object],Virus-like Particles / Pseudovirions +/- Adjuvants Combinations Whole killed HIV Live attenuated HIV X X (therapeutic history)

Dendritic Cell Vaccines ,[object Object],[object Object],[object Object],T Breinig, 2005

Dendritic Cell Vaccine in HIV-1 Infection ,[object Object],[object Object],[object Object]

Immune Response to a Therapeutic HIV Vaccine Followed by Treatment Interruption in Patients With Acute or Recent HIV Infection ,[object Object],www.Clinicaltrials.gov

Safety and Tolerability of and Immune Response to LC002, an Experimental Therapeutic Vaccine, in Adults Receiving Anti-HIV Treatment ,[object Object],www.Clinicaltrials.gov

Study of the HIV gp120/NefTat/AS02A Vaccine to Treat Individuals With Chronic HIV-1 Infection on Highly Active Antiretroviral Therapy (HAART) ,[object Object],www.Clinicaltrials.gov

Canadian Trials ,[object Object],[object Object],[object Object],[object Object],[object Object]

Canadian HIV Vaccines Plan http://pubs.cpha.ca/PDF/P36/23414e.pdf http://pubs.cpha.ca/PDF/P36/23414f.pdf

Canadian HIV Vaccines Initiative ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

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Global Vaccines Enterprise ,[object Object],[object Object],[object Object],[object Object]

[object Object],[object Object],[object Object],[object Object],Useful websites

Other useful websites ,[object Object],[object Object],[object Object]

Hiv Vaccines Overview

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