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Liver Disease

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Miami Dade
Miami Dade
Health & Medicine
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[object Object],Diseases of the Liver & Biliary System
Liver regeneration ,[object Object],[object Object],[object Object],[object Object]
 
 
NORMAL CT SCAN
Liver blood supply ,[object Object],[object Object]
Functional anatomy ,[object Object],[object Object],[object Object]
Functional anatomy ,[object Object],[object Object],[object Object]
 
Hepatic Ducts ,[object Object],[object Object],[object Object],[object Object]
Gallbladder ,[object Object],[object Object],[object Object],[object Object],[object Object]
 
 
 
 
What Does the Liver Do? ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Role of Liver (cont) ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Role of the liver (cont) ,[object Object],[object Object],[object Object],[object Object]
Role of the liver (cont) ,[object Object],[object Object]
Liver Physiology ,[object Object],[object Object],[object Object]
Hepatic Physiology (cont.) ,[object Object],[object Object]
 
 
 
 
Disorders ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
 
 
 
 
 
History ,[object Object],[object Object]
Physical exam ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
Tests of liver function ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Tests of Liver Function ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
 
PT (prothrombin time) & INR (international normalized ratio) ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
 
 
 
LFT’s/Transaminases ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
AST/ALT ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
AST/ALT ,[object Object],[object Object],[object Object]
Serum Alkaline Phosphatase- (Alk Phos) ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Alk Phos
Alk Phos
Alk Phos
 
 
 
LFT’s/ Diagnostic Tests ,[object Object],[object Object],[object Object],[object Object]
Tests for biliary obstruction/cholestasis &/or hepatocellular damage ,[object Object],[object Object],[object Object],[object Object]
Approach to Jaundice ,[object Object],[object Object],[object Object],[object Object],[object Object]
Bilirubin Metabolism ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Bilirubin conjugation ,[object Object],[object Object],[object Object],[object Object],[object Object]
 
 
Bilirubin Metabolism ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Hyperbilirubinemia ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Unconjugated (Indirect) hyperbilirubinemia ,[object Object],[object Object],[object Object]
Unconjugated (Indirect) hyperbilirubinemia ,[object Object]
Unconjugated (Indirect) hyperbilirubinemia ,[object Object],[object Object],[object Object],[object Object],[object Object]
Conjugated (Direct) hyperbilirubinemia ,[object Object],[object Object],[object Object],[object Object],[object Object]
Conjugated (Direct) hyperbilirubinemia ,[object Object],[object Object],[object Object],[object Object]
Causes of Conjugated (Direct) hyperbilirubinemia ,[object Object],[object Object],[object Object]
[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],Diagnosis of conjugated hyperbilirubinemia
Disorders of the Biliary System ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Special diagnostic procedures in cholestatic jaundice ,[object Object],[object Object],[object Object]
Hyperbilirubin Mneumonic ,[object Object]
 
 
 
 
 
 
 
 
Hepatitis ,[object Object],[object Object]
Hepatitis Causes ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],**Hepatitis E & A are fecal-oral (f E c A l –oral) **While Hep B,C,D are blood borne (parenteral) “ C oming in the B ack D oor”
 
 
Acute Hepatitis ,[object Object],[object Object],[object Object],[object Object],[object Object]
Acute Hepatitis ,[object Object],[object Object],[object Object],[object Object]
Acute Hepatitis ,[object Object],[object Object],[object Object]
Symptoms of Hepatitis ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Clinical findings of Hepatitis ,[object Object],[object Object],[object Object],[object Object]
Laboratory Tests (LFT’s) ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Complications of Hepatitis ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Don’t complain about the seating arrangements
Mononucleosis Epstein-Barr Virus (EBV) ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Mononucleosis (EBV) ,[object Object],[object Object]
Mononucleosis (EBV) ,[object Object],[object Object],[object Object],[object Object],[object Object]
Mononucleosis Epstein-Barr virus ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Mononucleosis (EBV) ,[object Object],[object Object],[object Object],[object Object],[object Object]
Mononucleosis (EBV) ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Cytomegalic Virus ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Hepatitis A ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Hepatitis A (cont) ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Hepatitis A (cont) ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Hepatitis B ,[object Object],[object Object],[object Object]
Hepatitis B ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Hepatitis B (Lab continued) ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
 
 
Serologic Markers: ,[object Object],[object Object],[object Object],[object Object]
Serologic Markers: ,[object Object],[object Object]
Serologic Markers: (cont) ,[object Object]
Serologic Markers: (cont) ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Serologic Markers: (cont) ,[object Object],[object Object],[object Object],[object Object]
Serologic Markers: (cont) ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Immunization for HBV (with HBsAg) - - - + - Low-level HBsAg carrier or remote past infection +/- - IgG - - Recovery from HBV infection +/- - IgG + - Acute HBV infection (anti-HBc window) +/- +/- IgM - - Heterotypic anti-HBs with HBsAg; usually indicates chronic HBV carrier state +/- +/- + + + Late-acute or chronic HBV infection, low infectivity + - IgG - + Chronic HBV, high infectivity - + IgG - + Acute HBV, high infectivity - + IgM - + Interpretation Anti-HBe HBeAg Anti-HBc Anti-HBs HbsAg
Screening ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Hepatitis B ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Hepatitis B ,[object Object],[object Object],[object Object],[object Object]
 
Hepatitis C ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Hepatitis C ,[object Object],[object Object],[object Object],[object Object],[object Object]
Hepatitis C ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Hepatitis C treatment (cont) ,[object Object],[object Object],[object Object]
Hepatitis C ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
 
Hepatitis D ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Hepatitis E ,[object Object],[object Object],[object Object],[object Object],[object Object]
 
 
 
Alcoholic Hepatitis ,[object Object],[object Object],[object Object],[object Object],[object Object]
Alcoholic Hepatitis Symptoms ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Alcoholic Hepatitis Physical Findings ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Alcoholic Hepatitis Damage to liver causes ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Alcoholic Hepatitis Damage to the Portal System ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
 
Alcoholic Hepatitis Diagnostic Studies ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Alcoholic Hepatitis Diagnostic Studies ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
 
Acute Hepatitis Course ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Acute hepatitis course (cont.) ,[object Object],[object Object],[object Object],[object Object]
Acute hepatitis Therapy ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
 
Acute Hepatitis Therapy (cont) ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Acute Hepatitis Nutritional Complications: ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Drug Related Hepatitis ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Drug Related Hepatitis ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
 
[object Object]
Chronic Hepatitis ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
 
Chronic Hepatitis ,[object Object],[object Object],[object Object],[object Object],[object Object]
Chronic Hepatitis Autoimmune Hepatitis ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Chronic Hepatitis Autoimmune Hepatitis ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Other causes of Chronic Hepatitis ,[object Object],[object Object],[object Object],[object Object],[object Object]
Wilson’s Disease ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Wilson’s disease (cont) ,[object Object],[object Object],[object Object]
 
 
 
Haemochromatosis ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Alpha 1-Antitrypsin Deficiency ,[object Object],[object Object],[object Object],[object Object]
Reye’s Syndrome ,[object Object],[object Object],[object Object],[object Object],[object Object]
REYE'S SYNDROME ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
 
Hepatic (Liver) Failure ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
 
Hepatic Failure (cont) ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Liver failure (chronic): signs found on the arms Mneumonic ,[object Object]
 
Hepatic Failure (cont) ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Hepatic encephalopathy: precipitating factors Mneumonic ,[object Object]
 
Hepatic failure (cont) Hepatic Encephalopathy ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Cirrhosis ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Causes of hepatic cirrhosis Mneumonic ,[object Object]
Cirrhosis: differential: common and rarer · Mneumonic ,[object Object],[object Object]
Cirrhosis
 
 
Cirrhosis (cont) ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Cirrhosis (cont) ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Cirrhosis (cont) ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
 
 
 
Ascites (cont) ,[object Object],[object Object],[object Object],[object Object],[object Object]
Ascites
Ascites (cont) ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Ascites treatment (cont) ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Portal Hypertension ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
 
Portal Hypertension (cont) ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
 
 
 
 
 
Liver Review ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Liver Review ,[object Object],[object Object],[object Object],[object Object]
Liver review ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Liver Jeopardy Facts ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

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  • 129. Immunization for HBV (with HBsAg) - - - + - Low-level HBsAg carrier or remote past infection +/- - IgG - - Recovery from HBV infection +/- - IgG + - Acute HBV infection (anti-HBc window) +/- +/- IgM - - Heterotypic anti-HBs with HBsAg; usually indicates chronic HBV carrier state +/- +/- + + + Late-acute or chronic HBV infection, low infectivity + - IgG - + Chronic HBV, high infectivity - + IgG - + Acute HBV, high infectivity - + IgM - + Interpretation Anti-HBe HBeAg Anti-HBc Anti-HBs HbsAg
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