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人工智慧醫學診斷中心
AI Center for Medical Diagnosis
CUDA加速先進影像分析技術與深度學習
於臨床電腦斷層掃瞄肝細胞腫瘤輔助診斷
AI-assisted Diagnosis of Hepatocellular Carcinoma
using CUDA Radiomics and Deep Learning
林仰賢 游家鑫
• Background
– Hepatocellular Carcinoma
– Exams and Diagnosis
• Radiomics
– Acceleration
• Unmet Clinical Need
• Deep Learning in Hepatocellular Carcinoma
• Future Works
2
Agenda
GTC	Taiwan	2017
Hepatocellular Carcinoma (HCC)
• Background
• Material	and	Methods
– Optical	Setup
– Phase	Retrieval
• Results
• Conclusion • Radiographic	Imaging
– Ultrasound
– Computed	Tomography	(CT)
– Magnetic	Resonance	Imaging	(MRI)
– Angiography
GTC	Taiwan	2017
3
Hepatitis	B	Virus
Hepatitis	C	Virus
Alcohol
NASH
Aflatoxin
4
Dynamic CT
Non-enhanced	CT Late	Arterial	Phase Venous	PhaseEarly	Arterial	Phase
• Enhanced	Tumor
GTC	Taiwan	2017 IRB:	CMUH106-REC1-072
• Diagnostic	algorithm	for	suspected	HCC
5
Diagnostic Criteria
Liver Nodule
< 1cm > 1cm
Repeat US at 3 months
Growing/changing Character Stable
Investigate according to size
4-phase MDCT/dynamic contrast enhanced MRI
Arterial hypervascularity AND venous or
delayed phase washout
Other contrast enhanced study (CT or MRI)
Arterial hypervascularity AND venous or
delayed phase washout
Yes
HCC
No
No
Biopsy
Yes
GTC	Taiwan	2017
AASLD practice guideline (2017)
6
Gross Tumor Volume
Transverse	Plane Coronal	Plane Sagittal	Plane 3-D	Rendering
• Orthogonal	Views
GTC	Taiwan	2017
7
Radiomics
Image	Acquisition DiagnosisFeature	Extraction Neural	Network Prediction
GTC	Taiwan	2017
8
Acceleration on Radiomics
Feature	Extraction
GTC	Taiwan	2017
Volume	of	InterestMethodologies
Morphometrics
LoG Operation
Wavelet	Texture
Laws	Texture
Gray-level	Co-occurrence	Matrix
Gray-level	size	zone
……
• Extract	more	information
• Easy	parallelization	on	GPU
• Improve	diagnosis	accuracy
• Evaluate	disease progression
• Predict	patient	outcomes
• Data	sharing
9
Advantages of Radiomics
GTC	Taiwan	2017
CT	ImagesFeature	ExtractionRadiomics Heat	Map
10
Unmet Clinical Needs
GTC	Taiwan	2017
Recurrence
Metastasis	
Treatment
11
Process and Tools
GTC	Taiwan	2017
HCC
Diagnoses
Curative
Treatment
Follow-up
3	- 6	months
Follow-up
2	years
Medical	Images Blood	Tests
Tools
12
Radiomics and Machine Learning
GTC	Taiwan	2017
Medical Image Radiomics Features Classifier
Metastasis Accuracy: 94%(5-Fold)
13
Why we need deep learning
GTC	Taiwan	2017
HCC
Diagnoses
Follow-up
3	- 6	months
Curative
Treatment
20	Cases	
per	day
Less More
Miss	Rate 7% 15%
HCC
Recurrence
(within	2	years)
Metastasis
(within	5	years)
After	Curative	
Treatment 70% 90%
14
Scanning Protocol Difference
GTC	Taiwan	2017
15
Augmentation
GTC	Taiwan	2017
Scale
Translate Rotate Blur
Contrast Normalization
Origin
16
Deep Neural Network
GTC	Taiwan	2017
CONV3D
CONV3D
MaxPool3D
CONV3D
CONV3D
MaxPool3D
CONV3D
CONV3D
MaxPool3D
CONV3D
CONV3D
FC
CONV3D
CONV3D
MaxPool3D
CONV3D
CONV3D
MaxPool3D
CONV3D
CONV3D
MaxPool3D
CONV3D
CONV3D
FC
17
Deep Neural Network
GTC	Taiwan	2017
MLP
FC
18
NVIDIA DIGITS
GTC	Taiwan	2017
256*256 (2D)
GoogLeNet
19
Future works
GTC	Taiwan	2017
HCC
Diagnose
Curative
Treatment
Follow-up
3	- 6	months
Follow-up
2	years
Recurrence	
Risk	Assessment	
+
GTC	Taiwan	2017
Acknowledging
China	Medical	University
Tzung-Chi	Huang,	Ph.D.
China	Medical	University	Hospital
Wei-Ching Lin,	M.D.
Shih-Neng Yang,	M.D.
Chun-Chieh Yeh,	M.D.
NVIDIA
Andrew	Liu,	Ph.D.
Moffitt	Cancer	Center
Geoffrey	G	Zhang,	Ph.D.
China	Medical	University		Beigang Hospital
Tsung-Jung	Ho,	M.D.
Chang	Bing	Show	Chwan Memorial	Hospital
Kuan-Yung	Chen,	M.D.
Chih-Yen	Tu,	M.D.
Chia-Huang	Chen,	M.D.
Wei-Chih Liao,	M.D.
Thank you
GTC	Taiwan	2017

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GTC Taiwan 2017 自主駕駛車輛發展平台與技術研發
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GTC Taiwan 2017 自主駕駛車輛發展平台與技術研發
 
GTC Taiwan 2017 人工智慧:保險科技的未來
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GTC Taiwan 2017 從雲端到終端的瓶頸及解決之道
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GTC Taiwan 2017 如何在充滿未知的巨量數據時代中建構一個數據中心
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GTC Taiwan 2017 如何在充滿未知的巨量數據時代中建構一個數據中心
 
GTC Taiwan 2017 用計算來凝視複雜的世界
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GTC Taiwan 2017 在 Google Cloud 當中使用 GPU 進行效能最佳化
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GTC Taiwan 2017 NVIDIA VRWorks SDK 加速性能與提升 VR 使用經驗
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GTC Taiwan 2017 NVIDIA VRWorks SDK 加速性能與提升 VR 使用經驗
 
GTC Taiwan 2017 NVIDIA Holodeck 與 Isaac VR 技術分享
GTC Taiwan 2017 NVIDIA Holodeck 與 Isaac VR 技術分享GTC Taiwan 2017 NVIDIA Holodeck 與 Isaac VR 技術分享
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GTC Taiwan 2017 深度學習於表面瑕疵檢測之應用
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GTC Taiwan 2017 深度學習於表面瑕疵檢測之應用
 
GTC Taiwan 2017 結合智能視覺系統之機械手臂
GTC Taiwan 2017 結合智能視覺系統之機械手臂GTC Taiwan 2017 結合智能視覺系統之機械手臂
GTC Taiwan 2017 結合智能視覺系統之機械手臂
 
GTC Taiwan 2017 以雲端 GPU 將傳統硬體人工智慧化
GTC Taiwan 2017 以雲端 GPU 將傳統硬體人工智慧化GTC Taiwan 2017 以雲端 GPU 將傳統硬體人工智慧化
GTC Taiwan 2017 以雲端 GPU 將傳統硬體人工智慧化
 
GTC Taiwan 2017 GPU 平台上導入深度學習於半導體產業之 EDA 應用
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GTC Taiwan 2017 GPU 平台上導入深度學習於半導體產業之 EDA 應用
 
GTC Taiwan 2017 深度學習與該技術於視訊監控產業上之應用
GTC Taiwan 2017 深度學習與該技術於視訊監控產業上之應用GTC Taiwan 2017 深度學習與該技術於視訊監控產業上之應用
GTC Taiwan 2017 深度學習與該技術於視訊監控產業上之應用
 
GTC Taiwan 2017 企業端深度學習與人工智慧應用
GTC Taiwan 2017 企業端深度學習與人工智慧應用GTC Taiwan 2017 企業端深度學習與人工智慧應用
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GTC Taiwan 2017 應用智慧科技於傳染病防治
GTC Taiwan 2017 應用智慧科技於傳染病防治GTC Taiwan 2017 應用智慧科技於傳染病防治
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