The National Center for Biotechnology Information (NCBI) at the National Institutes of Health (NIH) requires high-performance storage to support genome research for its public databases and projects like the 1000 Genomes Project. NCBI's existing storage could not scale to meet the demands of projects generating over 1.5 petabytes of genetic data. NCBI implemented a Panasas storage system connected to a 1800-core Dell cluster, which improved application performance by 5 times, enabled faster database updates, and provided scalable storage for NCBI's growing archives. The Panasas solution supports NCBI's mission of advancing biomedical discovery through public databases and genome research.