This document provides information and guidance for starting a ketamine assisted psychotherapy practice. It discusses treatment indications for ketamine therapy including treatment resistant depression, anxiety, PTSD, and addictions. It also lists contraindications. Treatment approaches for ketamine are described, including low and moderate to high dosing. A sample treatment protocol is outlined involving medical and psychological assessment, in-office sessions, at-home sessions, and maintenance phases. Training resources for ketamine therapy are listed. Considerations for a ketamine practice such as vision, education, set and setting, staff training, protocols, partnerships, and adverse events are reviewed.