A ppt by Pranjali Mahajan

1. Anuradha College Of Pharmacy, Chikhli Dist. BULDANA.
Department Of Cosmetic Technology
Seminar on
LIPOSOME – CONTROLLED DRUG
DELIVERY SYSTEM
Presented by
Pranjali Rajendra Mahajan
B. Tech (Cosmetics) 7th sem
Guided by
Prof. R. D. Majeji
M. Tech (Cosmetics)

2. CONTENT
Introduction Of Liposome
Structure & Mechanism Of Liposome
Classification Of Liposome
Composition Of Liposome
Methods Of Liposome Preparation
Advantage Of Liposome
Disadvantage Of Liposome
Application Of Liposome

3. IntroductionOfLiposome
 Liposome were first produced in England in
1961 by Dr. Alec D. Bangham.
 Liposomes are concentric bi-layered vesicle in
which an aqueous volume is entirely enclosed by
membranous lipid bilayer mainly composed of
natural and synthetic phospholipid.
 The name liposome is derived from two Greek
word lipo means fat and soma means body.

4. Structure Of Liposome

5. Multilamellar Vesicles (MLV, 100nm-20nm)
Oligolamellar Vesicles (OLV, 0.1nm-1)
Unilamellar Vesicles (ULV)
Small ULV
Medium ULV
Large ULV
Classification Of Liposome

6. Structural composition of liposome includes
A. Phospholipids
B. Cholesterol
Composition Of Liposome

7. Naturally occurring phospholipids
 Phosphatidylcholine
 Phosphatidylserine
 Phosphatidylethanolamine
Synthetic phospholipids used are
 Disteroyl phosphatidylcholine
 Dioleoyl phosphatidylethanolamine
 Dioleoyl phosphatidylcholine
A-Phospholipids

8. B- Cholesterol
Stabilizes the membrane
Act as a fluidity buffer
Restrict the transformation of trans to cis
conformations

10. A) Mechanical Dispersion
Method
A-1 Hand Shaking Method

12. A-2 Sonication

13. A-3FrenchPressureCell
This Method Is Having The Mechanism Of High
Pressure.
This Method Will Give Either Uni- Or Oligo-lamellar
Liposomes Of Intermediate Size(30-80nm).
This Liposomes Are More Stable Compared To The
Sonicated Liposomes.
But this Method Is Having Some Drawback Of Initial
High Cost.

14. A-4 Micro-Emulsification

15. A-5MembraneExtrusionTechnique.

16. This technique is used to process LUVs and
MLVs.
The size of liposome is reduced by gently passing
them through membrane filter of definite pore
size at much lower pressure.
In this the vesicles content are exchanged with
the dispersion medium during breaking and
resealing of phospholipids bilayers.
As they pass through the polycarbonate
membrane they are collected in outlet.

17. B)SolventDispersionMethod
Diagram:-

18. B-1EthanolInjection

19. B-2 Ether Injection

20. B-3. Reverse Phase Evaporation Method
First water in oil emulsion is formed by brief sonication of
two phase system containing phospholipids in organic
solvent and aquous buffer.
The organic solvent are removed under reduced pressure
resulting in the formation of a viscous gel.
The liposome are formed when residual solvent is
removed by continued rotary evaporation under reduce
pressure.

21. Increased Efficacy Of Drug
It Reduces Toxicity Of Encapsulated Drug
Increase Stability Of Encapsulated Drug
It Is Targeted Drug Delivery System
It Can Carry Both Water And Lipid Soluble Drugs.
It Can Be Administered Through Various Routes.
Direct Interaction Of The Drug With Cell.
It Can Make In Verity Of Size.
Stabilization Of Entrapped Drug From External Environment.
AdvantageOfLiposome

22. Production Cost Is High
Short Life Span
Leakage & Fusion Of Encapsulated Molecules
Low Solubility.
Leakage Is Fast.
Allergic Reaction May Occurs.
Once Administrated Liposomes Can Not Be Removed.
Difficult In Large Scale Manufacturing And
Sterilization.
Disadvantages of liposome

23. Liposomes used in antiaging product
It use to maintain the stability
It used in a foot preparation
Used in antiacne product
Skin penetration enhance
It also used in a pharmaceutical purpose like eye
medicine, cancer treatment, etc.
Application of liposome

24.  Liposomes are one of the unique drug delivery
system, which can be of potential use in controlling
and targeting drug delivery.
 Liposomes are administered orally, parentally and
topically as well as used in cosmetics and hair
technologies, sustained release formulations,
diagnostic purpose and as good carriers in gene
delivery.
 Now a days Liposomes are used as versatile carriers
for targeted delivery of drug.
Conclusion

25. Jain sanjay K and Jain N.K controlled and
novel drug delivery system chapter 1
D.D application of liposome, handbook of
biological physics, volume 1.
https://www.ncbi.nlm.nih.gov/pmc/articles/P
MC3599573
Text book of industrial pharmacy by Shobha
Rani R. Hiremath, Universities press.
Reference