Anti Tubercular Therapy
Dr N Preetha MD
Assistant Professor
Department of Pharmacology
GDMC

John Hopkins university study…
TB kills 4,109 people a day.
Vs
1,449 people a day dying due to covid
Despite being both preventable and curable, TB kills around 1.5 million people each year, more than any other infectious
disease.

‘Not our problem'
• Around five percent of the 9.5 million people who contract TB
each year are resistant to ATT drugs

Tubercular infection Effective drugs
Rapidly growing, high bacillary load H > R, E , S
Slow growing- intracellular macrophages Z > H,R,E & S -
Spurters- caseous material R
Dormant Nil (bedaquiline)

Monodrug resistant TB

Polydrug resistant TB

INH resistant TB

Extensive drug-resistant TB

Role of corticosteroids in TB
• Seriously ill
• Hypersensitivity
• Extrapulmonary TB- prevent exudation/strictures
• AIDS – severe TB

TUBERCULOSIS PREVENTIVE TREATMENT

TPT

Mycobacterium Avium Complex