This presentation goes in-depth in the growing field of personal genome sequencing. The advances in high-throughput DNA sequencing has made the process of mapping structural deviations in an individual's genetic totality more economical. The advantages in health care makes this technology more like to be fully integrated in medicine within the next ten years.

1. Diego Herrera Cancer and Society

13. The graph on the left shows an inverse relationship of two factors: fiscal expense of sequencing and the number of genomes created. As the sequencing cost per base has decreased, the number of completed genomes have increased. The table on the right shows the specialized genomes that implemented recently developed high-throughput DNA sequencing techniques. This technology was not available to researchers of the Human Genome Project.

14. Step 1: Formation of DNA Nanoballs (DNBs) Each DNB contains hundreds of copies of the 70 bases sought to be read in each fragment Diameter of each spot is 300 nanometers. The space between each spot is 700 nanometers. There are 2.8 billion spots in the area of the chip: 25 millimeters wide and 75 millimeters long Step 2: Plating Fill spots with sticky DNBs. Each nanoball array chip contains 180 billion bases of genomic DNA for imaging Step 3: Imaging Detection of red, blue, green and yellow fluorescence. High accuracy makes it possible to read seven 5-base segments from two ends. Total of 70 bases read in each fragment