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HIV IN PREGNANCY


 Geneva Foundation for Medical Education
 and Research
 GFMER Sudan 2012
 Forum No: ( 2 )
NAME OF PRESENTER
Name                  Position                 Institution
Dr. Amal Khalil       Coordinator of           UMST
                      Reproductive & Child
                      Health Research Unit
                      (RCRU).


 Name of contributors
 Name                  Position                 Institution
 Dr . Hani Mohammed    Medical Director         Um Bakhita Maternity .H
 Ibrahim               Research Assistant at    UMST
                       (RCRU).
 Dr . MAJDI            Pharmacist/ MSc. Public UMST
 SABAHELZAIN           and Tropical Health
CONTENT OF THE
PRESENTATION

 MTCT
 PMTCT in Sudan

 PMTCT Centers

 Prevention of MTCT
MTCT

 largest source of HIV infection in children
  below the age of 15 years (95%).
 < 80% of MTCT occurs late in the third
  trimester, during labour and delivery.
 vaginal delivery, duration of membranes
  rupture, chorioamnionitis, preterm delivery
  and breast feeding.
INCREASED RISK OF MTCT IN


 well advanced maternal HIV disease.
 low antenatal CD4 T- lymphocyte counts .

 high mean plasma viral.
TIMING AND RISK OF
TRANSMISSION
                                            Transmission Rate

During pregnancy                            5 – 10%

During labour & delivery                    10 – 20%

During breast feeding                       5 – 20%

Overall without breastfeeding               15 – 30%

Overall with breast feeding till 6 months   25 – 35%

Overall with breast feeding till 18 to 24   30 – 45%
months
PMTCT IN SUDAN

   A pilot project was implemented in four states
    to examine the applicability of such an
    intervention before starting a nationwide
    implementation.

   result of this project was 6593 pregnant
    women counseled, 927 tested and 7 was
    found to be positive and the prevalence was
    0.76%.
PMTCT CENTERS

 2007: 7 centers in high prevalence areas of
  South Darfur, Khartoum, Kassala, North
  Kordofan and Red Sea.
 7,848 pregnant women attending had access
  to PMTCT services by receiving routine
  counseling and testing.
HIV PREVALENCE AMONG WOMEN
ATTENDING PMTCT SERVICES IN SUDAN
FROM AUGUST 2007 TO JULY 2008

Site              Total tested   Total positive    Prevalence %
Omdurman          525            12               2.28
Saudi Hospital    1159           1                0.086
Turkey Hospital   1185           4                0.34
Port Sudan        219            4                1.8
Kassala           994            8                0.8
Elobeid           497            4                0.8
Nyala             727            2                0.27
Total             5306           35               0.66
BENEFITS OF HIV TESTING FOR
PREGNANT WOMEN?
   A mother who knows early in her pregnancy
    that she is HIV infected has more time to
    make important decisions. She and her
    health care provider will have more time to
    decide on effective ways to protect her health
    and prevent mother-to child transmission of
    HIV She can also take steps to prevent
    passing HIV to her partner.
IN SUDAN…

   Awareness about mother-to-child
    transmission of HIV is 26.4%.

   Knowledge of ways of mother-to-child
    transmission of HIV (all three means of
    vertical transmission) is 54%.
SHHS 2006
State         Awareness about       Knowledge of ways of
              mother-to-child       mother-to-child
              transmission of HIV   transmission of HIV
              (%)                   (%)
Khartoum      82.1                  35.7
River Nile    75.7                  40.8
W. Darfur     21.0                  12.5
S. Kordofan   37.6                  19.8
PREVENTION OF MTCT
 using antiretroviral therapy (ART)- two
  complementary       goals:   to   prevent     the
  transmission of HIV to the unborn child and to
  safeguard the health of the mother.
 delivery by elective caesarean section.
 vaginal under certain precautions
 avoidance of breast feeding (risk highest in first
  3 months).
 Formula feeding is associated with reduction of
  MTCT to around 14%.
INFANT FEEDING
 RECOMMENDATIONS
 FOR HIV-POSITIVE WOMEN
•When replacement feeding is acceptable,
feasible, affordable, sustainable and safe,
avoidance of all breastfeeding by HIV-infected
mothers is recommended.

•Otherwise, exclusive breastfeeding is
recommended during the first months of life.
HIV in pregnancy in sudan
HIV in pregnancy in sudan

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HIV in pregnancy in sudan

  • 1. HIV IN PREGNANCY Geneva Foundation for Medical Education and Research GFMER Sudan 2012 Forum No: ( 2 )
  • 2. NAME OF PRESENTER Name Position Institution Dr. Amal Khalil Coordinator of UMST Reproductive & Child Health Research Unit (RCRU). Name of contributors Name Position Institution Dr . Hani Mohammed Medical Director Um Bakhita Maternity .H Ibrahim Research Assistant at UMST (RCRU). Dr . MAJDI Pharmacist/ MSc. Public UMST SABAHELZAIN and Tropical Health
  • 3. CONTENT OF THE PRESENTATION  MTCT  PMTCT in Sudan  PMTCT Centers  Prevention of MTCT
  • 4. MTCT  largest source of HIV infection in children below the age of 15 years (95%).  < 80% of MTCT occurs late in the third trimester, during labour and delivery.  vaginal delivery, duration of membranes rupture, chorioamnionitis, preterm delivery and breast feeding.
  • 5. INCREASED RISK OF MTCT IN  well advanced maternal HIV disease.  low antenatal CD4 T- lymphocyte counts .  high mean plasma viral.
  • 6. TIMING AND RISK OF TRANSMISSION Transmission Rate During pregnancy 5 – 10% During labour & delivery 10 – 20% During breast feeding 5 – 20% Overall without breastfeeding 15 – 30% Overall with breast feeding till 6 months 25 – 35% Overall with breast feeding till 18 to 24 30 – 45% months
  • 7. PMTCT IN SUDAN  A pilot project was implemented in four states to examine the applicability of such an intervention before starting a nationwide implementation.  result of this project was 6593 pregnant women counseled, 927 tested and 7 was found to be positive and the prevalence was 0.76%.
  • 8. PMTCT CENTERS  2007: 7 centers in high prevalence areas of South Darfur, Khartoum, Kassala, North Kordofan and Red Sea.  7,848 pregnant women attending had access to PMTCT services by receiving routine counseling and testing.
  • 9. HIV PREVALENCE AMONG WOMEN ATTENDING PMTCT SERVICES IN SUDAN FROM AUGUST 2007 TO JULY 2008 Site Total tested Total positive Prevalence % Omdurman 525 12 2.28 Saudi Hospital 1159 1 0.086 Turkey Hospital 1185 4 0.34 Port Sudan 219 4 1.8 Kassala 994 8 0.8 Elobeid 497 4 0.8 Nyala 727 2 0.27 Total 5306 35 0.66
  • 10. BENEFITS OF HIV TESTING FOR PREGNANT WOMEN?  A mother who knows early in her pregnancy that she is HIV infected has more time to make important decisions. She and her health care provider will have more time to decide on effective ways to protect her health and prevent mother-to child transmission of HIV She can also take steps to prevent passing HIV to her partner.
  • 11. IN SUDAN…  Awareness about mother-to-child transmission of HIV is 26.4%.  Knowledge of ways of mother-to-child transmission of HIV (all three means of vertical transmission) is 54%.
  • 12. SHHS 2006 State Awareness about Knowledge of ways of mother-to-child mother-to-child transmission of HIV transmission of HIV (%) (%) Khartoum 82.1 35.7 River Nile 75.7 40.8 W. Darfur 21.0 12.5 S. Kordofan 37.6 19.8
  • 13. PREVENTION OF MTCT  using antiretroviral therapy (ART)- two complementary goals: to prevent the transmission of HIV to the unborn child and to safeguard the health of the mother.  delivery by elective caesarean section.  vaginal under certain precautions  avoidance of breast feeding (risk highest in first 3 months).  Formula feeding is associated with reduction of MTCT to around 14%.
  • 14. INFANT FEEDING RECOMMENDATIONS FOR HIV-POSITIVE WOMEN •When replacement feeding is acceptable, feasible, affordable, sustainable and safe, avoidance of all breastfeeding by HIV-infected mothers is recommended. •Otherwise, exclusive breastfeeding is recommended during the first months of life.