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Cardiovascular system
Cardiovascular system
• A constant
circulation of
blood is
maintained
throughout the
body by the
heart & blood
vessels
Cardiovascular system
Primary functions of the CVS
• To supply of O2, nutrients & hormones
to various tissues in the body
• To remove the waste products from the
tissues
Heart
Heart
• Hollow muscular
organ
• Pumps blood
through the
blood vessels of
the circulatory
system
Heart
• Situated in the mediastinum in the thorax
• Lies between the 2 lungs & immediately
above the diaphragm
Pericardium
Chambers of the heart
The chambers of the heart are:
• 2 atria
• 2 ventricles
Chambers of the heart
• Oxygenated blood from the lungs
 Left side of the heart
Chambers of the heart
• Deoxygenated blood from all over the
body  Right side of the heart
Blood vessels
Types of blood vessels
Arteries
Carry the blood away from the
heart
Arterioles Smaller arteries
Capillaries
Exchange of water & chemicals
between blood & tissues occurs
Venules Smaller veins
Veins
Carry blood from the capillaries
back towards the heart
Arteries
Aorta
• Largest artery in
the body
• Carries
oxygenated
blood from the
left ventricle &
distributes it to
all parts of the
body
Parts of aorta
• Aorta, arising from
the left ventricle,
runs upwards
{ascending aorta},
arches to the left
{arch of the aorta} &
then descends
{descending aorta)
Aortic knob / knuckle
• The arch of
aorta is seen
in x-ray
chest as a
projection
beyond the
left margin of
the heart
shadow
{Aortic knob
/ knuckle}
Parts of aorta
Descending aorta is
divisible into:
• Thoracic aorta
(part above the
diaphragm)
• Abdominal aorta
(part below the
diaphragm)
Common iliac arteries
Abdominal aorta
divides into:
• Right common
iliac artery
• Left common
iliac artery
Common iliac arteries
• Division of
abdominal aorta
vertebra into
right & left
common iliac
arteries is in
front of the
body of the L4
vertebra
Common iliac arteries
• Common iliac arteries
pass downwards &
laterally
Divides in front of the
sacroiliac joint into:
• External iliac artery
• Internal iliac artery
Internal iliac arteries
• The internal
iliac arteries
supply
almost all
the pelvic
viscera
(organs)
External iliac arteries
• The external
iliac arteries
provides blood
supply to the
lower limbs & to
the muscles &
skin in the lower
abdominal wall
Veins
Veins
• Veins return blood from various tissues
to the heart
• The smallest veins {venules} unite to
form larger veins
• Veins carry deoxygenated blood (low in
O2 content) except the pulmonary veins
(which carry oxygenated blood from
the lungs to the heart)
Major veins
Two major veins in the body are:
• Superior vena cava
• Inferior vena cava
Major veins
Two major veins in the body are:
• Superior vena cava
• Inferior vena cava
Superior vena cava (SVC)
Returns blood from all
the structures above
the diaphragm (except
heart & lungs) to the
right atrium
Major veins
Two major veins in the body are:
• Superior vena cava
• Inferior vena cava
Inferior vena cava (IVC)
• Returns blood from the lower limbs,
most of the abdominal wall & the
abdominopelvic viscera
Inferior vena cava (IVC)
• Begins anterior
to the L5 vertebra
by the union of
the 2 common
iliac veins
Common iliac veins
• Common iliac
veins are formed
by the external
iliac & internal
iliac veins
• They drain blood
from the pelvis
& lower limbs
Inferior vena cava (IVC)
Passes through
the diaphragm
& enters the
right atrium of
the heart
Coronary circulation
Coronary circulation
• Coronary circulation is the circulation
of blood in the blood vessels that
supply the heart muscle (myocardium)
& other components of the heart
Coronary arteries
• Two coronary
arteries (right
& left) supply
oxygenated
blood to the
heart muscle
& other
components
of the heart
Coronary arteries
• The coronary
arteries
originate at the
beginning of
aorta (just after
aorta exits left
ventricle)
Coronary veins
• Coronary veins return deoxygenated
blood from the myocardium back to the
right atrium
Circulation of blood
Blood circulation
• Systemic circulation
• Pulmonary circulation
Blood circulation
• Systemic circulation
• Pulmonary circulation
Systemic circulation
• Oxygenated blood from the lungs 
(Through the pulmonary veins) Left
atrium  Left ventricle  Blood
pumped into aorta
Systemic circulation
• Aorta branches into
smaller arteries
• These arteries
branch & rebranch
to form arterioles
• Arterioles further
divide to form
capillaries
Systemic circulation
• Capillaries
supply blood
to various
tissues of the
body
Systemic circulation
• In the tissues, exchange of O2, CO2,
nutrients & waste products takes place
• Capillaries drain into venules
• Venules unite to form veins
Systemic circulation
• Venous blood from the upper part
of the body is drained by superior
vena cava (SVC)
Systemic circulation
• Venous blood from the lower part
of the body is drained by inferior
vena cava (IVC)
Systemic circulation
• SVC & IVC carry
deoxygenated
blood back to
right atrium
Blood circulation
• Systemic circulation
• Pulmonary circulation
Pulmonary circulation
• Deoxygenated blood from the right
atrium  Right ventricle  Blood
pumped into Pulmonary trunk
Pulmonary circulation
• Pulmonary trunk divides into
Right & left pulmonary arteries
Pulmonary circulation
• Right & left pulmonary arteries  Right
& left lungs  Branch & rebranch to
form Capillaries
Pulmonary circulation
• Exchange of
O2 & CO2 takes
place between
the blood in
the lung
capillaries &
the air in the
lung alveoli
Pulmonary circulation
• Capillaries in
the lungs,
carrying
oxygenated
blood, join to
form venules
Pulmonary circulation
• Venules unite
to form 4
pulmonary
veins (2 from
each lung) 
Left atrium 
Left ventricle
Pulmonary vessels
• Pulmonary arteries carry deoxygenated
blood
• Pulmonary veins carry oxygenated
blood
Blood
Blood
• The unique fluid nature of this tissue is
ideal for its function of transport of
substances from one part of the body
to another
• In the body of an adult male (of 70 kg
weight) there will be about 5600 ml of
blood
Blood coagulation / clotting
• Blood (though fluid in circulation) has a
tendency to solidify when taken out of
the body
• This process {coagulation / clotting}
• This property helps to prevent
excessive loss of blood from the body
Composition of blood
Composition of blood
• Plasma
• Cells
Composition of blood
• Plasma
• Cells
Plasma
• A clear, slightly yellow liquid
Blood cells
• Red blood cells /
corpuscles
(RBCs)
a{Erythrocytes}
• White blood cells
/ corpuscles
(WBCs)
a{Leucocytes}
• Platelets
a{Thrombocytes}
Blood cells
• Red blood cells / corpuscles (RBCs)
a{Erythrocytes}
• White blood cells / corpuscles (WBCs)
a{Leucocytes}
• Platelets
a{Thrombocytes}
RBCs
Normal RBC count
(millions / mm3)
• Males 4.5 - 5.5
• Females 4 - 5
Hemoglobin (Hb)
• The red color of the blood is due to the
presence of hemoglobin (Hb) in the
RBCs
• When Hb combines with O2 (in the
lungs), oxyhemoglobin is formed
• When the oxyhemoglobin is exposed to
the tissues with low O2 pressure,
oxyhemoglobin readily decomposes &
O2 is liberated
Hemoglobin (Hb)
• Normal Hb level is:
14 - 18 gm% in males
12 - 16 gm% in females
Anemia
• Anemia is the condition in which either
the RBC count or the Hb concentration
or both are decreased
Blood cells
• Red blood cells / corpuscles (RBCs)
a{Erythrocytes}
• White blood cells / corpuscles (WBCs)
a{Leucocytes}
• Platelets
a{Thrombocytes}
WBCs
• They are the body’s “soldiers” that
provide defense & immunity from
invading organisms
Types of WBCs
– Neutrophil
– Eosinophil
– Basophil
– Lymphocyte
– Monocyte
Groups of WBCs
• Granulocytes
(with granules in the cytoplasm)
• Agranulocytes
(no granules in the cytoplasm)
Granulocytes
• Neutrophil
• Eosinophil
• Basophil
Agranulocytes
• Lymphocyte
• Monocyte
WBCs
• Normal total WBC count (TC) is 4000 -
11000 / mm3
• The differential count means the
relative number of the different types of
WBCs
• 100 WBCs are counted & the
percentage of each type of WBC is
determined (e.g., lymphocytes 20%)
Blood cells
• Red blood cells / corpuscles (RBCs)
a{Erythrocytes}
• White blood cells / corpuscles (WBCs)
a{Leucocytes}
• Platelets
a{Thrombocytes}
Platelets
• Normal platelet count is 1.5-4 lakhs/mm3
Functions of platelets
• Help in hemostasis
• Can engulf some bacteria
Hemostasis
• Hemostasis means arrest of bleeding
by physiological processes
Hemostasis
When there is a small injury to the blood
vessel:
• Vasoconstriction takes place at the site
of injury
Hemostasis
• Circulating platelets get adhered to the
injury site in large numbers, forming a
platelet plug
• The platelets also secrete certain
substances which cause local
vasoconstriction
Hemostasis
• The loosely aggregated platelets in the
temporary plug are converted into a
definitive clot. This process
{coagulation / clotting}
Functions of blood
Functions of blood
• Transport of O2 & CO2:
Hemoglobin in the RBCs carries O2
from the lungs to the tissues (for
oxidation of food & production of
energy)
CO2 is carried from the tissues to the
lungs
Functions of blood
(Contd.)
• Nutritional function:
The end products of digestion
[glucose, amino acid & lipids] are
absorbed from the digestive tract and
transported to various tissues (for
growth & supplying energy)
Functions of blood
(Contd.)
• Excretory function:
Various waste products are carried
from the tissues to the excretory
organs [kidneys, skin & lungs]
• Transport of hormones:
Blood carries the hormones to their
target organs
Functions of blood
(Contd.)
• Protection / defense:
WBCs in the blood can attack the
disease causing organisms [bacteria,
virus, fungus etc.]
Functions of blood
(Contd.)
• Temperature regulation:
Blood helps in easy dissipation of heat
from warmer to cooler parts of the
body, thus helping to keep the
temperature of the body constant
(Normal body temperature is 98.40 F /
370 C)
Hematology
• Branch of science that deals with the
study of blood & blood forming tissues
Blood pressure
Arterial blood pressure
• Defined as the lateral pressure exerted
by the column of blood on the walls of
the arteries
• Expressed in mm of Hg
• Systolic BP is the maximum pressure
produced during the systolic phase of
cardiac cycle
Arterial blood pressure
• Diastolic BP is the minimum pressure
produced during the diastolic phase of
cardiac cycle
• Normal BP is 120/80 mm of Hg
• When the BP 140/90 mm of Hg, the
condition {hypertension}
Blood grouping
Blood groups
• Blood group of a person is genetically
determined
• The common systems of classification
of the types of blood are ABO system &
Rh (Rhesus) system
ABO system
• According to this system, there are 4
main blood groups: A, B, AB & O
Rh system
• According to this system the human
beings are divided into 2 groups: Rh
positive & Rh negative

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