Beta oxidation of fatty acids.

1. CH3-(CH2)12-CH2-CH2-COOH
(Palmitic acid )
CoASH
H2O
Palmityl CoA synthetase
ATP
AMP+2Pi
CH3-(CH2)12-CH2-CH2 –CO-SCoA
(Palmityl CoA )
Carnitine
CoASH CAT I
Inner mitochondrial
membrane
CH3-(CH2)12-CH2-CH2-CO-carnitine
(palmityl carnitine)
CH3-(CH2)12-CH2-CH2 –CO-SCoA
(Palmityl CoA )
CoASH
Carnitine
CAT II
CH3-(CH2)12-CH2-CH2 –CO-SCoA
(Palmityl CoA )
FAD
FADH2
Palmityl CoA
dehydrogenase
CH3-(CH2)12-CH=CH–CO-SCoA
(Enoyl CoA)
H2OEnoyl CoA
hydratase
CH3-(CH2)12-CHOH-CH2–CO-SCoA
(β-hydroxyacyl-CoA)
NAD
NADH+H
β-hydroxyacyl-CoA
dehydrogenase
CH3-(CH2)12-CO-CH2-CO-SCoA
(β-ketoacyl-CoA)
Thiolase
CoASH
CH3-(CH2)12-CO-SCoA + CH3-CO-SCoA
(Myristoyl CoA) (Acetyl CoA)
β-oxidation of fatty acids “palmitic acid”
NB: Carnitine
(CH3)3-N-CH2-CHOH-CH2-COOH
Activation of
F.A
Main reaction