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Renal Complication And Their Herbal Remedy final.pptx
1. Shikshan Prasarak Mandal’S
College of Pharmacy, Akluj
PAH, Solapur University, Solapur
Renal complications and their herbal remedy : a review
Guided by
mrs.reshma pawar
m.Pharm, PHARMACOLOGY
presented by
ayesha c shaikh
Final y.b.pharm
3. introduction
Urinary system frequently suffers from different complications include kidney
stone, drug include nephrotoxicity, diabetic complications, renal failure and
renal hypertension etc. any abnormality of the flow of urine(a kidney
stone)sets the stage of complications
•Etiology
-the cause, set of causes, or manner of adisease or condition.
•Pathophysiology
-the disordered physiological process associated with disease or injury.
•Type of kidney stone
-calcium oxalate
-uric acid
-other
•Diagnosis
--x-ray
-computed tomography
•Renal complications
4. •Nephrolithiasis means kidney stone.
•A small hard,hard deposit that formsin the kidneys and often painful when
passed.
•KidneyAZ stone are hard deposite of minerals and acids salts that stick together
in concentrated urine.
•They can be painful when passing through the urinary track , but usually don’t
cause permanent damage.
•Solid Concretion oe calculi(crystal aggregations ) formed in the kidneys from
dissolved urinary minerals.
•Urolithiasis refer to the condition of having calculi in the urinary track, which
may from or pass into the urinary bladder.
•Ureterolithiasis is the condition of having a calculus in the urether , the tube
connecting the kidneys and the bladder.
•If stones grow to sufficient size of at least 2-3 millimeters they can cause
obstruction of the ureter.
1. Nephrolithiasis
5. 2. Hypercalciurea :-
• Hypercalciurea is defined as urinary calcium excreation of greater than 200mg daily.
Hypercalciurea is arguably the most important pathophysiology risk factor in calcium stone
formation.
• Hypercalciuria can be more precisely classified according to the site of primary matabolic
arangement:-
A-Absorptive hypercalciurea
(AH), characterised by intestinal hyperabsoption of calcium.
B-Renal hypercalciuria (RH), resulting from impaired renal tubular calcium reabsorption.
C.-Resorptive hypercalciuria, caused by bone demineralization.
Hypercalciurea has a rich genetic predisposition.
Fig:1
6. 3.Hypocitraturia:-
• Hypocitraturia is defined as urinary citrate excretion of less than 320mg daily, although this
ia a somewhat arbitrary cut off, because the acid-base status of the patient strongly
determines total citrate excretion.
• Hypocitraturia is a well-knows risk factor for calcium nephroliasis, and been identified in
20% to 60% calcium stone formers.
4.Hyperoxaluria:-
• hyperoxaluria is defined as urinary oxalate excretion of greater than 40mg daily.
• hyperoxaluria is thought to increase the risk of stone formation by increasing urinary
saturation of calcium oxalate (CaOx).
•Type 1- primary hyperoxaluria is caused by a deficiency aminotransferase .
•Type 2- primary hyperoxaluria is caused by a defect in cytosolic glyoxalate reductase
or hydroxypruvate reductase.
7.
8.
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