From REG 2015 Winter Summit, Rotterdam

1. David Price, REG Chairman
2015 REG Winter Summit:
Welcome

2. Welcome!
Many Miles Travelled
to be here today.
Thank you for your
time & commitment
to REG

3. Housekeeping & “rules of engagement”
• Mobile phones
• Please switch off / to silent
• Regular coffee breaks if you do need to pick up emails
• Recording & Photography for:
o Internal reference; meeting report; newsletter & (with consent) website
• Toilets / Rest rooms
• TBC on the day
• Delegate pack
• Programme
• Abstract book – for all thematic sessions & select plenaries
• Maps – directions to dinner tonight
• Expenses form – emailed for completion on your return
• Sessions
• Q&A welcomed – discussion & debate is strongly encouraged

4. Looking back; looking forward…
2014 2015

5. 2014: off to a good start…
2015
Arch Supplement
• Published by ATS Annals
• 7 papers discussing the key
aspects of real-life research:
o Guideline limitations
o The role of RWE
o Standards
o Cost-effectiveness
EAACI 2015 Conference proposals
accepted
• Harnessing primary care databases to unpick the
complexities of allergic obstructive airway disease7 papers
discussing the key aspects of real-life research
• From efficacy-based to effectiveness-based guidelines in
asthma: a paradigm shift?

6. Initial wish in 2012/13
“Set up a short-term
initiative that will raise
the quality and profile of
real-life (respiratory)
research across the
research, political and
public arenas”
But… 2014 required
REG to recognise its
longevity…

7. 2014: REG continued to grow…
April 2014
95
Dec 2014
125
April 2014
5
Dec 2014
10
COLLABORATORS
SUPPORTERS

8. 2014: Recognising our longevity (II)
Initial Structure Constitution+

9. 2014: Recognising our longevity (II)
More formal
structure
required:
• Oversight
Committee;
• Council;
Special Interest
Leads;
• Society Leads;
• Regional
Leads;
• Guideline
Leads;
• Accreditation
Committee;
Manuscript &
Research
Review

10. 2014: “Manageable chunks”
Topic-
specific
working
groups
Child Health
Small
airways
disease
Asthma/CO
PD overlap
syndrome
COPD
Control
Adherence
Database
validation
Allergy
IPF / ILD
Standards –
REG/EAACI
Taskforce
Validation/St
andardisatio
n of Coding

11. 2014: Formalised call for research ideas
• Research Pin board
• Studies shortlisted for
funding as:
1. REG Studies (non-
commercial, with multi-
sponsors or
hands-off grant);
2. REG Collaborations
(single-sponsor, non-
commercials study), or
3. Commercial Study
(commercial/product-
specific study).

12. 2014 Research: understanding real practice
• Asthma State of the Union
• Rationale: poor control may contribute
significantly to the health and economic
consequences of asthma
• A study characterising asthma severity,
treatment and control among patients
from 153 UK primary care practices.
Addresses questions around:
o Exacerbation risk at different GINA
treatment step
o Possible over-treatment of patients
(at higher GINA step)
o Differential outcomes for smokers/non-smokers
• Submitted to EACCI 2015; Manuscript in development
CONTROL
RISK?

13. 2014: June Summit

14. 2014: June Summit

15. 2014 ERS…
• Real-life session:
The Evolving Role of Real
Life Research in Respiratory
Medicine
• Collaborators meeting
• 6 abstracts from REG
studies:
o REG Endpoint Validation
Study:
o Paediatric Asthma
Step-Up
o COPD Eosinophil Study

16. • Real-life session:
The Evolving Role of Real Life
Research in Respiratory Medicine
• Collaborators meeting
• Real-life research course – run by
Research Education Alliance –
materials to be accredited by REG
2014: APSR…

17. Looking forward…
2014
2015
To all who
contributed to
REG’s many
activities and
successes

18. • ERS session proposal submitted
• Session at the ATS – Jerry Krishnan & Barry Make
• EAACI sessions
• EAACI Taskforce completing its work
• Completion & publication of current REG studies:
o Asthma risk predictors
o Blood eosinophils in COPD
o Longitudinal bi-directional
relationship between ICS
adherence and asthma outcomes
o Asthma Endpoint Validation
o COPD risk prediction
o Devices – iHARP & Critikal
2015: lots to look forward to (I)
• More research
• More meetings
• PR-activities – make the world start to sit up and take notice
• Possible joint society taskforce application…?
• Potential Horizon 2020 bid…?

19. Next 48 hours – the summit…
• Opportunity to:
o Share and learn from each other’s data
o Identify new data resources and opportunties
o Strengthen relationships and extend our networks
o Identify new ideas and opportunities for REG and for
your own research interests
• And much more
• Hand over to Dermot Ryan for his opening talk:
Maximizing the Yield: towards
patient-centred care