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This lecture is about what is the neostigmine and what are its medical uses, mechanism of action and side effects. Neostigmine is a cholinesterase inhibitor used in the symptomatic treatment of myasthenia gravis by improving muscle tone. Neostigmine is in the cholinergic family of medications. It works by blocking the action of acetylcholinesterase and therefore increases the levels of acetylcholine. Neostigmine: Cholinesterase inhibitor = ↑ ACh Neostigmine is an anticholinesterase inhibitor and inhibits the hydrolysis of acetylcholine by competing with acetylcholine for binding to acetylcholinesterase at the site of cholinergic transmission. By reducing the hydrolysis of acetylcholine, the transmission of nerve impulses is facilitated. At the end of surgery, neostigmine has been given for the reversal of neuromuscular blocking agents with several adverse effects such as bradycardia and profuse secretion. Atropine has been used to prevent those side effects of neostigmine. Side effects titles as review: . Nausea, headache, insomnia, dry mouth, dizziness, vomiting, allergic reactions, skin rash, hot flashes, joint pain, stroke, weakness, muscle cramps, frequent urination Neostigmine is rapidly absorbed after intramuscular injection (IM). Neostigmine binding to human serum albumin is approximately 15 to 25%. Neostigmine is metabolized in the liver by microsomal enzymes. The apparent excretory half-life of neostigmine is between 24 and 113 minutes. Presented by: Mohammadsaleh Moallem

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Tendances (20)

Neostigmine - Mechanism of action, indications and side effects

Atropine slideshare

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Ketamine

Noradrenaline

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Frusemide

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Suxamethonium

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General anaesthetics

Management of stroke

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Vecuronium

Dopamine

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