Bioprocessing and its significance

Bioprocessing and its
significance

Definition of Bioprocessing
A bioprocess can be explained as a particular process that utilises
complete living cells or some of their cellular components to get
wanted items.

The process is used in the creation of nourishments, pharmaceuticals,
flavours, energy and synthetic concoctions with the guide of a
biocatalyst. A catalyst in bioprocessing can be microorganisms, plants
or creature cells in a bioreactor.

Alongside, it includes hereditary designing for the control of animals,
plants and microorganisms. Downstream handling is required to expel
debasements, mass volume decrease and concurrent convergence of
the ideal item from the bioreactor.

Upstream and Downstream Process in
Bioprocess
Cell treatment bioprocessing is an order that combines the fields of cell
treatment and bioprocessing. Cell treatment bioprocessing aims to
build up reproducible and sturdy manufacturing procedures to produce
remedial cells.

Upstream and Downstream Process in
Bioprocess
Commercially significant bioprocesses can:
• Generate items to keep up the entirety of the quality gauges of
biopharmaceutical drugs
• It can also offer clinical and industrial measures of remedial cells all
through different phases of improvement.
• Control the expense of merchandise (CoGs) of the last medication
item.

Upstream Bioprocessing
Bioprocessing hardware incorporates a wide range of gear for explicit
capacities and applications. In extensive terms and as for a procedure
stream graph, the hardware can be categorised in three categories:
• Upstream
• Downstream
• Support
Upstream gear manages the development of a host life form to deliver
a product. The product may be simply the living beings, it might be held
inward to the creature, or it may be discharged into the development
medium.

Downstream Bioprocessing
Downstream bioprocessing explains the part from the upstream where
the cell mass is handled to meet virtue and quality prerequisites. It is
typically partitioned into three primary areas: cell interruption, a
decontamination segment and a cleaning segment.

The means of downstream preparing are:
1. Insolubles are Removed
• Centrifugation
• Filtration
• Sedimentation
• Precipitation
• Electro-precipitation
• Flocculation
• Gravity settling

2. Product Isolation
• Precipitation
• Adsorption
• Solvent extraction
• Ultrafiltration

3. Purification of Product
• size inclusion
• affinity
• ion-exchange chromatography
• reversed-phase chromatography
• crystallisation
Reversed-phase chromatography

4. Polishing of the Product
• crystallization
• lyophilisation
• desiccation

Significance of Bioprocessing
Bioprocess engineering is concerned with translating biological science
into biologically based manufacturing.

OPPORTUNITIES
• Biopharmaceuticals and Biopesticides from Insect Cell-Baculovirus
System
Baculovirus-Insect Expression
System for Vaccine Production

OPPORTUNITIES
• Gene-Based Pharmaceuticals and Gene Therapy

OPPORTUNITIES
• Cell-Transplantation Therapy

OPPORTUNITIES
• New Catalysts

OPPORTUNITIES
• Cells, Organs, and Biomaterials

OPPORTUNITIES
• Transgenic Animals

OPPORTUNITIES
• Transgenic Plants

OPPORTUNITIES
• Non-traditional Organisms Living at the Extremes: Extremophiles

OPPORTUNITIES
• Energy and Renewable Resources

OPPORTUNITIES
• Agricultural Chemicals and Food

OPPORTUNITIES
• Plant-Cell Culture

OPPORTUNITIES
• Plants and Seeds

OPPORTUNITIES
• The Environment
Many environmental problems will require bioprocess
engineering.
eg.- minimization of manufacturing waste, treatment of
municipal waste, environmentally friendly manufacturing

OPPORTUNITIES
• Space
The unique problems presented by the manned exploration and colonization of
space pose major and important challenges for bioprocess engineering.

DEFENSE AND NATIONAL SECURITY
• Cleanup
The Department of Defense (DOD) and Department of Energy face enormous
problems in cleanup of military bases as they are closed or moth-balled and in
cleanup of weapons laboratories. In the former, biological methods might play
an important part.

DEFENSE AND NATIONAL SECURITY
• Chemical and Biological Warfare
A continuing problem in DOD concerns chemical and biological warfare. The
stated U.S. position is to be prepared in a defensive mode, but not to be
involved in production of biological weapons. The importance of either
chemical or biological agents as practical weapons systems remains to be
established.

Reference Book
Chapter 6 The Future | Putting Biotechnology to Work: Bioprocess
Engineering | The National Academies Press
https://www.nap.edu/read/2052/chapter/8

Bioprocessing and its significance

Bioprocessing and its significance

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Bioprocessing and its significance

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