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UniversityofCaliforniaSanFrancisco
@Ron_George
@RonaldBGeorge
Neurologic complications
associated with neuraxial
anesthesia & pregnancy
Ronald B. George, MD FRCPC
Professor, Anesthesia & Perioperative Care

Chief, Obstetric Anesthesia

Betty Irene Moore Women’s Hospital at Mission Bay

University of California San Francisco
UniversityofCaliforniaSanFrancisco@Ron_George #BelgiumOBAnes
INCIDENCE
UniversityofCaliforniaSanFrancisco@Ron_George #BelgiumOBAnes
Seizures
Peripheral
Neuropathy
Cauda
Equina
Syndrome
Meningitis
Spinal
(5,640) 0
n = 2

(0.0–12.4)
0 0
Epidural
(29,732)
n = 2

(0.0–2.4)
0 0 0
Epidural 200,000 Spinal 50,000
UniversityofCaliforniaSanFrancisco@Ron_George #BelgiumOBAnes
UniversityofCaliforniaSanFrancisco@Ron_George #BelgiumOBAnes
UniversityofCaliforniaSanFrancisco@Ron_George #BelgiumOBAnes
D’Angelo et al. Anesthesiology 2014:120;1505-12
UniversityofCaliforniaSanFrancisco@Ron_George #BelgiumOBAnes
D’Angelo et al. Anesthesiology 2014:120;1505-12
UniversityofCaliforniaSanFrancisco@Ron_George #BelgiumOBAnes
Davies et al. Clin Obstet Gynecol 2017:60;431-446
Davies et al. Anesthesiology 2009:110;131-139
UniversityofCaliforniaSanFrancisco@Ron_George #BelgiumOBAnes
• Traumatic
• CSF leal

• Nerve injury

• Infective
• Epidural Abscess

• Meningitis

• Ischemic
• Spinal Cord Injury

• Chemical
• Arachnoiditis
UniversityofCaliforniaSanFrancisco@Ron_George #BelgiumOBAnes
Neuraxial Hematoma
• Acute back / radicular pain
• Weakness / bowel & bladder
• Prompt neurosurgical
consultation and MRI imaging
• Decompression within 6-8 hours
Wong CA. BPR Clin Obstet Gyne 2010:24:367
UniversityofCaliforniaSanFrancisco@Ron_George #BelgiumOBAnes
Neuraxial Hematoma
Kreppel D, et al. Neurosurg Rev 2003;26:1–49
UniversityofCaliforniaSanFrancisco@Ron_George #BelgiumOBAnes
Guffey et al. A&A 2010:111:992
UniversityofCaliforniaSanFrancisco@Ron_George #BelgiumOBAnes
Guffey et al. A&A 2010:111:992
UniversityofCaliforniaSanFrancisco@Ron_George #BelgiumOBAnes
Epidural Abscess
• Symptoms 4-10 days following
neuraxial procedure
• Severe back pain +/- radicular
pain
• Fever, neck stiffness
• Prompt neurosurgical
consultation and MRI imaging
• Staphylococcus aureus
Royakers et al. Acta Anaesth Stand 2002;46:611-5
UniversityofCaliforniaSanFrancisco@Ron_George #BelgiumOBAnes
UniversityofCaliforniaSanFrancisco@Ron_George #BelgiumOBAnes
UniversityofCaliforniaSanFrancisco@Ron_George #BelgiumOBAnes
Magnetic Resonance Imaging
Davidson et al. A&A 2010;110:233-237
UniversityofCaliforniaSanFrancisco@Ron_George #BelgiumOBAnes
Direct Trauma
• Paraesthesia
• +/- Injection
• Conus Medullaris
Syndrome
• Numbness > Pain &
Paraesthesia
• Interspace
misidentification
• Ultrasound*
UniversityofCaliforniaSanFrancisco@Ron_George #BelgiumOBAnes
Direct Trauma
• Paraesthesia
• +/- Injection
• Conus Medullaris
Syndrome
• Numbness > Pain &
Paraesthesia
• Interspace
misidentification
• Ultrasound*
Saifuddin A. Spine 1998:23:1452-6
UniversityofCaliforniaSanFrancisco@Ron_George #BelgiumOBAnes
Direct Trauma
• Paraesthesia
• +/- Injection
• Conus Medullaris
Syndrome
• Numbness > Pain &
Paraesthesia
• Interspace
misidentification
• Ultrasound*
Broadbent CR. Anaesthesia 2000:55:1122-1126
UniversityofCaliforniaSanFrancisco@Ron_George #BelgiumOBAnes
Ischemia
UniversityofCaliforniaSanFrancisco@Ron_George #BelgiumOBAnes
UniversityofCaliforniaSanFrancisco@Ron_George #BelgiumOBAnes
UniversityofCaliforniaSanFrancisco@Ron_George #BelgiumOBAnes
UniversityofCaliforniaSanFrancisco@Ron_George #BelgiumOBAnes
“Tiger country”
UniversityofCaliforniaSanFrancisco@Ron_George #BelgiumOBAnes
Intrinsic Obstetric Palsies
UniversityofCaliforniaSanFrancisco@Ron_George #BelgiumOBAnes
Lumbrosacral Plexus
UniversityofCaliforniaSanFrancisco@Ron_George #BelgiumOBAnes
Lumbrosacral Trunk
Lumbrosacral Trunk
UniversityofCaliforniaSanFrancisco@Ron_George #BelgiumOBAnes
Lumbrosacral Trunk
Lumbrosacral Trunk
UniversityofCaliforniaSanFrancisco@Ron_George #BelgiumOBAnes
Obturator Nerve Palsy
UniversityofCaliforniaSanFrancisco@Ron_George #BelgiumOBAnes
Femoral Nerve Palsy
UniversityofCaliforniaSanFrancisco@Ron_George #BelgiumOBAnes
Femoral Nerve Palsy
UniversityofCaliforniaSanFrancisco@Ron_George #BelgiumOBAnes
Meralgia Paresthetica
UniversityofCaliforniaSanFrancisco@Ron_George #BelgiumOBAnes
Sciatic Nerve Palsy
UniversityofCaliforniaSanFrancisco@Ron_George #BelgiumOBAnes
Peroneal Nerve Palsy
UniversityofCaliforniaSanFrancisco@Ron_George #BelgiumOBAnes
Peroneal Nerve Palsy
UniversityofCaliforniaSanFrancisco@Ron_George #BelgiumOBAnes
Evaluation
UniversityofCaliforniaSanFrancisco@Ron_George #BelgiumOBAnes
Evaluation
• Motor function
• 5/5 = full power

• 4/5 = movement against resistance

• 3/5 = movement against gravity

• 2/5 = movement with gravity
eliminated

• 1/5 = trace movement

• 0/5 = no visible movement

• Reflexes
• 4/4 = hyperreflexia with clonus

• 3/4 = hyperreflexia

• 2/4 = normal when symmetric

• 1/4 = diminished but normal when
symmetric

• 0/4 = absent
• Sensory
• L1 = Inguinal crease

• L2 = Anterior thigh 

• L3 = Medial knee 

• L4 =Medial malleolus

• L5 = Dorsum web great toe 

• S1 = Lateral heel
Brief
&
Comprehensive
UniversityofCaliforniaSanFrancisco@Ron_George #BelgiumOBAnes
Foot Drop - DDx
Tsen L. Int Anesth Clinics 2002:40;67-88
UniversityofCaliforniaSanFrancisco@Ron_George #BelgiumOBAnes
Roots Sensory Motor
Lateral Femoral
Cutaneous
L2 - L3 Anterolateral Thigh N/A
Femoral L2 - L4
Anteromedial Thigh

Medial Calf
Hip Flexion

Knee Extension
Obturator L2 - L4
Medial Thigh

Medial Knee
Hip Adduction
Lumbrosacral
Plexus
L1 - S4
Lateral Leg

Dorsum Foot
Ankle Dorsiflexion

Hip Extension
Sciatic L4 - S3
Posterior Thigh

Lateral Leg
Knee Flexion
Peroneal L4 - S2
Anteriolateral Leg

Dorsum Foot & toes
Ankle Dorsiflexion

& Eversion
Posterior Tibial L4 - S3 Sole of Foot
Ankle Plantarflexion

& Inversion
UniversityofCaliforniaSanFrancisco@Ron_George #BelgiumOBAnes
UniversityofCaliforniaSanFrancisco@Ron_George #BelgiumOBAnes
Evaluation
• History and Physical Exam
• Consultation - Neurology /
Neurosurgery
• Magnetic Resonance Imaging (MRI)
• Electromyography (EMG)
Questions
Ronald.George@ucsf.edu
@Ron_George

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Childbirth related neurological injury