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Nephritis
1.
2. Nephritis: Inflammation of the
kidney, which causes impaired
kidney function. Nephritis can be
due to a variety of causes,
including kidney
disease, autoimmune disease ,
and infection. Treatment depends
on the cause.
3. Nephritis is inflammation of
the kidneys and may involve
the glomeruli, tubules,
or interstitial tissue surrounding the
glomeruli and tubules
Nephritis refers to a medical
condition characterized by an
inflammation of the kidneys.
Glomerulonephritis is an inflammation
of the glomerular capillaries.
4. overall prevalence was 4.4 per
100,000 population
7.1 per 100,000 in women,
1.4 per 100,000 in men.
5. There are different types of nephritis. Each type is based
on the part of the kidney that has been affected with the
condition. The three main areas commonly affected are the
glomeruli, tubule, and interstitial renal tissue.
Glomerulonephritis
Pyelonephritis
Interstitial Nephritis
6. This condition refers to the
inflammation of the tiny
capillaries in the kidneys called
glomeruli, which task is to filter
blood. When they become
inflamed, they are unable to
effectively filter the blood
8. Infections
Post-streptococcal glomerulonephritis.
Glomerulonephritis may develop a week or two after recovery
from a strep throat infection or, rarely, a skin infection (impetigo). To fight
the infection, your body produces extra antibodies that can eventually
settle in the glomeruli, causing inflammation.
Children are more likely to develop post-streptococcal
glomerulonephritis than are adults, and they're also more likely to recover
quickly.
Bacterial endocarditis.
Bacteria occasionally can spread through your bloodstream
and lodge in your heart, causing an infection of one or more of your
heart valves. You're at greater risk of this condition if you have a
heart defect, such as a damaged or artificial heart valve. Bacterial
endocarditis is associated with glomerular disease, but the
connection between the two is unclear.
Viral infections.
Viral infections, such as the human immunodeficiency virus
(HIV), hepatitis B and hepatitis C, can trigger glomerulonephritis
9. Vasculitis
Polyarteritis.
This form of vasculitis affects small and medium blood vessels in many
parts of your body, such as your heart, kidneys and intestines.
Granulomatosis with polyangiitis.
This form of vasculitis, formerly known as Wegener's granulomatosis,
affects small and medium blood vessels in your lungs, upper airways and kidneys.
Immune Response
Lupus
A chronic inflammatory disease, lupus can affect many parts of your body, including
your skin, joints, kidneys, blood cells, heart and lungs.
Goodpasture's syndrome
A rare immunological lung disorder that can mimic pneumonia, Goodpasture's
syndrome causes bleeding in your lungs as well as glomerulonephritis.
IgA nephropathy
Characterized by recurrent episodes of blood in the urine, this primary glomerular
disease results from deposits of immunoglobulin A (IgA) in the
glomeruli. IgA nephropathy can progress for years with no noticeable symptoms
Risk factors :
HTN-Diabetic Nephropathy - Focal segmental Glomerulo sclerosis
10. Acute glomerulonephritis
Primarily a disease of children older than 2 years of age, but it
can occur at nearly any age
Chronic glomerulonephritis:
One of a group of kidney diseases characterized by long-
term inflammation and scarring of
the glomeruli (microscopic structures in the kidney that
filter blood and produce urine). This form of kidney
disease usually develops slowly (over years) and may not
produce symptoms at the outset. When symptoms and
signs do appear, they typically include blood in the urine
(hematuria), swelling (edema), high blood pressure, foamy
urine (due to protein content), and frequent nighttime
urination.
11.
12. The primary presenting feature
:Hematuria, which may be
microscopic identifiable
through microscopic: examination or
(visible to the eye)
cola- colored Urine because of RBCs
and protein plugs or casts. (RBC casts
indicate glomerular injury.)
Oliguria : Patient has acute renal
failure
Elevated BUN and serum creatinine levels
feet are slightly swollen at night
Loss of weight and strength
increasing irritability
Increased need to urinate at night
(nocturia).
Headaches,
Dizziness
Digestive disturbances
Blood pressure may be normal or severely
elevated.
Retinalfindings include hemorrhage,
exudate, narrowed tortuous arterioles, and
papilledema.
Mucous membranes are pale because of
anemia.
Cardiomegaly, a gallop rhythm, distended
neck veins,
Crackles can be heard in the lungs
13. Fewer
Chills
Nausea
Headache
Flank pain
Cloudy urine
Foul smell – urine
Azotemia
Pyuria
Anemia
Acidosis
Proteinuria
Cerebral symptoms. Cerebral symptoms
consisting mainly of headache,
drowsiness, convulsions, and vomiting
occur in connection with hypertension in a
few cases.
14. HISTORY TAKING
PHYSICAL EXAMINATION
BLOOD TEST :
creatinine Elevated
blood urea nitrogen Elevated
Hyperkalemia due to decreased potassium
excretion, acidosis, catabolism, and excessive
potassium intake from food and medications
ABG :Metabolic acidosis from decreased acid
secretion by the kidney and inability to
regenerate bicarbonate
Anemia secondary to decreased erythropoiesis
(production of RBCs)
Hypoalbuminemia with edema secondary to
protein loss through the damaged glomerular
membrane
Increased serum phosphorus & magnesium
level due to decreased renal excretion of
phosphorus & Mg
Decreased serum calcium level (calcium binds
to phosphorus to compensate for elevated
serum phosphorus levels)
Impaired nerve conduction due to electrolyte
abnormalities and uremia
KIDNEY BIOPSY PROCEDURE
URINE TEST.
might show red
blood cells and red
cell casts in your
urine, an indicator of
possible damage to
the glomeruli.
white blood cells, a
common indicator of
infection or
inflammation,
Increased protein,
which can indicate
nephron damage.
Other indicators,
such as increased
blood levels of
creatinine or urea,
are red flags.
Imaging tests.
kidney X-ray, an
ultrasound exam or a CT
scan
16. Dietary protein is restricted when renal insufficiency and nitrogen retention
(elevated BUN) develop.
Sodium is restricted when the patient has hypertension, edema, and heart
failure.
Loop diuretic medications and antihypertensive agents may be prescribed to
control hypertension. Prolonged bed rest has little value and does not alter
long-term outcomes.
Weight is monitored daily
Initiation of dialysis is considered early in the course of the disease to keep
the patient in optimal physical condition, prevent fluid and electrolyte
imbalances, and minimize the risk of complications of renal failure
17. Pharmacological management
Antibiotic therapy to prevent streptococcal
infection ( Prophylaxis ).
Steroids to suppress immunity.
Corticosteroids. These strong anti-inflammatory drugs can
decrease inflammation
Immunosuppressive drugs. These drugs, which are related to the
ones used to treat cancer or prevent the rejection of transplanted
organs, work by suppressing immune system activity that
damages the kidneys. They
include cyclophosphamide (Cytoxan), azathioprine (Imuran) and
mycophenolate (Cellcept)
Medications to prevent blood clots or lower blood pressure if
needed
Dialysis
23. HISTORY TAKING
PHYSICAL EXAMINATION
BLOOD TEST :
creatinine Elevated
blood urea nitrogen Elevated
Hyperkalemia due to decreased potassium
excretion, acidosis, catabolism, and excessive
potassium intake from food and medications
ABG :Metabolic acidosis from decreased acid
secretion by the kidney and inability to
regenerate bicarbonate
Anemia secondary to decreased erythropoiesis
(production of RBCs)
Hypoalbuminemia with edema secondary to
protein loss through the damaged glomerular
membrane
Increased serum phosphorus & magnesium
level due to decreased renal excretion of
phosphorus & Mg
Decreased serum calcium level (calcium binds
to phosphorus to compensate for elevated
serum phosphorus levels)
Impaired nerve conduction due to electrolyte
abnormalities and uremia
KIDNEY BIOPSY PROCEDURE
URINE TEST.
might show red
blood cells and red
cell casts in your
urine, an indicator of
possible damage to
the glomeruli.
white blood cells, a
common indicator of
infection or
inflammation,
Increased protein,
which can indicate
nephron damage.
Other indicators,
such as increased
blood levels of
creatinine or urea,
are red flags.
Imaging tests.
kidney X-ray, an
ultrasound exam or a CT
scan
25. Dietary protein is restricted when renal insufficiency and nitrogen retention
(elevated BUN) develop.
Sodium is restricted when the patient has hypertension, edema, and heart
failure.
Loop diuretic medications and antihypertensive agents may be prescribed to
control hypertension. Prolonged bed rest has little value and does not alter
long-term outcomes.
Weight is monitored daily
Initiation of dialysis is considered early in the course of the disease to keep
the patient in optimal physical condition, prevent fluid and electrolyte
imbalances, and minimize the risk of complications of renal failure
26. Pharmacological management
Antibiotic therapy : sulphonamide
Steroids to suppress immunity.
Analgesics
Corticosteroids. These strong anti-inflammatory drugs can
decrease inflammation
Immunosuppressive drugs. These drugs, which are related to the
ones used to treat cancer or prevent the rejection of transplanted
organs, work by suppressing immune system activity that
damages the kidneys. They
include cyclophosphamide (Cytoxan), azathioprine (Imuran) and
mycophenolate (Cellcept)
Medications to prevent blood clots or lower blood pressure if
needed
Dialysis
27.
28. It is a kidney
disorder , in which
there is an
inflammation of
interstitial space of
renal tubules
29. Infections.
Autoimmune disorders, such as Kawasaki disease or
Sjogren syndrome.
A reaction to a medicine, such as certain antibiotics.
Too much of certain medicines. These include
diuretics (water pills) or pain relievers, such as
acetaminophen, aspirin, or a non-steroidal anti-
inflammatory drug (NSAID).
Unbalanced levels of certain nutrients in your blood.
This includes too little potassium or too much
calcium.
30.
31.
32. The primary presenting feature
:Hematuria, which may be
microscopic identifiable
through microscopic: examination or
(visible to the eye)
cola- colored Urine because of RBCs
and protein plugs or casts. (RBC casts
indicate glomerular injury.)
Oliguria : Patient has acute renal
failure
Elevated BUN and serum creatinine levels
feet are slightly swollen at night
Loss of weight and strength
increasing irritability
Increased need to urinate at night
(nocturia).
Headaches,
Dizziness
Digestive disturbances
Blood pressure may be normal or severely
elevated.
Retinalfindings include hemorrhage,
exudate, narrowed tortuous arterioles, and
papilledema.
Mucous membranes are pale because of
anemia.
Cardiomegaly, a gallop rhythm, distended
neck veins,
Crackles can be heard in the lungs
34. HISTORY TAKING
PHYSICAL EXAMINATION
BLOOD TEST :
creatinine Elevated
blood urea nitrogen Elevated
Hyperkalemia due to decreased potassium
excretion, acidosis, catabolism, and excessive
potassium intake from food and medications
ABG :Metabolic acidosis from decreased acid
secretion by the kidney and inability to
regenerate bicarbonate
Anemia secondary to decreased erythropoiesis
(production of RBCs)
Hypoalbuminemia with edema secondary to
protein loss through the damaged glomerular
membrane
Increased serum phosphorus & magnesium
level due to decreased renal excretion of
phosphorus & Mg
Decreased serum calcium level (calcium binds
to phosphorus to compensate for elevated
serum phosphorus levels)
Impaired nerve conduction due to electrolyte
abnormalities and uremia
KIDNEY BIOPSY PROCEDURE
URINE TEST.
might show red
blood cells and red
cell casts in your
urine, an indicator of
possible damage to
the glomeruli.
white blood cells, a
common indicator of
infection or
inflammation,
Increased protein,
which can indicate
nephron damage.
Other indicators,
such as increased
blood levels of
creatinine or urea,
are red flags.
Imaging tests.
kidney X-ray, an
ultrasound exam or a CT
scan
36. Dietary protein is restricted when renal insufficiency and nitrogen retention
(elevated BUN) develop.
Sodium is restricted when the patient has hypertension, edema, and heart
failure.
Loop diuretic medications and antihypertensive agents may be prescribed to
control hypertension. Prolonged bed rest has little value and does not alter
long-term outcomes.
Weight is monitored daily
Initiation of dialysis is considered early in the course of the disease to keep
the patient in optimal physical condition, prevent fluid and electrolyte
imbalances, and minimize the risk of complications of renal failure
37. Pharmacological management
Antibiotic therapy : sulphonamide
Steroids to suppress immunity.
Analgesics
Corticosteroids. These strong anti-inflammatory drugs can
decrease inflammation- CONTRA INDICATED IN DRUG
INDUCED
Immunosuppressive drugs. These drugs, which are related to the
ones used to treat cancer or prevent the rejection of transplanted
organs, work by suppressing immune system activity that
damages the kidneys. They
include cyclophosphamide (Cytoxan), azathioprine (Imuran) and
mycophenolate (Cellcept)
Medications to prevent blood clots or lower blood pressure if
needed
Dialysis
38.
39. Ineffective breathing pattern related to the inflammatory process.
Altered urinary elimination related to decreased bladder capacity
or irritation secondary to infection.
Excess fluid volume related to a decrease in regulatory
mechanisms (renal failure) with the potential of water.
Risk for infection related to a decrease in the immunological
defense.
Imbalanced nutrition less than body requirements related
to anorexia, nausea, vomiting.
Risk for impaired skin integrity related to edema and pruritus.
Hyperthermia related to the ineffectiveness of thermoregulation
secondary to infection.
40.
41. The prognosis is poor. At least 80% of people
who are not treated develop end-stage kidney
failure within 6 months. The prognosis is
better for people younger than 60 years
44. BOOK REFERENCES
1. BASVANTHAPPA, MEDICAL SURGICAL NURSING, 2NDEDITION, JAYPEE
PUBLISHERS,NEW DELHI
2. BRUNNER AND SUDDARTHS, TEXT BOOK OF MEDICAL SURGICAL NURSING,
11NTHEDITION, LIPPINCOTT WILLIAMS AND WILKINS, WOLTER KLUWER (INDIA)
PVT LTD,2008
3. DANIIEL RICK et-al, CONTEMPARARY MEDICAL SURGICAL NURSING, 2NDEDITION
2007, SWAT PRINTERS,
4. DONNA D Et-al, MEDICAL SURGICAL NURSING, 2ndEDITION WB SAUNDERS COMPANY
45. 5. ELIZEBATH A MARTIN Et-al
MINI DICTIONARY FOR NURSES, OXFORD UNIVERSITY PRESS.
6. JAYA KURUVILA, ESSENTIALS OF CRITICAL CARE NURSING, JAYPEE BROTHERS
MEDICAL PUBLISHERS PVT LTD, NEWDELHI , 2007.
7. JOYCE M BLACK, Et-all, MEDICAL SURGICAL NURSING,CLINICAL MANAGEMENT
FOR POSITIVE OUTCOMES, 8THEDITION,ELSAVIER INDIA PVT LTD, 2010.
8. MOSBY, 2006 DRUG CONSULT FOR NURSES, ELSAVIER PUBLICATIONS 2006.
9. NANCY HOLMES Et-al, MASTERING MEDICAL SURGICAL NURSING DISORDERS &
TREATMENT & NURSING TIPS ANDGUIDELINES PATIENT TEACHING AND OUT COME,
SPRINGHOUSE .
10. SANDRA N NETTINA, THE LIPPINCOTT MANUAL OF NURSING PRACTICE, 7NTH
EDITION, LIPPINCOTT PUBLISHERS, PHILADELPHIA, 2003.