This presentation focuses on the role of MRI in biomedical engineering research with examples of a few global studies and the workflow associated with a MR academic project

1. An overview of MRI in biomedical research

2. What is biomedical research?
“Biomedical research is the broad area
of science that involves the
investigation of the biological process
and the causes of disease through
careful implementation, observation,
laboratory work, analysis and testing”

3. And google scholar says ….

4. Agenda
• Overview of MRI system
• Understanding of biological process
• Developmental biology
• Understanding the cause of pathology
• Angiogenesis in cancer
• Workflow of an MRI project in biomedical research

5. Gradient
coils
Subject
Radio
frequency
coil
Magnet
Overview of a MRI system
Image courtesy: MRI scanner cutaway: Colinmcnulty.com

6. y
x
z
Larmor Equation
MagneJsm: Effect of the B0 , G.r and B1 fields

7. Overview of a MRI system
Image courtesy: MRI scanner cutaway:
Colinmcnulty.com
MIRC 7

8. hYp://embryo.soad.umich.edu/.
Developmental biology – growth of the fetus

9. Smitha R.S., et. al., ISMRM 2014
Images courtesy: Dr. Sona Pungavkar, NanavaJ Mumbai
Pathology management

10. C(t) = f(ΔR1(t))
T1 – weighted
images for
baseline
T1 shortening
contrast agent
[10] Yankeelov TE, et. al MRI;23(4). 2005
*Model implemented by Dr. Vikram Kodibagkar in MATLAB
[10]
Tissue perfusion, microvascular
density and
extravascular -extracellular volume
-- tumor staging, monitor treatment
response
Imaging cancer – dynamic contrast enhanced MRI

11. Starts at frame 6 (post-contrast)
CS
CS_Gauss
CS_Glines
CS_Thresh
DCE in acJon

12. T2w Overlay
T1w
pre-contrast
T1w
post-contrast
0 10 20 30 40 50 60
0.150
0.175
0.200
0.225
0.250
ROIIntensity
Frame #
Original Keyhole Keylines Keythresh
Gauss Glines Gthresh
Muscle
0 10 20 30 40 50 60
0.175
0.200
0.225
0.250
ROIIntensity
Frame #
Original Keyhole Keylines Keythresh
Gauss Glines Gthresh
Poorly perfused region
0 10 20 30 40 50 60
0.15
0.20
0.25
0.30
0.35
0.40
ROIIntensity
Frame #
Original Keyhole Keylines Keythresh
Gauss Glines Gthresh
Well perfused region
Imaging cancer – region wise analysis

13. Workflow of an MR project
Biomedical engg.
quesJon
Hardware – RF
coils
Pulse sequence
design – RF pulses,
trajectories
ReconstrucJon –
undersampled data
QuanJtaJon – MR
parameterizaJon
MulJ-stage
validaJon
PART II
PART III