Blood clotting

BLOOD CLOTTING When blood is shed out or collected in a container, it looses its fluidity & becomes a jelly like mass after few minutes. This process is called coagulation or clotting of blood. The clot is a mesh of thin fibrils entangling the blood cells. These fibrils consist of fibrin. The fibrin is formed from fibrinogen.

FACTORS INVOLVED IN BLOOD CLOTTING ,[object Object]

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SEQUENCE OF CLOTTING MECHANISM ,[object Object]

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Stage 1 : Formation of prothrombin activator ,[object Object],[object Object],[object Object]

EXTRINSIC PATHWAY Tissue trauma ↓ Tissue thromboplastin (Protein, Glycoprotein, Phospholipid) Factor VII-> ↓ Factor X -> Activated Factor X Calcium-> ↓ ← Factor V←Thrombin Prothrombin Activator

INTRINSIC PATHWAY ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

[object Object],[object Object],[object Object],[object Object]

Stage 2 : Conversion of prothrombin into thrombin ,[object Object]

Stage 3 : Conversion of Fibrinogen into Fibrin ,[object Object],[object Object]

[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

ANTICOAGULANTS ,[object Object]

The various anticoagulants are as follows: ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

Anticoagulants are used: ,[object Object],[object Object],[object Object]

Tests for Clotting: ,[object Object],[object Object],[object Object]

MICROVASCULATURE ,[object Object]

[object Object],[object Object]

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Blood clotting

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Blood clotting