1. Developing
Therapeutic
Approaches For
Emerging Viral
Diseases
BY ZARGULL SADEIN

2. Introduction
The twenty-first century has already recorded more than
ten major epidemic or pandemic virus emergence events,
including the ongoing and devastating coronavirus disease
2019 (COVID-19) pandemic. As viral disease emergence is
expected to accelerate, there is a need for proactive
approaches to develop broadly active family-specific and
cross-family therapeutics for use in future disease
outbreaks.

4. Challenges
RAPID
TRANSMISSION
01
ANTIVIRAL
RESISTANCE
04
VIRAL EVOLUTION
02
GLOBAL
COORDINATION
05
VACCINE
DEVELOPMENT
03

5. Importance of
Developing
Therapeutic Approaches
Mitigating Morbidity
and Mortality
Reducing economic
impact
Rapid response to
outbreaks
Building healthcare
resilience
Preventing
pandemic spread

6. 1- Antiviral Drug
2- Vaccines
3- Immune-Based Therapies
The Multifaceted
Approach:

7. Antiviral drugs target
specific components of
the viral lifecycle,
inhibiting their replication
and spread within the
host.
e.g. Remdesivir
Antiviral drugs
Vaccines stimulate the
immune system to
recognize and mount a
defense against the virus
without causing disease.
e.g. Pfizer-BioNTech and
Moderna
Vaccines
Immune-based therapies
harness the body's
immune response to fight
viral infections.
e.g. Convalescent
plasma
Immune based
therapies

8. Types of Antiviral
Therapeutics
There are two fundamental types of
antiviral therapeutics .
1. Direct-acting antivirals
2. Host-factor antivirals

10. CONCLUSION
The COVID-19 pandemic serves as a stark
reminder of the importance of developing
diverse therapeutic approaches to emerging
viral diseases.
COVID-19 response provide a blueprint for
addressing future viral threats, emphasizing
the need for swift action, international
collaboration, and the continuous advancement
of therapeutic strategies to safeguard global
health and well-being.

11. References
1. Meganck, R.M., Baric, R.S. Developing therapeutic approaches for twenty-
first-century emerging infectious viral diseases. Nat Med 27, 401–410 (2021).
2. Jones, K. E., Patel, N. G., Levy, M. A., Storeygard, A., Balk, D., Gittleman, J.
L., & Daszak, P. (2008). Global trends in emerging infectious diseases.
Nature, 451(7181), 990-993.
3. Fauci, A. S., & Morens, D. M. (2012). The perpetual challenge of infectious
diseases. New England Journal of Medicine, 366(5), 454-461.

12. THANK YOU