Hemostasis is the process which stops bleeding after an injury. Here you can get an information about hemostasis.

1. HEMOSTASIS
Stanislav Nepomnyashchikh
212 group, medical faculty

4. HEMO
= blood
STASIS
= remain

5. CLOT REMOVAL
VASOCONSTRICTION
PLUG FORMATION
CLOTTING OF BLOOD

6. VASOCONSTRICTION

8. INJURY

9. LOCAL CONTROLS
Thromboxane A2
Thx A2
INJURY

10. SYSTEMIC CONTROL
Epinephrine
Thx A2
INJURY

11. INJURY
Epinephrine
Thx A2

12. PLUG FORMATION

16. CLOTTING OF BLOOD

18. VII + Tissue factor
IX + VIII
X + V
II
Fibrin clot
Antithrombin
TFP
inhibitor
Protein S and
protein C
Fibrinolysis
INHIBITION OF EXCESSIVE
CLOTTINGDavid Lillicrap; Nigel Key; Michael Makris; Denise O'Shaughnessy (2009). Practical Hemostasis and Thrombosis. Wiley-
Blackwell. pp. 1–5

19. CLOT REMOVAL

20. tPA
tPA
Plasmin Plasmin
Plasmin
inhibitor
tPA
PAI
FDPs

21. Cesarman-Maus G, Hajjar KA (May 2005). "Molecular mechanisms of fibrinolysis".
British journal of haematology 129 (3): 307–21
…A LITTLE MORE

22. TPA
Pros: no immune
reaction
Cons: 2000$ 50 mg
Streptokinase
Pros: 2$ 136 mg
Cons: immune
reaction
Zivin JA. Ischemic cerebrovascular disease. In: Goldman L, Schafer AI, eds. Goldman's Cecil
Medicine. 24th ed. Philadelphia, PA: Elsevier Saunders; 2011: chap 414
FIBRINOLYTICS

23. Mari G, Abuhamad A, Cosmi E, Segata M, Altaye M, Akiyama M. Middle cerebral artery peak
systolic velocity: technique and variability. J Ultrasound Med. 2005 Apr;24(4):425-30.

24. Hatton, Chris (2008). Haematology (Lecture Notes). Cambridge, MA: Blackwell
Publishers. pp. 145–166
ANTICOAGULANTS

25. A NEW ERA IN ANTICOAGULANTS
Jessica L. Mega, M.D., M.P.H.; N Engl J Med 2011; 365:1052-1054

26. Wynbrandt, James; Ludman, Mark D. (1 January 2009)
BLOOD CLOTTING
DISORDERS

27. Thank you