THERAMINE is a safe and effective option for the dietary management of pain without the adverse side effects associates with opioids, NSAIDs or acetaminophen. The efficacy and safety of THERAMINE is supported by two double blind clinical trials and over a decade of clinical use. To learn more about THERAMINE please call (844) 474-3111 or visit www.medicalfoods.com.

2. www.tmedpharma.com 2
Innovative Solutions for
Improved Pain Management
•Non-Addictive
•No Reported GI Bleeds
•Reduce Inflammation
•Improve Pain Perception
•Over 26 Million Doses Taken
without a Reported Cardiac or GI Event*
* Administrations is defined as number of pills sold in 2004

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Theramine® is intended for the dietary
management of pain syndromes that include:
• Chronic Low Back Pain
• Neck Pain
• Inflammatory Pain
• Joint Pain
• Radicular Pain
Recommended Dosing:
2 capsules b.i.d.
Indication & Dosing

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Theramine® can be prescribed as an adjunct to
a low dose:
• NSAID – naproxen, ibuprofen, diclofenac, meloxicam
• Narcotic – hydrocodone, tramadol, oxycodone, fentanyl
• Anti-Epileptic – gabapentin, pregabalin
• SSRI/SNRI – duloxetine, Pristiq, Savella
Opioid Dose Titration:
Theramine can also be combined with opioid therapies as part of
a dose titration and replacement strategy.
Adjunct Therapy

5. 1. Russell IJ, Michalek JE, Vipraio GA, Fletcher EM, Wall K. Serum amino acids in fibrositis/fibromyalgia syndrome. J Rheumatol Suppl 1989;19:158-163
2. Shell, et al., “A Double-Blind Controlled Trial of a Single Dose Ibuprofen and an Amino Acid Medical Food Theramine for the Treatment of Low Back Pain; Publication pending, 2010.
In a double blind, multicenter trial, subjects with pain syndromes showed decreased levels of the
amino acids required for production of pain modulating neurotransmitters, despite having a sufficient
intake of protein indicating that the need for these amino acids are selectively increased in these
patients.1
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Theramine® Improves Amino Acid Levels
0
5
10
15
20
25
30
35
Arginine Serine Histidine Tryptophan
Ug/ml
Change in Blood Concentration of Amino Acids2
Day 1
Day 28
Normal
N=25

6. In a 28 day double blind, randomized, controlled, multicenter trial of 127 subjects with chronic
established back pain, subjects taking Theramine alone and as an adjunct to naproxen experienced
a statistically significant reduction in pain compared to once daily naproxen (250mg)1 .
1. Shell, et al.,“A Double-Blind Controlled Trial of a Single Dose Naproxen and an Amino Acid Medical Food Theramine for the Treatment of Low Back Pain”; American
Journal of Therapeutics; 2012 108-114
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Significantly Reduce Pain with Theramine®
2.95
-44
-65
-80
-70
-60
-50
-40
-30
-20
-10
0
10
Percent(%)
Reduction of Pain- Roland Morris Index
Naproxen Theramine Both
p<0.05
n=126

7. Data from a 28 day double blind, randomized, controlled trial of 127 subjects with chronic established
back pain shows that a low dose NSAID can be more effective when co-administered with Theramine.1
1. Shell, et al.,“A Double-Blind Controlled Trial of a Single Dose Naproxen and an Amino Acid Medical Food Theramine for the Treatment of Low Back Pain”; American Journal
of Therapeutics; 2012 108-114
7www.tmedpharma.com
Theramine® is an Effective Adjunct to NSAIDs1
0
0.5
1
1.5
2
2.5
3
3.5
4
4.5
5
Baseline Day 7 Day 14 Day 28
LikertScale Sequential Changes in Back Pain Walking on Flat Surface
Naproxen theramine theramine/naproxen
n= 127
p<0.01

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Reduce Inflammation with Theramine®
In this double-blind multicenter trial of 127 subjects with chronic established back pain, a marked
decrease in CRP was measured among subjects taking Theramine compared to subjects taking ibuprofen
(400mg) once daily.
60.1
-47.05
-35.99
-60
-40
-20
0
20
40
60
80
Percent(%)
Change in CRP Levls
Ibuprofen n = 43 Theramine n = 41 Combination n = 38
p<0.01
Shelll WE; Pavlik St; Roth B; Silver M; Breitstein M; May L; Silver D “ Reduction in Pain and Inflammation Associated with Chronic Low Back Pain with the use of
the Medical Food Theramine” American Journal of Therapeutics 2014.

9. Replace or Augment NSAID Therapies
• Patients who are contraindicated for NSAIDs
(High BP, Over 65, CVD, Taking Aspirin)
• Patients taking Theramine can take a very low dose
NSAID without loss of efficacy
1
Alternative to Opioid Pain Medications
• Theramine can be used as an adjunct therapy to a low
dose opioid pain medication
• Theramine can be used as a replacement therapy for
other ineffective or dangerous pain medications
10www.tmedpharma.com
1. Shell, et al. American Journal of Therapeutics; 2012 108-114 ; Theramine ibuprofen trial 2010, Unpublished.

10. Theramine is a source of amino acids,
biogenic amines, and botanicals that is
specially formulated to manage the increased
nutritional requirements of pain syndromes.
The altered metabolic processes associated
with pain syndromes and inflammatory
conditions increase the turnover rate of
arginine, choline, GABA, glutamine, histidine,
5-hydroxytryptophan, and serine. Simple
dietary modifications are not sufficient to
satisfy cellular demand and restore
homeostasis to the ascending and
descending pain pathways and inflammatory
processes.(1-4)
1. 1. Wurtman RJ. Nutrients affecting brain composition and behavior. Integr
Psychiatry 1987;5:226-238.
2. Russell IJ, Michalek JE, Vipraio GA, Fletcher EM, Wall K. Serum amino acids in
fibrositis/fibromyalgia syndrome. J Rheumatol Suppl 1989;19:158-163.
3. Zeisel SH. Dietary influences on neurotransmission. Adv Pediatr 1986;33:23-47.
4. Fernstrom JD. Dietary precursors and brain neurotransmitter formation. Annu
Rev Med 1981;32:413-425.
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Increased Nutritional Requirements

11. The Pharmacodynamic properties of
Theramine® are directly related to the effects
of amino acid and other precursors on
neurotransmitter activity which are responsible
for the induction, amplification, and mitigation
of pain.
The use of Theramine in management of pain
syndromes is supported by experimental and
clinical data which have identified specific roles
for each ingredient in the mechanism of pain
reduction.
Theramine is formulated with Targeted
Cellular Technology (TCT) a patented
integrated molecular system that delivers
milligram quantities of amino acids and other
ingredients to targeted cells in a time sensitive
manner and in specific ratios efficiently
promote neurotransmitter production.
Pharmacodynamics
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12. PRECAUTIONS AND CONTRAINDICATIONS
Theramine® is contraindicated in an extremely small number of patients with
hypersensitivity to any of the nutritional components of Theramine.
ADVERSE REACTIONS
Ingestion of L-Tryptophan, L-Arginine, or Choline at high doses of up to 15
grams daily is generally well tolerated. The most common adverse reactions of
higher doses — from 15 to 30 grams daily — are nausea, abdominal cramps,
and diarrhea. Theramine contains less than 1 gram per dose of amino acids
however, some patients may experience these symptoms at lower doses. The
total combined amount of amino acids in each Theramine capsule does not
exceed 300 mg.
Safety Information
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13. DRUG INTERACTIONS
Theramine® does not directly influence the pharmacokinetics of prescription
drugs. Clinical experience has shown that administration of Theramine may
allow for lowering the dose of co-administered drugs under physician
supervision.
OVERDOSE
There is a negligible risk of overdose with Theramine as the total amount of
amino acids in a one month supply (90 capsules) is less than 30 grams.
Overdose symptoms may include diarrhea, weakness, and nausea.
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Safety Information Cont.
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14. 15
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22. Oliverio A, Castellano C, Puglisi-Allegra S. Psychobiology of opioids. Int Rev Neurobiol 1984;25:277-337.
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24. Ribeiro JA, Sebastiao AM, de MA. Adenosine receptors in the nervous system: pathophysiological implications. Prog Neurobiol 2002;68:377-392.
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Select References

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