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DR TAREK S KOTB
MBBCH
MRCPCH.UK
NRP INSTRUCTOR
PALS INSTRUCTOR
WHY TTN
RDS AIR LEAK
PPHN
Malformations
CDH
SEPSIS
METABOLIS
M
MAS
PNEUMONIACHD
TTN IS A VERY COMMON
DISEASE, BUT OFTEN
PRESENTS A DIAGNOSTIC
AND THERAPEUTIC
DILEMMA FOR THE
CLINICIAN….
•Miller MJ, Fanaroff AA, Martin RJ: Respiratory disorders in preterm
and term infants. In: Fanaroff AA, Martin RJ, eds. Neonatal-
perinatal medicine: Diseases of the Fetus and Infant. 6th ed. St
Louis: Mosby-Year Book; 1997: 1040-65.
OBJECTIVES
1.Understand the pathophysiology of transient
tachypnea of the newborn (TTN(.
2.Identify risk factors , clinical symptoms , and
radiographic findings in infants with TTN.
3.Appreciate the differential diagnoses for TTN.
4.Describe the typical clinical course of an infant
with TTN.
INTRODUCTION
Fetal lungs are filled with liquid that is crucial for normal lung
growth.
Vascular
channels
Pulmonary
epithelial
channels
Lymphatic
channels
A DELAY IN flUID CLEARANCE LEADS TO
INEFFECTIVE GAS EXCHANGE AND RESULTS IN
RESPIRATORY DISTRESS. THIS IMPERMANENT
CONDITION OF RETAINED FETAL LUNG flUID IS
KNOWN AS TRANSIENT TACHYPNEA OF THE
NEWBORN (TTN(.
CHOOSE THE CORRECT ANSWER
THE BULK OF FLUID CLEARANCE IS
MEDIATED BY:-
1- UTERINE CONTRACTIONS
2- PASSAGE OF BABY THROUGH BIRTH
CANAL
3- CORTISOL AND CATECHOLAMINE
SURGE(MATERNAL HORMONES(
The bulk of this fluid clearance is mediated by
transepithelial sodium reabsorption through
amiloride-sensitive sodium channels in the alveolar
epithelial cells with only a limited contribution from
mechanical factors and Starling forces.
Semin Perinatol.2006Feb;30(1):34-43.
Which of the following statements
concerning the occurrence of transient
tachypnea of the newborn (TTN) is correct?
a. Female infants are at higher risk of TTN than male infants
b. Maternal gestational diabetes does not increase the risk of TTN.
c. Both small-and large-for-gestational age infants are at increased risk of
developing TTN
.
d. TTN occurs in 10% to 15% of infants born at term.
INCIDENCE
TTN is one of the most common causes of neonatal
respiratory distress.
TTN occurs in 10% of infants born between 33 and 34
weeks of gestation,
5%of infants delivered at 35to 36weeks,
And fewer than1% of all term infants
NEONATAL RISK FACTORS FOR THE
DEVELOPMENT OF TRANSIENT
TACHYPNEA OF THE NEWBORN (TTN(
•Delivery before completing 39 weeks of gestation
•Cesarean section without labor
•Prematurity
•Male sex
•Large for gestational age
•Small for gestational age
•Perinatal asphyxia
•Maternal asthma
•Maternal gestational diabetes
CLINICAL PRESENTATION
They have signs of respiratory distress such as
tachypnea (respiratory rate >60 breaths/min(,
nasal flaring,
grunting, and intercostal, subcostal, and/or suprasternal
retractions.
On auscultation, breath sounds may be diminished, crackles
may be appreciated, or lung fields may be clear. Tachycardia
may often be associated.
DIAGNOSIS
IS IT TRUE THAT TTN A DIAGNOSIS OF
EXCLUSION?
The diagnosis is made based on an infant’s
clinical
Presentation ,physical examination findings , and
chest radiography findings.
If symptoms persist beyond 72 hours after
birth ,alternative diagnosis to TTN must be
examine.
RADIOLOGICAL FINDINGS IN TTN
RADIOLOGICAL FINDINGS IN TTN
RRADIOLOGICAL FINDINGS IN TTN
RADIOLOGICAL FINDINGS IN TTN
Transient tachypnea of newborn ttn
ULTRASOUND FINDINGS IN TTN
ULTRASOUND FINDINGS IN TTN
Regular
pleural line
Numerous B
lines
Coalescent B
lines in the
basies of the
lungs
ULTRASOUND FINDINGS IN TTN
baseapex
MANAGEMENT
General management
Respiratory
Nutrition and hydration
medications
RESPIRATORY MANAGEMENT
Neonates with TTN may require noninvasive respiratory
support (eg, nasal cannula, nasal CPAP) and may need
supplemental oxygen to maintain normal oxygen saturation
levels.
If a newborn is requiring FiO2 greater than 0.40 or
endotracheal intubation, there is increased likelihood of
another cause of the child’s distress and reevaluation is
necessary.
NUTRITION
•An infant’s respiratory condition is the determining factor for receiving
enteral or IV nutrition. Often the clinical status and degree of tachypnea
make it unsafe for an infant to receive oral feeds and instead the infant
can receive nutrition via gavage feeding, IV solution, or a combination of
both.
Transient tachypnea of newborn ttn
MEDICATIONS
•Medications studied include diuretic therapy , inhaled
racemic epinephrine, and inhaled b2-agonists. A recent
systematic review analyzed the usefulness of routine
diuretic therapy for TTN and concluded that neither oral
nor IV furosemide provided any benefit by improving
symptoms or reducing duration of hospitalization
•ReKassab M, Khriesat WM, Anabrees J. Diuretics for transient tachypnoea of
the newborn. Cochrane Database Syst Rev. 2015(11): CD003064.
doi:10.1002/14651858.CD003064.pub3
MEDICATIONS
•The inhaled b2-agonist salbutamol has been studied and may have
promise as a possible treatment option to improve respiratory
symptoms associated with TTN and decrease hospital length of stay.
Nevertheless, recent systematic reviews have concluded that more
evidence is needed to confirm the efficacy and safety of inhaled
epinephrine and b2-agonists in the treatment of TTN.
•Moresco L, Bruschettini M, Cohen A, Gaiero A, Calevo MG.
Salbutamol for transient tachypnea of the newborn. Cochrane
Database Syst Rev. 2016;(5):CD011878
WHICH OF THE FOLLOWING STATEMENTS IS CORRECT
REGARDING MEDICATIONS FOR THE TREATMENT OF TTN?
A. A COCHRANE SYSTEMATIC REVIEW HAS DETERMINED
THAT INTRAVENOUS FUROSEMIDE CAN REDUCE THE
DURATION OF TACHYPNEA IN TTN BY 50% COMPARED WITH
PLACEBO.
B. TTN IS AN APPROVED INDICATION FOR INHALED NITRIC
OXIDE IN THE SETTING OF NICU ADMISSION AND NEED FOR
RESPIRATORY SUPPORT.
C. CAFFEINE HAS BEEN SHOWN IN SEVERAL RANDOMIZED
CLINICAL TRIALS TO REDUCE LENGTH OF STAY
D.MEDICATIONS SUCH AS DIURETICS AND INHALATION
AGENTS ARE NOT CURRENTLY RECOMMENDED AS
STANDARD THERAPY IN THE MANAGEMENT OF TTN
Transient tachypnea of newborn ttn
FUTURE
Studies have demonstrated an association
between TTN and subsequent development
of asthma, suggesting an underlying genetic
predisposition.
Bager P, Wohlfahrt J, Westergaard T. Caesarean delivery and risk of
atopy and allergic disease: meta-analyses. Clin Exp Allergy. 2008;
38(4):634–642
MESSAGE
It can be challenging to diagnose and provide optimal
treatment for transient tachypnea of the newborn.
IT IS THE TIME FOR NEONATOLOGISTS TO USE BEDSIDE US
IN NICUS
Transient tachypnea of newborn ttn

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Transient tachypnea of newborn ttn

  • 1. DR TAREK S KOTB MBBCH MRCPCH.UK NRP INSTRUCTOR PALS INSTRUCTOR
  • 2. WHY TTN RDS AIR LEAK PPHN Malformations CDH SEPSIS METABOLIS M MAS PNEUMONIACHD
  • 3. TTN IS A VERY COMMON DISEASE, BUT OFTEN PRESENTS A DIAGNOSTIC AND THERAPEUTIC DILEMMA FOR THE CLINICIAN…. •Miller MJ, Fanaroff AA, Martin RJ: Respiratory disorders in preterm and term infants. In: Fanaroff AA, Martin RJ, eds. Neonatal- perinatal medicine: Diseases of the Fetus and Infant. 6th ed. St Louis: Mosby-Year Book; 1997: 1040-65.
  • 4. OBJECTIVES 1.Understand the pathophysiology of transient tachypnea of the newborn (TTN(. 2.Identify risk factors , clinical symptoms , and radiographic findings in infants with TTN. 3.Appreciate the differential diagnoses for TTN. 4.Describe the typical clinical course of an infant with TTN.
  • 5. INTRODUCTION Fetal lungs are filled with liquid that is crucial for normal lung growth. Vascular channels Pulmonary epithelial channels Lymphatic channels
  • 6. A DELAY IN flUID CLEARANCE LEADS TO INEFFECTIVE GAS EXCHANGE AND RESULTS IN RESPIRATORY DISTRESS. THIS IMPERMANENT CONDITION OF RETAINED FETAL LUNG flUID IS KNOWN AS TRANSIENT TACHYPNEA OF THE NEWBORN (TTN(.
  • 7. CHOOSE THE CORRECT ANSWER THE BULK OF FLUID CLEARANCE IS MEDIATED BY:- 1- UTERINE CONTRACTIONS 2- PASSAGE OF BABY THROUGH BIRTH CANAL 3- CORTISOL AND CATECHOLAMINE SURGE(MATERNAL HORMONES(
  • 8. The bulk of this fluid clearance is mediated by transepithelial sodium reabsorption through amiloride-sensitive sodium channels in the alveolar epithelial cells with only a limited contribution from mechanical factors and Starling forces. Semin Perinatol.2006Feb;30(1):34-43.
  • 9. Which of the following statements concerning the occurrence of transient tachypnea of the newborn (TTN) is correct? a. Female infants are at higher risk of TTN than male infants b. Maternal gestational diabetes does not increase the risk of TTN. c. Both small-and large-for-gestational age infants are at increased risk of developing TTN . d. TTN occurs in 10% to 15% of infants born at term.
  • 10. INCIDENCE TTN is one of the most common causes of neonatal respiratory distress. TTN occurs in 10% of infants born between 33 and 34 weeks of gestation, 5%of infants delivered at 35to 36weeks, And fewer than1% of all term infants
  • 11. NEONATAL RISK FACTORS FOR THE DEVELOPMENT OF TRANSIENT TACHYPNEA OF THE NEWBORN (TTN( •Delivery before completing 39 weeks of gestation •Cesarean section without labor •Prematurity •Male sex •Large for gestational age •Small for gestational age •Perinatal asphyxia •Maternal asthma •Maternal gestational diabetes
  • 12. CLINICAL PRESENTATION They have signs of respiratory distress such as tachypnea (respiratory rate >60 breaths/min(, nasal flaring, grunting, and intercostal, subcostal, and/or suprasternal retractions. On auscultation, breath sounds may be diminished, crackles may be appreciated, or lung fields may be clear. Tachycardia may often be associated.
  • 13. DIAGNOSIS IS IT TRUE THAT TTN A DIAGNOSIS OF EXCLUSION? The diagnosis is made based on an infant’s clinical Presentation ,physical examination findings , and chest radiography findings. If symptoms persist beyond 72 hours after birth ,alternative diagnosis to TTN must be examine.
  • 20. ULTRASOUND FINDINGS IN TTN Regular pleural line Numerous B lines Coalescent B lines in the basies of the lungs
  • 21. ULTRASOUND FINDINGS IN TTN baseapex
  • 23. RESPIRATORY MANAGEMENT Neonates with TTN may require noninvasive respiratory support (eg, nasal cannula, nasal CPAP) and may need supplemental oxygen to maintain normal oxygen saturation levels. If a newborn is requiring FiO2 greater than 0.40 or endotracheal intubation, there is increased likelihood of another cause of the child’s distress and reevaluation is necessary.
  • 24. NUTRITION •An infant’s respiratory condition is the determining factor for receiving enteral or IV nutrition. Often the clinical status and degree of tachypnea make it unsafe for an infant to receive oral feeds and instead the infant can receive nutrition via gavage feeding, IV solution, or a combination of both.
  • 26. MEDICATIONS •Medications studied include diuretic therapy , inhaled racemic epinephrine, and inhaled b2-agonists. A recent systematic review analyzed the usefulness of routine diuretic therapy for TTN and concluded that neither oral nor IV furosemide provided any benefit by improving symptoms or reducing duration of hospitalization •ReKassab M, Khriesat WM, Anabrees J. Diuretics for transient tachypnoea of the newborn. Cochrane Database Syst Rev. 2015(11): CD003064. doi:10.1002/14651858.CD003064.pub3
  • 27. MEDICATIONS •The inhaled b2-agonist salbutamol has been studied and may have promise as a possible treatment option to improve respiratory symptoms associated with TTN and decrease hospital length of stay. Nevertheless, recent systematic reviews have concluded that more evidence is needed to confirm the efficacy and safety of inhaled epinephrine and b2-agonists in the treatment of TTN. •Moresco L, Bruschettini M, Cohen A, Gaiero A, Calevo MG. Salbutamol for transient tachypnea of the newborn. Cochrane Database Syst Rev. 2016;(5):CD011878
  • 28. WHICH OF THE FOLLOWING STATEMENTS IS CORRECT REGARDING MEDICATIONS FOR THE TREATMENT OF TTN? A. A COCHRANE SYSTEMATIC REVIEW HAS DETERMINED THAT INTRAVENOUS FUROSEMIDE CAN REDUCE THE DURATION OF TACHYPNEA IN TTN BY 50% COMPARED WITH PLACEBO. B. TTN IS AN APPROVED INDICATION FOR INHALED NITRIC OXIDE IN THE SETTING OF NICU ADMISSION AND NEED FOR RESPIRATORY SUPPORT. C. CAFFEINE HAS BEEN SHOWN IN SEVERAL RANDOMIZED CLINICAL TRIALS TO REDUCE LENGTH OF STAY D.MEDICATIONS SUCH AS DIURETICS AND INHALATION AGENTS ARE NOT CURRENTLY RECOMMENDED AS STANDARD THERAPY IN THE MANAGEMENT OF TTN
  • 30. FUTURE Studies have demonstrated an association between TTN and subsequent development of asthma, suggesting an underlying genetic predisposition. Bager P, Wohlfahrt J, Westergaard T. Caesarean delivery and risk of atopy and allergic disease: meta-analyses. Clin Exp Allergy. 2008; 38(4):634–642
  • 31. MESSAGE It can be challenging to diagnose and provide optimal treatment for transient tachypnea of the newborn. IT IS THE TIME FOR NEONATOLOGISTS TO USE BEDSIDE US IN NICUS

Notes de l'éditeur

  1. When infants are delivered near-term, especially by cesarean section (repeat or primary) before the onset of spontaneous labor, the fetus is often deprived of these hormonal changes, making the neonatal transition more difficult.