American Society of Human Genetics (ASHG) 2011
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Use of the NCBO Annotator to perform enrichment analysis with the Human Disease Ontology.
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American Society of Human Genetics (ASHG) 2011
- 1. The NCBO Annotator and Enrichment Analysis with the Human Disease Ontology Trish Whetzel, Paea LePendu, Ray Fergerson, Mark Musen, Nigam Shah Stanford University, Stanford, CA 250+ Biomedical Ontologies • Create clean lexicons • Normalize via mappings • Aggregate via hierarchies 1 Pattern Analysis 1.04–million patients • Use temporal ordering NCBO Annotator Workflow 2.8–million terms 9.5–million clinical notes • Adds negation detection • Processes 1–million notes per hour 2 Patient t0 t1 … tn Acknowledgements The National Center for Biomedical Ontology is one of the National Centers for Biomedical Computing supported by the NHGRI, the NHLBI, and the NIH Common Fund under grant U54-HG004028. 1 A,B,X B,X,Y … A,X 2 B,X,Z C,Z … B,C 3 A,C,Y B,Z … X Drug Safety Off-label Drug Use 3 Enrichment Analysis For more information on the NCBO, visit http://www.bioontology.org or email support@bioontology.org