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Mixed odontogenic tumor
1. Mixed Odontogenic
Tumors
This group of tumors
is composed of
proliferating
odontogenic
epithelium in a
cellular
ectomesenchyme
resembling the dental
papilla.
Clinical features
Histopathology
Posterior mandible 70%.
Small (asymptomatic) – Large
(Local swelling / failure of
eruption).
Well defined RL with sclerotic
borders.
50% assoc. with unerupted teeth.
Encapsulated.
.has general features of
ameloblastic fibroma but containing
enamel and dentin.
5-12 yrs.
Premolar/molar region of both jaws
Well defined unilocular RL with
calcified radiopaque material
(mixed).
The most common odontogenic
tumor.
Developmental anomaly
(hamartoma).
Treatment
Males.
2-Ameloblastic Fibroodontoma.
1st & 2nd decade.
1-Ameloblastic
Fibroma.
types
3-Odontoma
2nd decade.
Maxilla.
Conservative
surgical excision.
20% recurrence
(some surgeons
recommend
more aggressive
approach).
Conservative
curettage.
Foci of enamel & dentin
in epithelial structure.
Prognosis is
excellent
Compound: enamel,
dentin, & cementum
arranged in recognizable
tooth forms.
Complex: enamel,
dentin, & cementum
arranged in a random
manner (no resemblance
to tooth).
-Compound odontoma:
Multiple small & malformed
tooth-like structures are
formed creating a “bag of
marbles” radiographic
appearance.
-complex odontoma:
Conglomerate mass of ename
& dentin, which bears no
Simple local
excision.
Prognosis is
Excellent.
2.
Compound (anterior maxilla).
Complex (posterior of both jaws).
Assoc. with unerupted tooth / block
eruption.
Odontogenic differentiation is fully
expressed.
Mostly radiodense.
RL with well defined, smooth
contours / later a well defined
radiopaque appearance.
Compound shows apparent tooth
shapes while complex appears as a
uniform opaque mass.
Asymptomatic.
Arise from altered fibroblast or
myofibroblast that produce excess
of mucopolysaccharides &
incapable of producing mature
collagen.
4-odontogenic
myxoma.
Benign, locally aggressive in bone
or soft tissues.
20-40 yrs.
Female.
Posterior mandible 28%
Unencapsulated, locally
infiltrating tumor.
Small (unilocular)
anatomic resemblance of tooth.
Stellate, spindle-shaped
& round cells in myxoid
stroma with few collagen
bundles.
It might be confused with
chondromyxoid fibroma
or with myxoid change in
an enlarged dental
follicle or papilla.
Small:
Curettage.
Large:
Surgical excision.
25% recurrence.
Prognosis is
good
3.
Purely RL.
Well circumscribed, expanding,
detructive lesion.
Maxillary lesion may extend to
sinus, nasal cavity, orbit, or cranial
cavity.
5-Cementoblastoma
(true cementum)
Large (multilocular).
Teeth displacement / root
resorption.
2nd & 3rd decades.
Roots of mandibular posterior teeth.
Slow growing / local expansion.
Asymptomatic (may be pain).
Radiographically: ball of dense
material attached to the end of root.
(opaque lesion). Opaque spicules
radiate from the central mass.
Mineralized materials.
Multinucleated giant
cells.
This lesion resemble
Osteoblastoma.
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Surgical removal
(of tooth together
with mass).
Prognosis is
excellent