5. Papillary hyperplasia
Histopathology
Small papillary projections covered with SSE
Stroma is well vascularized
Epithelium is hyperplastic with pseudoepitheliomatous features
No evidence of dysplasia
Pseudoepitheliomatous
epithelium
Epithelial dysplasia
Mild, moderate and
severe
Malignant invasion of
epithelium
7. Condyloma Latum
Etiology: Secondary syphilis
Clinically: Most common in the perianal area
Orally: Smooth, lobulated or mushroom-like mass
HP: Acanthosis, intra- and intercellular edema,
inflammatory cell infiltration
Treatment: It will regress after the treatment of syphilis
Intracellular
intercellular
9. Squamous Papilloma
Clinical features
Most common papillary lesion of the oral mucosa
Palate, lip and vermilion and other parts of oral mucosa
Generally single and less than 1 cm.
Cauliflower-like surface
15. Condyloma Acuminatum
• Clinical features
Common in the anogenital region and
may involve oral mucosa
Early stage: multiple pink nodules
Later it grows and coalesce to become:
Soft, broad-base papillary growth
16. Condyloma Acuminatum
• Histopathology
Papillary projections covered by hyperplastic SSE
Might be keratinized or non-keratinized
Upper level of epithelium demonstrate perinuclear
cellular vacuolization [koilocytic cells]
Vascularized stroma with inflammatory infiltration
Koilocytic cells
22. Keratoacanthoma
Etiology
Benign lesion
Common at sun exposed skin and less on the
vermilion
Rarely on oral mucosa in such case it may
originate from Fordyce’s granules
Other etiologic agents:
Viral infection
trauma
Chemical irritation …etc.
27. Verrucous carcinoma
Clinical features
5% of oral SCC
Common sites: buccal mucosa and gingiva
Early stage [verrucous hyperplasia] is benign or may
arise from leukoplakia
• Indurate firm with invasion to the subjacent tissue
•
•
•
31. Pyostomatitis vegetans
Clinical features
Erythematous and edematous oral
mucosa
Multiple yellow pustules 2-3 mm
Papillary projections of oral mucosa
male are more affected than female with
mean age of 34 years