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What is meant by ‘predatory publisher’? Who is preyed on and by whom? What are the consequences of this publishing phenomenon? The Director of the US ISSN Center will draw on the experience of the ISSN Network and National Library of Medicine (NLM) to explore these issues. Criteria for inclusion in NLM’s indexes and the Directory of Open Access Journals (DOAJ), as well as criteria for denying or revoking an ISSN, will be outlined. Statistics on the ubiquity and longevity of these publications, their impact on ISSN and NLM, and the role of librarians will be discussed.