Dr. Asel Sartbaeva (Reader in Chemistry Department of Chemistry, University of Bath) at the 5th Saving Lives Sustainably Global Forum 2022 on 23 November 2022.

1. Asel Sartbaeva
Vaccine supply chain:
challenges and opportunities

2. Under-five deaths from vaccine preventable diseases
worldwide
Pneumonia
45%
Measles
3%
Diarrhoea
24%
Meningitis
8%
Tetanus
3%
Whooping
cough
1%
Other
16%
Source: WHO
DTP vaccine under 5 - coverage in 2018

3. Problem: vaccine cold chain
Today more than 50% of vaccines are wasted due to failures in cold chain transport and storage
[World Health Organization].
waste
~5%
waste
~75-83% (90s)
~40-50%(00s)

5. Vaccination program successes
Small pox Polio Rinderpest
all three diseases have vaccines stable at room temperature

6. Vaccine Thermal stabilisation methods
Thermostable vaccines: an innovative concept in vaccine development Ravinder Kumar, Vartika Srivastava, Piyush Baindara & Aijaz
Ahmad Expert Review of Vaccines, Volume 21, 2022

7. Ensilication method
• Tailored growth of silica around individual vaccine components
• Silica shell physically prevents the vaccine protein from denaturation (unfolding
and aggregation)

8. in vivo TTCF
***
**
ns
0
20
40
60
80
100
120
0 10 20 30 40 50
anti-TTCF
IgG
response
(RU)
Time (days)
native
heated native
ensilicated
ensilicated heated
Doekhie A., Dattani R., Chen Y-C., Yang Y., Smith A., Silve A.P., Koumanov F. , Wells S.A., Edler K.J., Marchbank K.J., van den Elsen J, Sartbaeva A.
“Ensilicated tetanus antigen retains immunogenicity: in vivo study and time-resolved SAXS characterization” Scientific Reports 10, 9243, 2020.

9. THANK YOU
www.ensilitech.com
@AselSartbaeva
@EnsiliTech
@SartbaevaGroup