1. Presented by :
Venkatesh . Y
Regd no. 104Q1R0033,
III / I B.Pharmacy,
Narayana Pharmacy College,
Nellore.
GUIDE :
SK. Raziya Begum,
Assistant Professor,
Dept of Pharmaceutics,
Narayana Pharmacy College,
Nellore.

2. OUTLINES
Definition
Electrospinning
Process
Materials
Application in drug delivery
Venkatesh . Y, III/I B.Pharmacy, Narayana Pharmacy College, Nellore

3. DEFINITION
Nanofibers are the ultra fine solid fibers having
very small diameters that is lower than 100nm.
Human hair
Nanofibers
Venkatesh . Y, III/I B.Pharmacy, Narayana Pharmacy College, Nellore
definition

4. ELECTROSPINNIG SET UP
2
1
3
Mainly 3 elements :
1. An Electrical generator
or high voltage supplier
2. A Jet source or capillary
3. A metal collector
or target
Venkatesh . Y, III/I B.Pharmacy, Narayana Pharmacy College, Nellore
ELECTROSPINNING EQUIPMENT

5. Electrical generator :
A High Voltage Supply (0-40kv) with a low current output was
employed in the current study.
Jet source :
2ml glass syringe, needle of different gauge sizes
Metal Collector :
copper plate covered with aluminum foil placed at a predetermined
distance from the needle tip.
high voltage was discharged by using discharge pen.
Venkatesh . Y, III/I B.Pharmacy, Narayana Pharmacy College, Nellore
ELECTROSPINNING apparatus

6. ELECTROSPINNIG PROCESS
PRINCIPLE : The process makes use of
electrostatic and mechanical force to spin fibers
from the tip of the jet source. The solution is
usually electrically charged by generator. When
the electrostatic repelling force exceeds the
surface tension of the polymer solution, the
droplet is stretched into a cone ( called taylor
cone) and a solution stream is ejected and forms
an extremely fine continuous filament………
Venkatesh . Y, III/I B.Pharmacy, Narayana Pharmacy College, Nellore
OPERATING PROCESS

7. Nanofibers
Venkatesh . Y, III/I B.Pharmacy, Narayana Pharmacy College, Nellore

8. ELECTROSPINNIG POLYMERS
NATURAL SYNTHETIC
 Elastin
 Gelatin
 Collagen
 Polyvinylpyrrolidone
 Polyglycolic acid (PGA)
 Polylactic acid (PLA)
 PGA – PLA
 Polycaprolactone
 Polydioxanone
Venkatesh . Y, III/I B.Pharmacy, Narayana Pharmacy College, Nellore

9. Characteristics of Nanofibers
Surface area
Porosity
Flexible & Rigid
Venkatesh . Y, III/I B.Pharmacy, Narayana Pharmacy College, Nellore

10. APPLICATIONS IN DRUG DELIVERY
Venkatesh . Y, III/I B.Pharmacy, Narayana Pharmacy College, Nellore

11. Recently Nanofibers are used in the healthcare systems, as a tool
for drug delivery system in various diseases.
The use of Nanofibers proves the importance and convenience of
them as drug carriers.
The smaller size plays an important role in delivering the drug to
the appropriate site in the body.
Some properties of Nanofibers which are useful for drug delivery
are as follows :
→A large specific surface area
→Nanofiber diameter, 1-100nm
Venkatesh . Y, III/I B.Pharmacy, Narayana Pharmacy College, Nellore

12. Protect the drugs from Systemic decomposition
e.g., in the blood circulation.
Venkatesh . Y, III/I B.Pharmacy, Narayana Pharmacy College, Nellore

13. Controlled release of the drug at a constant
rate over a longer period of time.
Drug release only on the targeted body area.
Permeate certain membranes or barriers
e.g. BBB
Venkatesh . Y, III/I B.Pharmacy, Narayana Pharmacy College, Nellore

14. Venkatesh . Y, III/I B.Pharmacy, Narayana Pharmacy College, Nellore
Application of water soluble polymer-
based nanofibers prepered by eletrostatic
spinning as a means of altering the
dissolution rate of the poorly water
soluble drug, ITRACANAZOLE. The
process is organic based solutions of
itraconazole/HPMC mixtures were
eletrostatically spun at 16 and
24kV….RESEARCH ARTICLE BY
GEERT VERRECK.
Carbon based nanofibers – AKRON
Company
RESEARCH DRUGS

15. Conclusion
Electrospinning is a very simple and versatile method of
creating polymer-based high functional and high performance
Nanofibers that can revolutionize the world of structural
materials.
The various approaches should be developed for scientific
understanding, engineering control and then potential
implementation in devices of Electrospun nanofibers.
MERITS
DEMERITS
• Simple
• Low energy consumption
• Laboratory scale
• Hazardous organic solvents
Venkatesh . Y, III/I B.Pharmacy, Narayana Pharmacy College, Nellore
CONCLUSION

16. references
1. Dhaval B. Patel , Rahul Deshmukh,Prashant K. Pawde1, Sandip Tadavi, Rajeshwar
V.Kshirsagar; Nanofibers As Drug Delivery System, Journal of Pharmacy Research, 2009,
2(7),1184-1187.
2. Audrey Frenot, Ioannis ,S. Chronakis; Polymer nanofibers assembled by electrospinning,
Current Opinion in Colloid and Interface Science ,2003 ,8,
64–75.
3. Thandavamoorthy subbiah, G.S.Bhat, R.W.Tock ; Electrospinning of nanofibers, Journal of
Applied Polymer Sciences , 2005, Vol.96,557-569.
4. Sangamesh G. Kumbar, Syam P. Nukavarapu, Roshan James, Recent Patents on Electrospun
Biomedical Nanostructures; Recent Patents on Biomedical Engineering 2008, 1, 68-78.
5. C. K. S. Pillai and Chandra P. Sharma ; Electrospinning of Chitin and Chitosan Nanofibers;
Trends Biomater. Artif. Organs, 2009, Vol.22 (3), 179-201.
6. www.nano-ram.org
7. Google Images
20/21
Venkatesh . Y, III/I B.Pharmacy, Narayana Pharmacy College, Nellore

17. THANK YOU