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Cell Injury  Inflammation
Cell Death
Healing
Healing
Healing
Response to injury in an attempt to
restore normal structure & function.
Regeneration
and
Repair
Wound Healing
•Primary Union
•Secondary Union
Primary Union
• (Healing by first intention)
• Clean, surgically incised wound.
• Minimal loss of cells n tissue.
Steps in Primary wound
healing
• Initial hemorrhage
• Acute inflammatory response:
Neutrophils - macrophages
• Epithelial changes: new
multilayered epithelium in 5
days.
• Organization: Fibroblasts and
collagen fibres.
Injury
0 3 5 7
Acute Inflammation
Initial hemorrhage
Neutrophils
replaced by
macrophages
Fibroblast
invasion
Multilayered new
epidermis formation
Collagen fiber
formation
Scar tissue
formation
Secondary union
• Open wound, large tissue deficit.
• Extensive loss of cells n tissue
Steps:
• Initial hemorrhage
• Inflammatory phase
• Epithelial changes
• Granulation tissue
• Wound contraction
Granulation tissue formation
Granular Red appearance is due
to newly formed blood capillaries.
Contraction of wound
• Contraction Due to –
Dehydration, Collagen
contraction, Myofibroblasts.
• Starts after 2,3 days.
• Complete by 14th day.
• ~ Rapid healing
Factors influencing Healing
Local factors:
• Infection
• Blood supply
• Foreign body
• Movement
Factors influencing Healing
Systemic factors
• Age
• Nutrition
• Systemic infection
• Diabetes
Complications of wound
healing
• Infection
• Pigmentation
• Hypertrophied scar (Keloid)
• Neoplasia
• Excessive contraction
Keloid
Keloid Sole foot

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