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Bio Fund
Bio startups that operate like software startups
The emerging macro trend: Bio 2.0
Bio in 2015 is like software in 2005
So...
Storage cost-performance and computing cost-performance
Moore’s law: cost of storage, compute ⇒ zero
0.01
0.1
1.
10.
100.
...
Silicon content: $20-22
NAND Flash
$18-20
Display
$15-17
Applications Processor
$8-10
DRAM
$10-13
Baseband
$4-5
RF and FEM...
Side benefits of Moore’s law: cost of sensors ⇒ zero
Source: Qualcomm
IntegratedSensors,UserExperiences
Ambient Light
Acce...
Beyond Moore’s law: cost of sequencing ⇒ zero
Source: Nature, 2014
Cost of genome
sequencing.
Next generation
sequencers e...
Putting these trends together
This is disrupting traditional biotech
= SOFTWARE IS EATING BIO
Compute Sensors Biology
+ +
Bio 2.0 is not Biotech
BIOTECH STARTUPS SOFTWARE STARTUPS
Subject Uncontrollable organisms Perfectly determinate code
Envi...
Eroom’s law: $/drug exponentially increasing
Source: Nature Biotechnology
$10M
$100M
$1,000M
$10,000M
1949.97 1970.05 1990...
Bio in 2015 is like software in 2005
SOFTWARE IS EATING BIO
EROOM’S = NO MOORE’S = YES
The emerging macro trend: Bio 2.0
Three emerging areas
Cloud Biology Computational MedicineDigital
Therapeutics
Slow and expensive to develop
Toxic side effects
FDA regulated
Traditional therapeutics
IMAGE: Champlax
Title Text
Subtitle text
Digital therapeutics for chronic
disease
Mobile enables traction, patient
success, and a new mode...
Large capital outlay
Poor reproducibility
Empirically driven
doesn’t scale
The four horsemen of Eroom’s law
Traditional bi...
Title Text
Subtitle text
Biology that works like programming:
Cloud experiments run through software
Cloud biology
IMAGE: ...
Tsunami of data
Flood of new drugs
Traditional medicine
Title Text
Subtitle text
Personalized cancer treatments based on
patient tumor genetic screenings
Computational biomedicine
New a16z fund for Bio 2.0
Vijay Pande new GP:
uniquely suited for Bio 2.0
a16z approach
applied to Bio
Bio 2.0 software +
...
Title Text
Subtitle text
Vijay Pande:
Bio2.0 background
Chemistry
Camille and Henry Dreyfus Professor, Stanford Univ.
Thomas Kuhn Paradigm Shift Aw...
Title Text
Subtitle text
Crowd sourced computational
biology for biomedicine
Anticipated the future
Cloud before Loudcloud...
Title Text
Subtitle text
$900M
Next generation approaches to
therapeutics for infectious disease
Computation at its heart
...
Vijay Pande – Bio & IT entrepreneur
ADVISOR TO STARTUPS IN BIO
Acumen Pharmaceuticals (Alzheimer’s
Disease)
Counsyl (Carri...
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Storage cost-performance and computing cost-performance Software is Eating Bio

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Storage cost-performance and computing cost-performance
Moore’s law: cost of storage, compute ⇒ zero
0.01
0.1
1.
10.
100.
1000.
1994 1996 1998 2000 2002 2004 2006 2008 2010 2012
Dollars($)
Compute cost ($ per 1 million transistors)
Storage cost ($ per gigabyte)

Publié dans : Sciences, Technologie, Santé

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