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Connecting Midwest High Tech
    Startups With India

 MRUN Conf -             Oct 12, 2012

      Dinesh Jain, Founder CEO
      Aagami, Inc.
          …LifeSciences Catalyst
Topics covered
 India – an Introduction
 IN Lifesciences Industry snapshot
 Major centers of Lifesciences in India
 Major Deals and Investments showing
   India as a Market Place
   India as a Resource Place
 What Indian LS firms are looking for
 How Aagami Supports Companies
             Lifesciences Catalyst     2
India – a Brief Introduction (V-IMP)
Nation of 1.22 Billion people (~EU+Africa)
 28 States and 7 Union Territories
 22 Official languages – English is widespread
Ancient Civilization – Young Nation
 Most Heterogeneous and complex
 Very Traditional Yet quite Modern
 Last 20 years GDP CAGR at ~7%
3rd Largest economy of the world in PPP (IMF)
 Sizeable # of Rich, yet average person very poor
 Sci, Tech and Business excel, poor Infrastructure
                  Lifesciences Catalyst           3
Indian LS Industry Snapshot
 3rd Largest Pharma market (by volume)
 LS Market ~ $25B, Healthcare ~ $65B
 Over 20,000 Pharma/BT companies
 Top 20 Companies have presence in Regulated
  markets (US, Canada, Western EU and Japan)
 Top 100 companies are present in 50+ countries
 Globally successful in Generics
 “Every 3rd pill in the world is Made in India”
 Medicine Source of the developing world
 WHO sources over 70% from India
 Largest # of US FDA approved mfg facilities
                Lifesciences Catalyst          4
Indian LS Industry Snapshot…cntd
 Biotech Industry with exploding growth
 Largest pool of Chemists and Biologists
 Abundant specialty health institutions
   14000+ Hospitals, 700,000+ Beds
 Large Pool of Medical professionals
   ~200 Medical Colleges graduating 30,000+ doctors per year
   600,000+ Doctors
  Largest pool of Biosciences Graduates Per
 annum - 3 Million B.S., 700,000 M.S., 15000 Ph Ds
  Indian Regulation – a Super Set of US-FDA
 All Technical & Business work in English
                    Lifesciences Catalyst                       5
Major Centers of LS Business
   City    – Major Companies
 Mumbai – Sun, Lupin,Wockhardt, Glenmark,
             USV, Piramal, Ipca, Most MNCs
 Ahmedabad – Zydus, Intas, Cadila, Torrent
  Hyderabad – Dr. Reddy’s, Aurobindo, Suven,
                Divi’s, Hetero, Shantha, Bharat
  Bengaluru – Biocon, Micro, Strides, GSK,
  New Delhi – Ranbaxy, Panacea, Jubilant
  Chennai – Orchid, Shasun, Tablets India,
  Pune – Bilcare, Serum India, Advinus,

                 Lifesciences Catalyst            6
Major Centers of LS Research
   City    – Research Institutes
  New Delhi – ICPO, IGIB, TERI, ICGEB, IofPath, NIMS,
      NIMR, NIPGR,
  Hyderabad – ICRISAT, CCMB, IICT, CDFD, ILS, LVP
      Eye, NCLAS, NIN, ISB,
  Pune – NCL, Agarkar, Micobial Complex, NARI, NCCS,
      NIV,
 Mumbai – TIFR, BARC, Genetic RC, ICT,
 Ahmedabad – NIPER, NIOH, NSD, IIM,
 Bengaluru – IISc, NCBS, IBioInfoABio,
 Kolkata – Guha CGEB, IICB, NICED,
 Chennai – Biosys BT, CLRI, NIE, TBRC,
 Nagpur – ICAR, CI Cotton R, NEERI, NIIPM, NRCC
 Lucknow – CDRI, CI Med & A Plants, IIToxR, NBRI,
                   Lifesciences Catalyst                 7
Major Intl Deals and Investments
  Wockhardt – Morton Grove, IL
  Sun – Caraco, MI, & Taro Israel
  Dr. Reddy’s – BetaPharm, DowPharma, BASF
  Lupin – Kyowa, Japan
  Piramal – Design Resource Group, MA
  DaiIchi Sankyo – Ranbaxy
  Abbott – Piramal Pharma (Shifting generic mfg)
  Sanofi – Shantha Biotech
  GSK – Large R&D center
  Fresinius Kabi – Large Development Center
  Merck, Estellas, Takeda, Biogen, Amgen, started
                Lifesciences Catalyst          8
Latest Relevant News ….
   Oct 11 – Pharma industry creates 2nd most # of billionaires
   Oct 7 - India US announce Jt Research in BT
   Oct 5 – Takeda in $90 M Discovery deal with Advinus
   Sep 30 – DBT and ABLE roadmap for a $125B by 2025
    Biotech industry from $4B in 2011
   Sep 14 – Piramal to launch own innovative drug in EU
   Sep 12 – Panacea forms JV with US’ Osmotica
   Jul 4 – Serum acquires Dutch firm Bithoven for $100M
   Jul 2 – AstraZeneca & Cellworks to design TB therapies
   Jun 20 – Novozymes & Praj to jtly develop Biofuels
   Jun 4 – Abbott sets Nutri research center with Biocon
   Apr 21 – Merck to set up $150M vaccine lab in Delhi
 Apr 16 – Piramal acquires Imaging R&D portfolio of Bayer
                      Lifesciences Catalyst                9
Indian Firms are looking for

 Partnerships, Investment, Licensing or
 Acquisitions of
 Innovative compounds and technologies
 Co-Development Opportunities
 Novel Drug Delivery Systems
  Manufacturing in IN and the US
 Companies in Regulated markets

              Lifesciences Catalyst       10
Aagami Consulting Services offer

     In-Licensing or Out-Licensing
     Co-Development and Partnerships
     Mergers & Acquisitions
     Investments to and from India
     Finding the Right
       JV partners and/or Distributors
       CRO and CRAMS providers
       Contract Sales/Marketing companies
       Contract Manufacturing companies

                  Lifesciences Catalyst      11
Aagami brings

 Extensive Operational Experience Globally
 Deep Understanding of business and socio-
  cultural differences in ways of working
 Extensive network with top 100 Indian LS
  companies at CXO levels
 Deal experience with Western, Japanese and
  Indian industry
 Dedicated team with focus on Client success

                 Lifesciences Catalyst          12
Business Cultural Differences sample
    Phrases and points in the US vs IN
   •As Soon as Possible : ASAP vs ASAP
   • Tomorrow : Next day vs In near future
   • Will be done : surely be done vs will try best
   • Business focus : Specialist vs Generalist
   • Work driven by : Process vs Ad Hoc
   • Everyday working : MBO vs MBC
   • Business Xaction : Contractual vs Trust base
   • Importance : Transaction vs Relationship
Confidential       Lifesciences Catalyst        13
Sample List of Aagami Clients

       USA                          International
   Dow - MI                    Solvay - Belgium
   Aegis – CA                  Delmar - Canada
   Advangene – IL              SOM Biotech - Spain
   MacuCLEAR – TX              Phosphagenics - Australia
   DesignMedix – OR            NanoSensing - Brazil
   Unitech Pharma – MI         Affitech - Denmark
   Loyola U Chicago – IL       Ilsan Ilvac - Turkey
   MW Univ. – IL, AZ           Pieris - Germany
   PLx - TX                    Toppan – Japan

                   Lifesciences Catalyst                 14
Our Approach
 Prepare ‘Elevator Pitch’ on client technology and/or company
  customized to Specific business culture for e.g. India, Japan
 Identify Relevant Companies from our Database and resources
 Broadcast EP to Relevant Companies by email
 Follow-up with phone calls and emails with all
 Coordinate CDAs with interested Companies, and supply further
  info thru emails and conference calls
 Organize a road show to India along with client representative/s
 Take appointments with right executives in interested companies
 Coordinate the logistics of the road show (v imp)
 Support in structuring and negotiations for finalizing the deal(s)

                       Lifesciences Catalyst                     15
Realizing Possibilities with

      Aagami, Inc.
      2020 Calamos Ct, Suite 209
      Naperville, IL 60564
      Phone: (630) 799-1572
      dinesh@aagami.net
      www.aagami.net



               Lifesciences Catalyst   16

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MRUN India Presentation by Aagami

  • 1. Connecting Midwest High Tech Startups With India MRUN Conf - Oct 12, 2012 Dinesh Jain, Founder CEO Aagami, Inc. …LifeSciences Catalyst
  • 2. Topics covered  India – an Introduction  IN Lifesciences Industry snapshot  Major centers of Lifesciences in India  Major Deals and Investments showing  India as a Market Place  India as a Resource Place  What Indian LS firms are looking for  How Aagami Supports Companies Lifesciences Catalyst 2
  • 3. India – a Brief Introduction (V-IMP) Nation of 1.22 Billion people (~EU+Africa)  28 States and 7 Union Territories  22 Official languages – English is widespread Ancient Civilization – Young Nation  Most Heterogeneous and complex  Very Traditional Yet quite Modern  Last 20 years GDP CAGR at ~7% 3rd Largest economy of the world in PPP (IMF)  Sizeable # of Rich, yet average person very poor  Sci, Tech and Business excel, poor Infrastructure Lifesciences Catalyst 3
  • 4. Indian LS Industry Snapshot  3rd Largest Pharma market (by volume)  LS Market ~ $25B, Healthcare ~ $65B  Over 20,000 Pharma/BT companies  Top 20 Companies have presence in Regulated markets (US, Canada, Western EU and Japan)  Top 100 companies are present in 50+ countries  Globally successful in Generics  “Every 3rd pill in the world is Made in India”  Medicine Source of the developing world  WHO sources over 70% from India  Largest # of US FDA approved mfg facilities Lifesciences Catalyst 4
  • 5. Indian LS Industry Snapshot…cntd Biotech Industry with exploding growth Largest pool of Chemists and Biologists Abundant specialty health institutions  14000+ Hospitals, 700,000+ Beds Large Pool of Medical professionals  ~200 Medical Colleges graduating 30,000+ doctors per year  600,000+ Doctors  Largest pool of Biosciences Graduates Per annum - 3 Million B.S., 700,000 M.S., 15000 Ph Ds  Indian Regulation – a Super Set of US-FDA All Technical & Business work in English Lifesciences Catalyst 5
  • 6. Major Centers of LS Business City – Major Companies Mumbai – Sun, Lupin,Wockhardt, Glenmark, USV, Piramal, Ipca, Most MNCs Ahmedabad – Zydus, Intas, Cadila, Torrent  Hyderabad – Dr. Reddy’s, Aurobindo, Suven, Divi’s, Hetero, Shantha, Bharat  Bengaluru – Biocon, Micro, Strides, GSK,  New Delhi – Ranbaxy, Panacea, Jubilant  Chennai – Orchid, Shasun, Tablets India,  Pune – Bilcare, Serum India, Advinus, Lifesciences Catalyst 6
  • 7. Major Centers of LS Research City – Research Institutes  New Delhi – ICPO, IGIB, TERI, ICGEB, IofPath, NIMS, NIMR, NIPGR,  Hyderabad – ICRISAT, CCMB, IICT, CDFD, ILS, LVP Eye, NCLAS, NIN, ISB,  Pune – NCL, Agarkar, Micobial Complex, NARI, NCCS, NIV, Mumbai – TIFR, BARC, Genetic RC, ICT, Ahmedabad – NIPER, NIOH, NSD, IIM, Bengaluru – IISc, NCBS, IBioInfoABio, Kolkata – Guha CGEB, IICB, NICED, Chennai – Biosys BT, CLRI, NIE, TBRC, Nagpur – ICAR, CI Cotton R, NEERI, NIIPM, NRCC Lucknow – CDRI, CI Med & A Plants, IIToxR, NBRI, Lifesciences Catalyst 7
  • 8. Major Intl Deals and Investments  Wockhardt – Morton Grove, IL  Sun – Caraco, MI, & Taro Israel  Dr. Reddy’s – BetaPharm, DowPharma, BASF  Lupin – Kyowa, Japan  Piramal – Design Resource Group, MA  DaiIchi Sankyo – Ranbaxy  Abbott – Piramal Pharma (Shifting generic mfg)  Sanofi – Shantha Biotech  GSK – Large R&D center  Fresinius Kabi – Large Development Center  Merck, Estellas, Takeda, Biogen, Amgen, started Lifesciences Catalyst 8
  • 9. Latest Relevant News ….  Oct 11 – Pharma industry creates 2nd most # of billionaires  Oct 7 - India US announce Jt Research in BT  Oct 5 – Takeda in $90 M Discovery deal with Advinus  Sep 30 – DBT and ABLE roadmap for a $125B by 2025 Biotech industry from $4B in 2011  Sep 14 – Piramal to launch own innovative drug in EU  Sep 12 – Panacea forms JV with US’ Osmotica  Jul 4 – Serum acquires Dutch firm Bithoven for $100M  Jul 2 – AstraZeneca & Cellworks to design TB therapies  Jun 20 – Novozymes & Praj to jtly develop Biofuels  Jun 4 – Abbott sets Nutri research center with Biocon  Apr 21 – Merck to set up $150M vaccine lab in Delhi  Apr 16 – Piramal acquires Imaging R&D portfolio of Bayer Lifesciences Catalyst 9
  • 10. Indian Firms are looking for Partnerships, Investment, Licensing or Acquisitions of Innovative compounds and technologies Co-Development Opportunities Novel Drug Delivery Systems  Manufacturing in IN and the US Companies in Regulated markets Lifesciences Catalyst 10
  • 11. Aagami Consulting Services offer  In-Licensing or Out-Licensing  Co-Development and Partnerships  Mergers & Acquisitions  Investments to and from India  Finding the Right  JV partners and/or Distributors  CRO and CRAMS providers  Contract Sales/Marketing companies  Contract Manufacturing companies Lifesciences Catalyst 11
  • 12. Aagami brings Extensive Operational Experience Globally Deep Understanding of business and socio- cultural differences in ways of working Extensive network with top 100 Indian LS companies at CXO levels Deal experience with Western, Japanese and Indian industry Dedicated team with focus on Client success Lifesciences Catalyst 12
  • 13. Business Cultural Differences sample Phrases and points in the US vs IN •As Soon as Possible : ASAP vs ASAP • Tomorrow : Next day vs In near future • Will be done : surely be done vs will try best • Business focus : Specialist vs Generalist • Work driven by : Process vs Ad Hoc • Everyday working : MBO vs MBC • Business Xaction : Contractual vs Trust base • Importance : Transaction vs Relationship Confidential Lifesciences Catalyst 13
  • 14. Sample List of Aagami Clients USA International  Dow - MI  Solvay - Belgium  Aegis – CA  Delmar - Canada  Advangene – IL  SOM Biotech - Spain  MacuCLEAR – TX  Phosphagenics - Australia  DesignMedix – OR  NanoSensing - Brazil  Unitech Pharma – MI  Affitech - Denmark  Loyola U Chicago – IL  Ilsan Ilvac - Turkey  MW Univ. – IL, AZ  Pieris - Germany  PLx - TX  Toppan – Japan Lifesciences Catalyst 14
  • 15. Our Approach  Prepare ‘Elevator Pitch’ on client technology and/or company customized to Specific business culture for e.g. India, Japan  Identify Relevant Companies from our Database and resources  Broadcast EP to Relevant Companies by email  Follow-up with phone calls and emails with all  Coordinate CDAs with interested Companies, and supply further info thru emails and conference calls  Organize a road show to India along with client representative/s  Take appointments with right executives in interested companies  Coordinate the logistics of the road show (v imp)  Support in structuring and negotiations for finalizing the deal(s) Lifesciences Catalyst 15
  • 16. Realizing Possibilities with Aagami, Inc. 2020 Calamos Ct, Suite 209 Naperville, IL 60564 Phone: (630) 799-1572 dinesh@aagami.net www.aagami.net Lifesciences Catalyst 16