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By: Abi Benedict
The Key Players
                
 Issue
  • Lactase Deficiency
 Disease
  • Lactose Intolerance
What is lactose
                     intolerance?
                          
 Lactose intolerance is the inability to
  digest lactose, a sugar found in milk
  and milk products When the body
  consumes any milk or milk based
  products, lactose, the sugar found in
  milk products is also consumed.
 In order to break down the sugar into
  glucose and galactose that can be
  absorbed into the bloodstream, the
  body uses the enzyme named lactase.
 The body’s inability to process milk
  and milk products is called lactose
  intolerance and is caused by the
  deficiency of the lactase enzyme.
Enzymes
                               
 The purpose of an enzyme in a cell is
  to allow the cell to carry out chemical
  reactions quickly.
 These reactions allow the cell to
  constuct things or take things apart
  when needed. This is how a cell grows
  and reproduces.
 a cell is really a little bag full of
  reactions that are made possible by
  enzymes.
 http://www.youtube.com/watch?v=JiFy-
  2hzJlw&feature=related
Hydrolysis
                                 
Lactase hydrolysis cuts by
adding water to the sugar
lactose into two simple
sugars, glucose and
galactose. Both the initial
and final solutions are
colourless.
Lactase Deficiency

     when the body begins
     to produce less lactase



     results from injury to
     the small intestine
     that occurs with
     severe diarrheal
     illness, celiac disease,,
     or chemotherapy.
     is a genetic disorder
     which prevents
     enzymatic production
     of lactase.
What is Lactase?
                           
 Lactase is a form of enzyme
  which is present in the
  human's small intestine.
 It is responsible for the
  digestion and break down of
  lactose (or milk sugar) in
  milk products.
SYMPTOMS
             •   abdominal pain
            • abdominal bloating
                    • gas
                 • diarrhea
                  • nausea
http://www.youtube.com/watch?v=8V81uwYDa0Q
Calcium Chart (Intake)
         
How does lactose intolerance
     effect your body?
                                    
 Lactose intolerance can give
  you a high chance of
  developing osteoporosis.
 Osteoporosis is a condition
  characterized by a decrease in
  the density of a bone,
  decreasing its strength and
  resulting in fragile bones.
 Osteoporosis is due to lack of
  calcium, which dairy products
  can give you, which lactose
  intolerant people can not gain.
Tests
                          
 Endoscopy
Endoscopy is a way of looking
inside the body using a
flexible tube that has a small
camera on the end of it. This
instrument is called an
endoscope.
Tests
 Lactose- Hydrogen Breath
                          
    Test
•   A breath sample will be
    collected and tested for the
    presence of hydrogen.
•   To obtain the sample, you
    will be asked to blow up a
    balloon-type bag.
•   Normally, very little
    hydrogen is found in the
    breath.
•   Increased hydrogen breath
    levels indicate improper
    digestion.
Tests
 Lactose Tolerance Test
                                      
• Measures how well the body breaks down milk sugar in the intestines. The
   patient must not eat or drink for 8 to 12 hours before the test. After this, a blood
   sample is taken in order to measure the amount of sugar in the blood. A
   solution containing milk, sugar and some lemon is then drunk by the patient. If
   they are able to break down milk sugar properly in the intestines, the level of
   sugar in the blood will rise within an hour of drinking the solution. Then
   another blood test would be taking place. If the level of blood sugar does not
   rise this may mean lactose is not split into galactose and glucose.
 Stool pH
A fecal pH test is one where a induvisual of feces is tested for acidity in order to
diagnose a medical condition. Human feces is normally alkaline. An acidic stool
can indicate a digestive problem such as lactose intolerance.
Treatment/Technologies
 Lactose Avoidance
                    
  • The most effective treatment is to avoid foods and
    medications that contain lactose, primarily milk and
    milk products.
 Calcium Supplementation
  • Physicians recommend that you take
    supplemental calcium. Which include pills, or
    different types of juice.
Treatment/Technologies
          
 Lactase Enzyme
  Supplementation
  •    You can take lactase
      enzyme supplements to
      prevent symptoms when
      eating/drinking lactose-
      containing dairy
      products.
  •   Lactase drops may be
      dropped into regular
      milk 24 hours before
      drinking to reduce
      lactose levels.
Technology/Something
         New
          
 Something that they
  can develop is an app
  for Iphones or
  blackberries, to see
  what percentage of
  dairy is in a product.
 Also a new technology
  they should develop is
  finding if a child is
  lactose intolerance
  before the child is born.
News Articles
               
 http://www.usatoday.com/tech/science/2009-08-
  30-lactose-intolerance_N.htm
 http://news.bbc.co.uk/2/hi/6397001.stm
 http://latino.foxnews.com/latino/health/2012/01/
  20/think-are-lactose-intolerant-might-want-to-think-
  again/
 http://www.gastrojournal.org/article/S0016-
  5085(02)00013-
  6/abstract?referrer=http%3A%2F%2Fscholar.google.
  ca%2Fscholar%3Fhl%3Den
Something to think about. . .
                        
 Do you think its safe to take pills that help you
  digest dairy? What if something goes wrong? Is there
  a way to fix that?
 Do you think soya milk is safe to drink when you are
  lactose intolerant?
 Do you think that lactose intolerance can run in
  genes?

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Ms. Shaikh Biology Unit Task

  • 2. The Key Players   Issue • Lactase Deficiency  Disease • Lactose Intolerance
  • 3. What is lactose intolerance?   Lactose intolerance is the inability to digest lactose, a sugar found in milk and milk products When the body consumes any milk or milk based products, lactose, the sugar found in milk products is also consumed.  In order to break down the sugar into glucose and galactose that can be absorbed into the bloodstream, the body uses the enzyme named lactase.  The body’s inability to process milk and milk products is called lactose intolerance and is caused by the deficiency of the lactase enzyme.
  • 4. Enzymes   The purpose of an enzyme in a cell is to allow the cell to carry out chemical reactions quickly.  These reactions allow the cell to constuct things or take things apart when needed. This is how a cell grows and reproduces.  a cell is really a little bag full of reactions that are made possible by enzymes.  http://www.youtube.com/watch?v=JiFy- 2hzJlw&feature=related
  • 5. Hydrolysis  Lactase hydrolysis cuts by adding water to the sugar lactose into two simple sugars, glucose and galactose. Both the initial and final solutions are colourless.
  • 6. Lactase Deficiency when the body begins to produce less lactase results from injury to the small intestine that occurs with severe diarrheal illness, celiac disease,, or chemotherapy. is a genetic disorder which prevents enzymatic production of lactase.
  • 7. What is Lactase?   Lactase is a form of enzyme which is present in the human's small intestine.  It is responsible for the digestion and break down of lactose (or milk sugar) in milk products.
  • 8. SYMPTOMS • abdominal pain • abdominal bloating • gas • diarrhea • nausea http://www.youtube.com/watch?v=8V81uwYDa0Q
  • 10. How does lactose intolerance effect your body?   Lactose intolerance can give you a high chance of developing osteoporosis.  Osteoporosis is a condition characterized by a decrease in the density of a bone, decreasing its strength and resulting in fragile bones.  Osteoporosis is due to lack of calcium, which dairy products can give you, which lactose intolerant people can not gain.
  • 11. Tests   Endoscopy Endoscopy is a way of looking inside the body using a flexible tube that has a small camera on the end of it. This instrument is called an endoscope.
  • 12. Tests  Lactose- Hydrogen Breath  Test • A breath sample will be collected and tested for the presence of hydrogen. • To obtain the sample, you will be asked to blow up a balloon-type bag. • Normally, very little hydrogen is found in the breath. • Increased hydrogen breath levels indicate improper digestion.
  • 13. Tests  Lactose Tolerance Test  • Measures how well the body breaks down milk sugar in the intestines. The patient must not eat or drink for 8 to 12 hours before the test. After this, a blood sample is taken in order to measure the amount of sugar in the blood. A solution containing milk, sugar and some lemon is then drunk by the patient. If they are able to break down milk sugar properly in the intestines, the level of sugar in the blood will rise within an hour of drinking the solution. Then another blood test would be taking place. If the level of blood sugar does not rise this may mean lactose is not split into galactose and glucose.  Stool pH A fecal pH test is one where a induvisual of feces is tested for acidity in order to diagnose a medical condition. Human feces is normally alkaline. An acidic stool can indicate a digestive problem such as lactose intolerance.
  • 14. Treatment/Technologies  Lactose Avoidance  • The most effective treatment is to avoid foods and medications that contain lactose, primarily milk and milk products.  Calcium Supplementation • Physicians recommend that you take supplemental calcium. Which include pills, or different types of juice.
  • 15. Treatment/Technologies   Lactase Enzyme Supplementation • You can take lactase enzyme supplements to prevent symptoms when eating/drinking lactose- containing dairy products. • Lactase drops may be dropped into regular milk 24 hours before drinking to reduce lactose levels.
  • 16. Technology/Something New   Something that they can develop is an app for Iphones or blackberries, to see what percentage of dairy is in a product.  Also a new technology they should develop is finding if a child is lactose intolerance before the child is born.
  • 17. News Articles   http://www.usatoday.com/tech/science/2009-08- 30-lactose-intolerance_N.htm  http://news.bbc.co.uk/2/hi/6397001.stm  http://latino.foxnews.com/latino/health/2012/01/ 20/think-are-lactose-intolerant-might-want-to-think- again/  http://www.gastrojournal.org/article/S0016- 5085(02)00013- 6/abstract?referrer=http%3A%2F%2Fscholar.google. ca%2Fscholar%3Fhl%3Den
  • 18. Something to think about. . .   Do you think its safe to take pills that help you digest dairy? What if something goes wrong? Is there a way to fix that?  Do you think soya milk is safe to drink when you are lactose intolerant?  Do you think that lactose intolerance can run in genes?