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Chapter 12: DNA and RNA with Steve and Joe

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DNA is a double helical structure that transfers the genetic information from one generation to another. it consists of two strands with the four nucleotide basis .The four nucleotides contains adenine, cytosine, guanine, thymine .These four nuclic basis are such arranged and coiled with the help of hydrogen bonds and forms the helical structure of DNA. In RNA the thymine is replaced with uracil. Here you will learn the replication ,transcription and translation process in DNA.

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Ribonucleic acid (RNA) is a polymeric molecule essential in various biological roles in coding, decoding, regulation, and expression of genes. RNA and DNA are nucleic acids, and, along with proteins and carbohydrates, constitute the four major macromolecules essential for all known forms of life. Like DNA, RNA is assembled as a chain of nucleotides, but unlike DNA it is more often found in nature as a single-strand folded onto itself, rather than a paired double-strand.

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Chapter 8: Microbial Genetics * Plasmids Exist in Cells Separate from Chromosomes Big Picture: Genetics The science of heredity Central dogma of molecular biology Mutations Gene expression controlled by operons Alteration of bacterial genes and/or gene expression Cause of disease Prevent disease treatment Manipulated for human benefit Big Picture: Genetics Structure and Function of the Genetic Material Learning Objectives 8-1 Define genetics, genome, chromosome, gene, genetic code, genotype, phenotype, and genomics. 8-2 Describe how DNA serves as genetic information. 8-3 Describe the process of DNA replication. 8-4 Describe protein synthesis, including transcription, RNA processing, and translation. 8-5 Compare protein synthesis in prokaryotes and eukaryotes. Structure and Function of the Genetic Material Genetics: the study of genes, how they carry information, how information is expressed, and how genes are replicated Chromosomes: structures containing DNA that physically carry hereditary information; the chromosomes contain genes Genes: segments of DNA that encode functional products, usually proteins Genome: all the genetic information in a cell Structure and Function of the Genetic Material The genetic code is a set of rules that determines how a nucleotide sequence is converted to an amino acid sequence of a proteinCentral dogma: Genotype and Phenotype Genotype: the genetic makeup of an organism Phenotype: expression of the genes DNA and Chromosomes Bacteria usually have a single circular chromosome made of DNA and associated proteins Short tandem repeats (STRs): repeating sequences of noncoding DNA Figure 8.1 A Prokaryotic Chromosome Chromosome The Flow of Genetic Information Vertical gene transfer: flow of genetic information from one generation to the next Horizontal gene transfer: flow of genetic information between individuals of the SAME generation (see the middle portion of the next slide!) Figure 8.2 The Flow of Genetic Information Parent cell DNA Genetic information is used within a cell to produce the proteins needed for the cell to function. Genetic information can be transferred horizontally between cells of the same generation. Genetic information can be transferred vertically to the next generation of cells. New combinations of genes Translation Cell metabolizes and grows Recombinant cell Offspring cells Transcription DNA Replication DNA forms a double helix “Backbone” consists of deoxyribose-phosphate Two strands of nucleotides are held together by hydrogen bonds between A-T and C-G Strands are antiparallel Order of the nitrogen-containing bases forms the genetic instructions of the organism DNA Replication One strand serves as a template for the production of a second strand Topoisomerase and gyrase relax the strands Helicase separates the strands A replication fork is created DNA Replication DNA poly ...

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