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Life Under Sess:
Welcome To e 21st Century




  An Inoducon To Medical Ecology
Total biomass of the earth = 1,840 x 109 tonnes

Total biomass of all animals = 0.2 x 109 tonnes
                           = 200 x 106 tonnes
Total biomass of humans
Ecosystem Services*




* from: Living In The Environment Thompson Brooks/Cole Pubs. 2004
A 6th Mass Extinction?
Some Good News Regarding Extinction:
     Smallpox - eliminated
               (probably)


     Polio - nearly gone



     Yaws - almost eliminated



     Onchocerciasis - on its way out
The Bad News Is We May Be Next!


   Billions          % Urban




                      1973
                      1973
*
               Some Bad News:

        Since 1973 over 50 new
infectious disease entities have emerged
         onto the human scene




     * ProMed reporter-at-large
More Bad News:
Most vector-borne diseases are on the rise
About 25% of all drugs currently on
the market come from natural sources
Chopping Down The Tree Of Life




                      27,000 species/yr
                       1950-present
How many new drugs have been lost
 due to extinction of species of plants and
animals that we had no idea even existed?
Why we should care
A 21st Century Dilemma:
Microbial Drug Resistance*



 *See: http://www.fda.gov/cvm/antimicrobial/022200slides/White/tsld004.htm
Top Ten Drug-resistant Microbes
Microbe                      Disease                    Resistance
Enterobacteriaceae           bacteremia, pneumonia      aminoglycosides
                             wound infections           β-lactams
                                                        chloramphenicol
                                                        trimethoprim
                                                        FQs
Enterococcus                 bacteremia                 aminoglycosides
                             wound infections           β-lactams
                                                        erythromycin
                                                        glycopeptides
Haemophilus influenzae        meningitis, otitis media   β-lactams
                             pneumonia                  tetracycline
                                                        chloramphenicol
                                                        trimethaprim

Mycobacterium tuberculosis   tuberculosis               aminoglycosides
                                                        ethambutol
                                                        isoniazid
                                                        rifampin

Nisseria gonorrhoea          gonorrhea                  β-lactams
                                                        tetracylcine
                                                        FQs
Microbe                    Disease                 Resistance

Plasmodium falciparum      malaria                 chloroquine

Pseudomonas aerogenosa     bacteremia, pneumonia   aminoglycosides
                           UTIs                    β-lactams
                                                   tetracycline
                                                   TMX

Shigella dysenteriae       severe dysentery        ampicillin
                                                   chloramphenicol
                                                   tetracycline
                                                   TMX

Staphylococcus aureus      bacteremia, pneumonia   chloramphenicol
                           wound infections        macrolides
                                                   trimethoprim
                                                   FQs
                                                   β-lactams
                                                   tetracycline
                                                   glycopeptides?

Streptococcus pneumoniae   meningitis, pneumonia   aminoglycosides
                                                   chloramphenicol
                                                   macrolides
                                                   penicillin
Malaria
300 million infections/year
3 million deaths/year, mostly in Africa

Drugs - Most strains of Plasmodium falciparum are
        resistant to chloroquine and its derivatives.




Best Control Method: Eliminate breeding sites for vector
                     species of mosquitoes.
Examples:
       Ancient Rome - Construct city of Ostia
       South Eastern USA drained swamps, creating new farmland.
The Linkages Between
Environmental Degradation
 And Infectious Diseases
Fragmentation of Ecosystems
Fragmentation of Ecosystems


        Agriculture
         Agriculture
         Settlement
         Settlement
          Mining
           Mining
      Industrialization
      Industrialization
        Civil unrest
        Civil unrest
            War
            War
Sources Of Pollution
            Non-point Sources:
                 1. Agricultural*
                 2. Residential
            Point Sources:
                 1. Industrial
                 2. Residential

*Largest world-wide source - soil erosion, pesticides, fertilizers, herbicides, heavy metals,
                       animal and human waste, etc.
Q: Who allows this?

A: The EPA:
Agricultural runoff is exempt from
The Clean Water Act




See: http://www.epa.gov/region5/water/cwa.htm
Cryptosporidium parvum




Reservoir host
Access to safe drinking water is everyone’s right
Yet……………..
Many Tropical Infectious Diseases Are
  Transmitted At The Agricultural
             Interface
             Malaria
             Hookworm
             Ascaris
             Trichuris
             Schistosomiasis
             Filariasis
             Nipha
Geohelminths (hookworm, ascaris, trichuris)
Eliminate feces as an environmental contaminant and you effectively
control the spread all parasitic diseases spread by fecal-oral route.

Two approaches, two different outcomes:

United States :
The birth of the outhouse. This single architectural
wonder controlled all fecally-transmitted infections:
viruses, bacteria, protozoa, and helminths.

Southeast Asia and China:
Ferment feces before using
it as fertilizer on crops: eliminated hookworm.
In 2050 Population Stabilizes At 9.3 billion*




              *
Population Growth and Poverty
Problem:

How to feed the next 2.8 billion people
without incurring more environmental
damage due to traditional agricultural
practices
Land Use And Agriculture
     Rondonia, Brazil
                           1975
                           1975




  1986
  1986                     1992
                           1992
Conclusion of Science article
Don’t just sit there,
do something!
A Possible Solution:
The Vertical Farm
Vibrant,
 successful cities
 are not only
 possible but
 necessary for the
 health of society
 and our planet.
 Urban Ecology
 plans and designs
 cities that sustain
 the people,
 natural
 resources, and
 economy
 necessary for
 everyone to
 thrive.




http://www.urbanecology.org/
Advantages Of Vertical Farming
•   Year-round crop production
•   No weather related crop failures due to droughts, floods
•   Eliminates agricultural runoff
•   Converts black water to potable water
•   Greatly reduces the incidence of many infectious diseases
•   Adds energy back to the grid via methane generation
•   Dramatically reduces fossil fuel use (no tractors, plows, etc.)
•   Converts abandoned urban properties into food production
•   Sustainability for urban centers
•   Creates new employment opportunities
•   Returns farm land to nature, restoring ecosystem services
•   Reduces the incidence of armed conflict over natural
       resources, such as water and land for agriculture
Advantages Of Vertical Farming
Adds energy back to the grid via methane generation

           What A Difference A Day Makes




       August 14th                August 15th
Advantages Of Vertical Farming
  Returns farm land to nature,
  restoring ecosystem services
A Vertical Farm*




      * not exactly what I had in mind
Vertical New York City




                Photo: NASA
Virtual Vertical Farm*




*www.verticalfarm.com
Medical Ecology
 Class of 2003*
  Kristin Anderson
  Nicola Areshenko
     Alan Brown
  Jennifer Buskey
  Amanda Colligan
  Marisa Dahlman
 Catherine Dell’Orto
  Catherine Tuglus

*Steven Chen- technical advisor
How It Could Work
Sustainability through re-cycling
Bioremediation
 Re-gain “lost” water
Energy Considerations
 Capture all energy in black water
Methane Digester
 No new technology needed
Original Design by Andrew Kranis, Columbia University School of Architecture 2003
A lunar colony
Schematic for advanced life-support system
Or a colony on Mars
Components for a Mars colony
The Dawn Of
A New Beginning
     (perhaps)
So, What’s For Dinner?
Anything you want
Any Time You Want It
Any Where In The World
Or In The Universe

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Vf Life Under Stress

  • 1. Life Under Sess: Welcome To e 21st Century An Inoducon To Medical Ecology
  • 2.
  • 3. Total biomass of the earth = 1,840 x 109 tonnes Total biomass of all animals = 0.2 x 109 tonnes = 200 x 106 tonnes Total biomass of humans
  • 4. Ecosystem Services* * from: Living In The Environment Thompson Brooks/Cole Pubs. 2004
  • 5.
  • 6.
  • 7.
  • 8. A 6th Mass Extinction?
  • 9.
  • 10. Some Good News Regarding Extinction: Smallpox - eliminated (probably) Polio - nearly gone Yaws - almost eliminated Onchocerciasis - on its way out
  • 11. The Bad News Is We May Be Next! Billions % Urban 1973 1973
  • 12. * Some Bad News: Since 1973 over 50 new infectious disease entities have emerged onto the human scene * ProMed reporter-at-large
  • 13.
  • 14. More Bad News: Most vector-borne diseases are on the rise
  • 15. About 25% of all drugs currently on the market come from natural sources
  • 16. Chopping Down The Tree Of Life 27,000 species/yr 1950-present
  • 17. How many new drugs have been lost due to extinction of species of plants and animals that we had no idea even existed?
  • 19. A 21st Century Dilemma: Microbial Drug Resistance* *See: http://www.fda.gov/cvm/antimicrobial/022200slides/White/tsld004.htm
  • 20. Top Ten Drug-resistant Microbes Microbe Disease Resistance Enterobacteriaceae bacteremia, pneumonia aminoglycosides wound infections β-lactams chloramphenicol trimethoprim FQs Enterococcus bacteremia aminoglycosides wound infections β-lactams erythromycin glycopeptides Haemophilus influenzae meningitis, otitis media β-lactams pneumonia tetracycline chloramphenicol trimethaprim Mycobacterium tuberculosis tuberculosis aminoglycosides ethambutol isoniazid rifampin Nisseria gonorrhoea gonorrhea β-lactams tetracylcine FQs
  • 21. Microbe Disease Resistance Plasmodium falciparum malaria chloroquine Pseudomonas aerogenosa bacteremia, pneumonia aminoglycosides UTIs β-lactams tetracycline TMX Shigella dysenteriae severe dysentery ampicillin chloramphenicol tetracycline TMX Staphylococcus aureus bacteremia, pneumonia chloramphenicol wound infections macrolides trimethoprim FQs β-lactams tetracycline glycopeptides? Streptococcus pneumoniae meningitis, pneumonia aminoglycosides chloramphenicol macrolides penicillin
  • 22. Malaria 300 million infections/year 3 million deaths/year, mostly in Africa Drugs - Most strains of Plasmodium falciparum are resistant to chloroquine and its derivatives. Best Control Method: Eliminate breeding sites for vector species of mosquitoes. Examples: Ancient Rome - Construct city of Ostia South Eastern USA drained swamps, creating new farmland.
  • 23. The Linkages Between Environmental Degradation And Infectious Diseases
  • 24. Fragmentation of Ecosystems Fragmentation of Ecosystems Agriculture Agriculture Settlement Settlement Mining Mining Industrialization Industrialization Civil unrest Civil unrest War War
  • 25. Sources Of Pollution Non-point Sources: 1. Agricultural* 2. Residential Point Sources: 1. Industrial 2. Residential *Largest world-wide source - soil erosion, pesticides, fertilizers, herbicides, heavy metals, animal and human waste, etc.
  • 26. Q: Who allows this? A: The EPA: Agricultural runoff is exempt from The Clean Water Act See: http://www.epa.gov/region5/water/cwa.htm
  • 28. Access to safe drinking water is everyone’s right
  • 30.
  • 31. Many Tropical Infectious Diseases Are Transmitted At The Agricultural Interface Malaria Hookworm Ascaris Trichuris Schistosomiasis Filariasis Nipha
  • 32.
  • 33. Geohelminths (hookworm, ascaris, trichuris) Eliminate feces as an environmental contaminant and you effectively control the spread all parasitic diseases spread by fecal-oral route. Two approaches, two different outcomes: United States : The birth of the outhouse. This single architectural wonder controlled all fecally-transmitted infections: viruses, bacteria, protozoa, and helminths. Southeast Asia and China: Ferment feces before using it as fertilizer on crops: eliminated hookworm.
  • 34. In 2050 Population Stabilizes At 9.3 billion* *
  • 36. Problem: How to feed the next 2.8 billion people without incurring more environmental damage due to traditional agricultural practices
  • 37.
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  • 40. Land Use And Agriculture Rondonia, Brazil 1975 1975 1986 1986 1992 1992
  • 42. Don’t just sit there, do something!
  • 43. A Possible Solution: The Vertical Farm
  • 44. Vibrant, successful cities are not only possible but necessary for the health of society and our planet. Urban Ecology plans and designs cities that sustain the people, natural resources, and economy necessary for everyone to thrive. http://www.urbanecology.org/
  • 45. Advantages Of Vertical Farming • Year-round crop production • No weather related crop failures due to droughts, floods • Eliminates agricultural runoff • Converts black water to potable water • Greatly reduces the incidence of many infectious diseases • Adds energy back to the grid via methane generation • Dramatically reduces fossil fuel use (no tractors, plows, etc.) • Converts abandoned urban properties into food production • Sustainability for urban centers • Creates new employment opportunities • Returns farm land to nature, restoring ecosystem services • Reduces the incidence of armed conflict over natural resources, such as water and land for agriculture
  • 46. Advantages Of Vertical Farming Adds energy back to the grid via methane generation What A Difference A Day Makes August 14th August 15th
  • 47. Advantages Of Vertical Farming Returns farm land to nature, restoring ecosystem services
  • 48. A Vertical Farm* * not exactly what I had in mind
  • 49. Vertical New York City Photo: NASA
  • 51. Medical Ecology Class of 2003* Kristin Anderson Nicola Areshenko Alan Brown Jennifer Buskey Amanda Colligan Marisa Dahlman Catherine Dell’Orto Catherine Tuglus *Steven Chen- technical advisor
  • 52. How It Could Work Sustainability through re-cycling
  • 54. Energy Considerations Capture all energy in black water
  • 55. Methane Digester No new technology needed
  • 56. Original Design by Andrew Kranis, Columbia University School of Architecture 2003
  • 57.
  • 59. Schematic for advanced life-support system
  • 60. Or a colony on Mars
  • 61. Components for a Mars colony
  • 62.
  • 63. The Dawn Of A New Beginning (perhaps)
  • 64. So, What’s For Dinner?
  • 66. Any Time You Want It
  • 67. Any Where In The World
  • 68. Or In The Universe