cancer drug side effects is a very important topic for pg entrance....so all important points and mcqs with images have been given here....do make use of it

1. DRUG IMPORTANT SIDE EFFECTS
ALKYLATING AGENTS Secondary Leukemias
Busulfan Lung fibrosis
Bleomycin Lung fibrosis
Cyclophosphomide Hemorrhagic Cystitis
Nitrosureas (Carmustine) Persistent Neutropenia
Cisplatin Most emitogenic
Nephrotoxic, Ototoxic
Carboplatin Maximum Bone marrow
suppression
Methotrexate Megaloblastic
Anemia/Hepatotoxic
6-Mercaptopurine / 6-
Thioguanine
Hepatotoxic
5-FU Hand and foot disease

2. Capecitabine Hand and foot disease
Cytarabine
(Arabinofuranisyl Cytidine)
Cerebellar Ataxia
Vincristine SIADH, Peripheral
Neuropathy
Vinblastine Bone marrow suppression
Paclitaxel Allergy, Peripheral
Neuropathy
Etoposide Secondary Leukemias
Anthracyclines
(Doxorubocin,
Daunorubocin)
Cardiotoxic
L-Asparaginase Allergy
Pancreatitis
Hypercoagulable Sx
Imatinib Rash

3. Tacrolimus Nephrotoxic, Neurotoxic,
Alopecia, Precipitates DM
But not Ototoxic
Cyclosporine Nephrotoxic, Increase
Infection Risk, Hepatotoxic
Thalidomide S –Sedation
Po- Phocomelia, Peripheral
neuropathy
R – Rash
T – Thrombosis
Channel – Constipation
Mycophenolate and
Azathioprine
Bone marrow suppression
Leflunomide Liver and lung injury