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- DR.AKIF A.B
1) A case of poisoning was brought to the casualty,
a gastric lavage was done, and the lavage turned black
when it was hea...
Ans. B Celfos
Aluminium phosphide-
AgNo3 filter paper is turned black by fumes of suspected gastric
aspirate containing Ph...
-Aluminium phosphide
-3gm of celphos liberates 1 gm of phosphene which inhibits cytochrome
oxidase and causes respiratory ...
2.Q. Haemodialysis is mandatory in which poisoning?
A Copper sulphate poisoning
B Ethanol poisoning
C Amphetamine poisonin...
Ans. B Ethanol poisoning
B = Barbiturates
L = Lithium
A = Alcohol
S = Salicylates
T = Thiophylline/Thiocyanate
HEMODIALYSIS IS C.I
in POISONS
erosene
enzodiaepine
hloroquine/CuSO4
eroin
3.Q. Widmark’s formula is used for measurement of blood levels of:
A Benzodiazepines
B Barbiturates
C Alcohol
D Tranquiliz...
Ans. ALCOHOL
WIDMARK FORMULA
A = P C R
Wt. of
alcohol Body wt.
Conc.of
alcohol
Constant, Males=0.6
Females= 0.5
-Best method for alcohol estimation = Gas chromatography
- Amitabh = Alcohol dehydrogenase
-K = Kozelka test
-B = Breath a...
4.Q. Which of the following beverages contains the
maximum percentage of alcohol:
A Whisky
B Brandy
C Wine
D Rum
Ans. D Rum
Rum = 50-60% alcohol.
Whisky, Gin, Brandy = 40-45%.
Port, Sherry = 20%.
Wine = 10-15%.
Beers = 4-8%.
5.Q. In carbolic acid poisoning, pupils are:
A Constricted and pin-point
B Semi-dilated
C Dilated and not responding to li...
Ans. Constricted and Pin- Point Pupil
F = Formaldehyde
B = Barbiturates
.
C =Carbolic Acid
O = Organophosphorus
M = Opium
6.Q. Glass-blowers shakes’ are seen in poisoning due to:
A Lead
B Mercury
C Arsenic
D Copper
Ans. B Mercury
-Donovan solution = Mercury + Arsenic
-MC mercuric salt causing poisoning is = HgCl2
Mu = Minimata Disease
Mmy = Mercuria ...
MINIMATA DISEASE
Minimata disease, is a neurological syndrome caused by severe mercury
poisoning.
Symptoms include ataxia,...
MINIMATA DISEASE
MERCURIA LENTIS
-deposition of brown pigment on anterior lens capsule without affecting
visual acuity.
- Brown malt reflex.
HATTER SHAKE
Tremor (Intentional, coarse, affecting arms, hands, tongue and later legs,
also called hatter's shake/glass b...
Acrodynia (Pink disease, characterised by pain, paraesthesia, pinkish
discolouration of hands and feets)
1) Lead
2) Mercury
3) Iron
4) copper
7.Q. In chronic lead poisoning, there is increased urinary excretion of:
A Coproporphyrin
B Protoporphyrin
C Prophobilinog...
A) Coproporphyrin
LAB PARAMETER VALUES REMARK
1) Coproporphyrin in
Urine
>150mcg/l Exposure to lead
2) Amino Levulinic
Acid in Urine
>5mg/l ...
8.Q. Hippus is seen in which poisoning:
A Abrus
B Aconite
C Alcohol
D Dhatura
Ans. B Aconite
Aconite- late stages Hippus is seen.
-Mitha(sweet) Bish / Mitha zeher
-1st Symptom is : Numbness of tongue
-Roots are poisonous
-Queen of all poisons
- Hippus ...
- Principle : Abrin = similar to Viper’s Venom
Extract from seeds….. Seeds are not poisonous, Only extracts are poisonous
...
-Marking nuts/ bhilawan
-Active principle : Semecarpol
-Juice of seeds produces Artificial Bruise
-Washerman uses it to ma...
9.Q.Antidote in Cyanide poisoning is:
A Sodium thiosulphate
B Silver nitrate
C Sodium calcium edenate
D Sodium bicarbonate
Ans. A Sodium thiosulphate
Cyanide/HCNQ- Amyl nitrite inhaled in handkerchief,
Sodium nitrite i.v. and through the same sy...
HYDROCYANIC ACID
-Also k/a Prussic Acid
-Derived from Linseed Plant
-Bitter almond smell
-Inhibits enzymes of respiratory ...
10) Q. Haematuria occurs from the bite of the:
A Cobra
B Krait
C Sea snake
D Viper
Ans. D Viper
Non-poisonous snake- Semi-circular set of bite marks.
Poisonous snake- 1 or 2 deep fang-marks.
Swallow snake ...
-found mainly in europian countries.
Toxicology 3
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Toxicology 3

  1. 1. - DR.AKIF A.B
  2. 2. 1) A case of poisoning was brought to the casualty, a gastric lavage was done, and the lavage turned black when it was heated after being treated with silver nitrate. The poisoning is most likely to have been due to which of the following? A Tik-20 B Celfos C Malathion D Parathion
  3. 3. Ans. B Celfos Aluminium phosphide- AgNo3 filter paper is turned black by fumes of suspected gastric aspirate containing Phosphine, due to Aluminium Phosphide. Gastric Lavage + Mixed with AgNO3 Heated Black color
  4. 4. -Aluminium phosphide -3gm of celphos liberates 1 gm of phosphene which inhibits cytochrome oxidase and causes respiratory depression. 3gm celphos 1gm phosphene Inhibits Cytochrome Oxidase Causes Respiratory depression
  5. 5. 2.Q. Haemodialysis is mandatory in which poisoning? A Copper sulphate poisoning B Ethanol poisoning C Amphetamine poisoning D Organophosphorus poisoning
  6. 6. Ans. B Ethanol poisoning
  7. 7. B = Barbiturates L = Lithium A = Alcohol S = Salicylates T = Thiophylline/Thiocyanate
  8. 8. HEMODIALYSIS IS C.I in POISONS erosene enzodiaepine hloroquine/CuSO4 eroin
  9. 9. 3.Q. Widmark’s formula is used for measurement of blood levels of: A Benzodiazepines B Barbiturates C Alcohol D Tranquilizers
  10. 10. Ans. ALCOHOL
  11. 11. WIDMARK FORMULA A = P C R Wt. of alcohol Body wt. Conc.of alcohol Constant, Males=0.6 Females= 0.5
  12. 12. -Best method for alcohol estimation = Gas chromatography - Amitabh = Alcohol dehydrogenase -K = Kozelka test -B = Breath analysis test -C = Cavett test Based on Henry’s Law
  13. 13. 4.Q. Which of the following beverages contains the maximum percentage of alcohol: A Whisky B Brandy C Wine D Rum
  14. 14. Ans. D Rum Rum = 50-60% alcohol. Whisky, Gin, Brandy = 40-45%. Port, Sherry = 20%. Wine = 10-15%. Beers = 4-8%.
  15. 15. 5.Q. In carbolic acid poisoning, pupils are: A Constricted and pin-point B Semi-dilated C Dilated and not responding to light D Irregularly shaped
  16. 16. Ans. Constricted and Pin- Point Pupil
  17. 17. F = Formaldehyde B = Barbiturates . C =Carbolic Acid O = Organophosphorus M = Opium
  18. 18. 6.Q. Glass-blowers shakes’ are seen in poisoning due to: A Lead B Mercury C Arsenic D Copper
  19. 19. Ans. B Mercury
  20. 20. -Donovan solution = Mercury + Arsenic -MC mercuric salt causing poisoning is = HgCl2 Mu = Minimata Disease Mmy = Mercuria Lentis H = Hatter Shake E = Erethism A = Acrodynia D = Danbury Tremors - Blue-Black line on gums.
  21. 21. MINIMATA DISEASE Minimata disease, is a neurological syndrome caused by severe mercury poisoning. Symptoms include ataxia, numbness in the hands and feet, general muscle weakness, narrowing of the field of vision and damage to hearing and speech.
  22. 22. MINIMATA DISEASE
  23. 23. MERCURIA LENTIS -deposition of brown pigment on anterior lens capsule without affecting visual acuity. - Brown malt reflex.
  24. 24. HATTER SHAKE Tremor (Intentional, coarse, affecting arms, hands, tongue and later legs, also called hatter's shake/glass blower's shake/danbury tremors) ERETHISM Erethism : Psychological disturbance characterised by shyness, timidness, loss of memory, depression, insomnia.
  25. 25. Acrodynia (Pink disease, characterised by pain, paraesthesia, pinkish discolouration of hands and feets)
  26. 26. 1) Lead 2) Mercury 3) Iron 4) copper
  27. 27. 7.Q. In chronic lead poisoning, there is increased urinary excretion of: A Coproporphyrin B Protoporphyrin C Prophobilinogen D Uroporphyrin
  28. 28. A) Coproporphyrin
  29. 29. LAB PARAMETER VALUES REMARK 1) Coproporphyrin in Urine >150mcg/l Exposure to lead 2) Amino Levulinic Acid in Urine >5mg/l Indicates lead absorption 3) Lead in blood >70mcg/100ml Clinical symptoms appears 4) Lead in urine >0.8mg/l Lead exposure and absorption 5) Basophilic stippling of RBCs Punctate basophilia
  30. 30. 8.Q. Hippus is seen in which poisoning: A Abrus B Aconite C Alcohol D Dhatura
  31. 31. Ans. B Aconite Aconite- late stages Hippus is seen.
  32. 32. -Mitha(sweet) Bish / Mitha zeher -1st Symptom is : Numbness of tongue -Roots are poisonous -Queen of all poisons - Hippus Reaction + : Alternate constriction and dilatation of pupil Also seen with Barbiturates
  33. 33. - Principle : Abrin = similar to Viper’s Venom Extract from seeds….. Seeds are not poisonous, Only extracts are poisonous - Used as Animal poison by needle…also k/a Sin Needle
  34. 34. -Marking nuts/ bhilawan -Active principle : Semecarpol -Juice of seeds produces Artificial Bruise -Washerman uses it to mark clothes.
  35. 35. 9.Q.Antidote in Cyanide poisoning is: A Sodium thiosulphate B Silver nitrate C Sodium calcium edenate D Sodium bicarbonate
  36. 36. Ans. A Sodium thiosulphate Cyanide/HCNQ- Amyl nitrite inhaled in handkerchief, Sodium nitrite i.v. and through the same syringe Sodium thiosulphate i.v., EDTA.
  37. 37. HYDROCYANIC ACID -Also k/a Prussic Acid -Derived from Linseed Plant -Bitter almond smell -Inhibits enzymes of respiratory chain : 1) Carbonic anhydrase 2) superoxide dismutase 3) Cytochrome oxidase 4) Succinate dehydrogenase -Rx: Amyl Nitrite + Vit. B12 + Na. Thiosulphate Triple Antidote Amyl nitrite + CN = Meth-Hb Vit.B12 + CN = Cyanocobalamine Na.thiosulphate +CN= Thiocyanate
  38. 38. 10) Q. Haematuria occurs from the bite of the: A Cobra B Krait C Sea snake D Viper
  39. 39. Ans. D Viper Non-poisonous snake- Semi-circular set of bite marks. Poisonous snake- 1 or 2 deep fang-marks. Swallow snake venom- harmless- as not absorbed by GIT. Most common symptom of snake bite- ‘Fright’. Cobra- Neurotoxic, Cholinesterases; pain & swelling, paralysis, Drooping eyelids(ptosis), larynx edema, coma, convulsions. Krait- Neurotoxic, albuminuria, Cholinesterases; No pain & swelling, drowsiness is more, paralysis, etc, same as for cobra. Viper- Hemolytic, Hburia, pain & swelling, Hburia, unconsciousness, abd. pain, No paralysis. Sea-snakes- Myotoxic, myoglobinuria, pain
  40. 40. -found mainly in europian countries.
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toxicology is a very important topic for pg entrance.....so all about it has been discussed in detail as required for pg entrance....do make use of it...

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