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The pedigree given below has 11 members. Assume that the inbreeding c.pdf

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The pedigree given below has 11 members. Assume that the inbreeding coefficients of the four ancestors (founders) are fA=0.1,fB=0.2,fC=0.3 and fD=0.4. The coancestry coefficients between the four ancestors are AB=0.1,AC=0.2,AD=0.3, BC=0.4,BD=0.5,CD=0.6 (1) Convert the graphical pedigree into a tabular pedigree ( 2 points) (2) Use the tabular method to calculate the coancestry matrix of the 11 members. You cannot use the kinship2 software package to calculate the kinship matrix because kinship2 cannot handle inbred founders. You must use the excel spread sheet to build the matrix. If you wish, you may use PRCO INBREED to validate your result, but you must report your result from the tabular method (8 points)..

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The pedigree given below has 11 members. Assume that the inbreeding coefficients of the four ancestors (founders) are fA=0.1,fB=0.2,fC=0.3 and fD=0.4. The coancestry coefficients between the four ancestors are AB=0.1,AC=0.2,AD=0.3, BC=0.4,BD=0.5,CD=0.6 (1) Convert the graphical pedigree into a tabular pedigree ( 2 points) (2) Use the tabular method to calculate the coancestry matrix of the 11 members. You cannot use the kinship2 software package to calculate the kinship matrix because kinship2 cannot handle inbred founders. You must use the excel spread sheet to build the matrix. If you wish, you may use PRCO INBREED to validate your result, but you must report your result from the tabular method (8 points).

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The pedigree given below has 11 members. Assume that the inbreeding c.pdf

  • 1. The pedigree given below has 11 members. Assume that the inbreeding coefficients of the four ancestors (founders) are fA=0.1,fB=0.2,fC=0.3 and fD=0.4. The coancestry coefficients between the four ancestors are AB=0.1,AC=0.2,AD=0.3, BC=0.4,BD=0.5,CD=0.6 (1) Convert the graphical pedigree into a tabular pedigree ( 2 points) (2) Use the tabular method to calculate the coancestry matrix of the 11 members. You cannot use the kinship2 software package to calculate the kinship matrix because kinship2 cannot handle inbred founders. You must use the excel spread sheet to build the matrix. If you wish, you may use PRCO INBREED to validate your result, but you must report your result from the tabular method (8 points).