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w.pfeiffer@cgiar.org 
Wolfgang H. Pfeiffer 
Developing and Delivering Zinc Wheat: The Role of Wheat in Reducing Hidden Hunger
The 21st Century faces Major Food Security Challenges
Environmental degradation Nitrogen 
Algae growth from fertilizer N 
Sea of Cortez, Mexico 
Source: I. Ortiz-Monasterio
The loss of Genetic Resources
1987 
2003 
A dwindling resources base Water 
Alvaro Obregon Dam Yaqui Valley, Sonora Mexico
2 billion people in the developing world are iron deficient 
Women and children are the 
primary victims 
Micronutrient Deficiency 
Wolfgang H PFEIFFER 
Hidden Hunger 
2 billion+ affected 
Photo: C. Hotz
HarvestPlus - an interdisciplinary, global alliance of more than 200 scientific and implementation partners in over 40 countries that seeks to reduce hidden hunger and provide micronutrients directly through … high-yielding, high-profit varieties of key staple foods that they eat 
HarvestPlus is a joint venture between two CGIAR Centers, the International Center for Tropical Agriculture (CIAT) based in Cali, Colombia and the International Food Policy Research Institute (IFPRI) based in Washington, D.C. 
addressed by
What can We do now? 
•Diversify the diet 
expensive & out of reach for many 
•Fortify Food e.g. with iron, iodine 
need access to the market - buy processed food 
•Provide Supplements e.g. vitamin A, iron, zinc 
need access to the health care system - high delivery cost
What can Biofortification do? 
•Develop wheat, rice, maize, cassava and other staples packed with additional vitamins or minerals…. 
•Nutritional benefits coming from the crops, harvest after harvest, with no additional costs 
•Reach those who are not reached by other nutrition interventions
HarvestPlus Impact & Product Pathway 
Development of Crop Product Concepts 
Discovery: HPlus I 2004-2008 
Determine Cost /Benefit compared to other Interventions 
Identify Target Populations & Staple food consumption 
Setting Nutrient Target Levels 
Screening & Determine Breeding Feasibility
Initial Target Areas for Zinc dense Wheat 
Baseline Micronutrient Level in Commercial Crop 25 μgg-1 
Target Increment to be added 
12 μgg-1 
ME1: Temperate Irrigated High Production NWPZ 
ME5: Irrigated High Temperate Stress EGPZ
% of Physiologic Requirement1) for Zinc achieved by different Levels of +12ppm Zinc Wheat Intake 
Consumed g/day 
% Requirement 
1) Woman in child bearing age
Genetic Variation for Zinc & Iron in Wheat 
Iron μgg-1 
Zinc μgg-1 
Variation to surpass the target in wild relative species & synthetic wheat 
+ 
Lack of genetic variation in adapted, high yielding genotypes 
-
Cakmak et al., 2009 
Endosperm 
Aleurone 
Embryo 
High Zinc Wheat 
Low Zinc 
Co-localization 
Protein 
Zinc 
Iron 
Amino Acids
HarvestPlus Impact & Product Pathway 
Nutrition Retention and Bioavailability 
Nutritional Efficacy Studies on Human Subjects 
Crop Development 
Development: HPlus II 2009-2013 
GxE Performance Testing in Target Countries
HarvestPlus Impact & Product Pathway 
Release C 
Seed Production Launch | Test Marketing 
Delivery: HPlus III 2014 - 2018 
Advocacy 
Delivery | Commercialization Marketing 
Awareness | Demand Creation Acceptability Studies 
Market & Product Development 
Shakti man
Q #1: Can breeding increase nutrients to levels that improve nutrition? 
Will Biofortification Work?
Cassava 
Vitamin A 
Nigeria & DRC 
Beans 
Iron 
Rwanda & DRC 
Maize 
Vitamin A 
Zambia 
Release Dates for Crops for Africa & Asia 
2007 
Sweetpotato 
Vitamin A 
Uganda 
Pearl Millet Iron 
India 
Rice 
Zinc 
Bangladesh 
Wheat 
Zinc 
India | Pakistan 2015 
2013 
2012 
2013 
2012 
2011 
2013 
2012
Biofortified crops released in 27 countries 
18 in Africa, 4 in Asia, 5 in LAC 
In-testing in 43 countries 
26 in Africa, 8 in Asia, 9 in LAC 
4 Vita-A , 5 Iron , 4 Zinc Crops 
Sorghum 
Banana Plantain 
Cowpea 
Potato 
Lentil
Q #2: Are the extra nutrients bioavailable at sufficient levels to improve micronutrient status? 
Will Biofortification Work?
How do we know zinc wheat works? 
2008 - 
2011 
2009 - 
2010 
2014 - 
2015 
Sangam Vihar, New Delhi Bangalore 
Children 4-6 years & 
Women in child bearing age 
School children in Bangalore 
n=1500 women & 1500 children 
per group x 2 groups 
n=150 per group x 3 groups 
New Delhi; JHU & Subhart i Medical 
College 
ETH & St . John’s Medical College 
Zinc wheat contributes a significant proportion of the Zinc EAR in 
the target population P 
Zinc in biofortified wheat is bioavailable,absorbed and utilized P 
Does zinc wheat consumption improve zinc status of women and 
children?
Q #3: Will farmers adopt zinc wheat and will consumers buy & eat in sufficient quantities? 
Will Biofortification Work?
> 1.5 million farming households reached 2011 - 2013 
> 7.5 million farming household members consuming 
Delivery / Commercialization 
> 1.1 million farming households targeted in 2014
Crop Development , Testing & Commercialization Partnership 
Public Sector: DWR – (ICAR) IARI - Delhi PAU - Ludhiana BHU - Varanasi CIMMYT 
Private Sector: 
Ankur Seeds, Ajeet Seeds, 
Astha Beej Ltd, Bayer Crop Science, DCM Shriram Ltd., Krishidhan, Mahyco, Nirmal Seeds, Nuziveedu Seeds, Pantnagar Tarai Agri Seeds, Rasi Seeds, Shakati Vardhak, Sri Sai Seeds, Shriyanshi Seeds
What is the Way Forward? 
Photo: Neil Palmer (CIAT)
HarvestPlus III will demonstrate the viability of biofortification as a global solution and lay foundation for scale by 
HarvestPlus III 2014-2018 Strategic Priorities 
Research, communicate and advocate strategically 
Strengthen the pipeline of biofortified varieties 
Scale up delivery in target countries and expand delivery to new countries
HarvestPlus Phase III Strategic Priorities 
Scale up delivery in target countries and expand delivery to new countries 
Target Countries 
•Implement country level business plans 
Expansion Countries 
•Scale up delivery of prioritized crops in target geographies through partnerships 
•Develop & deploy technical assistance capabilities to support partnerships
Quick Assessment of the Relative Role/Value of Main Partner Groups
Breed competitive crops to target nutrient levels and broader applicability across agro-ecological zones & uses 
Molecular markers & diagnostic tool development 
Zinc as core trait / non- negotiable trait → endorsed by CG-Center DGs 
Anti-nutrients & promoters Phytate / Phytase … 
Strengthen the pipeline of biofortified varieties 
•Successfully develop next waves of crops 
•Enhance knowledge base & deliver improved enabling technologies 
•Mainstream biofortification 
•Improve bioavailability of zinc and iron 
HarvestPlus Phase III Strategic Priorities
Thank You!
Wheat India – Eastern Gangetic Plains Zone 
Test marketing of 5 zinc wheat leads - 1000 mini- kits in 2013 -2014; additional leads are in testing

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ROLE OF ZINCATED WHEAT IN REDUCING HUNGER-DR MUHAMMAD ANJUM ALI

  • 1. w.pfeiffer@cgiar.org Wolfgang H. Pfeiffer Developing and Delivering Zinc Wheat: The Role of Wheat in Reducing Hidden Hunger
  • 2. The 21st Century faces Major Food Security Challenges
  • 3. Environmental degradation Nitrogen Algae growth from fertilizer N Sea of Cortez, Mexico Source: I. Ortiz-Monasterio
  • 4. The loss of Genetic Resources
  • 5. 1987 2003 A dwindling resources base Water Alvaro Obregon Dam Yaqui Valley, Sonora Mexico
  • 6. 2 billion people in the developing world are iron deficient Women and children are the primary victims Micronutrient Deficiency Wolfgang H PFEIFFER Hidden Hunger 2 billion+ affected Photo: C. Hotz
  • 7. HarvestPlus - an interdisciplinary, global alliance of more than 200 scientific and implementation partners in over 40 countries that seeks to reduce hidden hunger and provide micronutrients directly through … high-yielding, high-profit varieties of key staple foods that they eat HarvestPlus is a joint venture between two CGIAR Centers, the International Center for Tropical Agriculture (CIAT) based in Cali, Colombia and the International Food Policy Research Institute (IFPRI) based in Washington, D.C. addressed by
  • 8. What can We do now? •Diversify the diet expensive & out of reach for many •Fortify Food e.g. with iron, iodine need access to the market - buy processed food •Provide Supplements e.g. vitamin A, iron, zinc need access to the health care system - high delivery cost
  • 9. What can Biofortification do? •Develop wheat, rice, maize, cassava and other staples packed with additional vitamins or minerals…. •Nutritional benefits coming from the crops, harvest after harvest, with no additional costs •Reach those who are not reached by other nutrition interventions
  • 10. HarvestPlus Impact & Product Pathway Development of Crop Product Concepts Discovery: HPlus I 2004-2008 Determine Cost /Benefit compared to other Interventions Identify Target Populations & Staple food consumption Setting Nutrient Target Levels Screening & Determine Breeding Feasibility
  • 11. Initial Target Areas for Zinc dense Wheat Baseline Micronutrient Level in Commercial Crop 25 μgg-1 Target Increment to be added 12 μgg-1 ME1: Temperate Irrigated High Production NWPZ ME5: Irrigated High Temperate Stress EGPZ
  • 12. % of Physiologic Requirement1) for Zinc achieved by different Levels of +12ppm Zinc Wheat Intake Consumed g/day % Requirement 1) Woman in child bearing age
  • 13. Genetic Variation for Zinc & Iron in Wheat Iron μgg-1 Zinc μgg-1 Variation to surpass the target in wild relative species & synthetic wheat + Lack of genetic variation in adapted, high yielding genotypes -
  • 14. Cakmak et al., 2009 Endosperm Aleurone Embryo High Zinc Wheat Low Zinc Co-localization Protein Zinc Iron Amino Acids
  • 15. HarvestPlus Impact & Product Pathway Nutrition Retention and Bioavailability Nutritional Efficacy Studies on Human Subjects Crop Development Development: HPlus II 2009-2013 GxE Performance Testing in Target Countries
  • 16. HarvestPlus Impact & Product Pathway Release C Seed Production Launch | Test Marketing Delivery: HPlus III 2014 - 2018 Advocacy Delivery | Commercialization Marketing Awareness | Demand Creation Acceptability Studies Market & Product Development Shakti man
  • 17. Q #1: Can breeding increase nutrients to levels that improve nutrition? Will Biofortification Work?
  • 18. Cassava Vitamin A Nigeria & DRC Beans Iron Rwanda & DRC Maize Vitamin A Zambia Release Dates for Crops for Africa & Asia 2007 Sweetpotato Vitamin A Uganda Pearl Millet Iron India Rice Zinc Bangladesh Wheat Zinc India | Pakistan 2015 2013 2012 2013 2012 2011 2013 2012
  • 19. Biofortified crops released in 27 countries 18 in Africa, 4 in Asia, 5 in LAC In-testing in 43 countries 26 in Africa, 8 in Asia, 9 in LAC 4 Vita-A , 5 Iron , 4 Zinc Crops Sorghum Banana Plantain Cowpea Potato Lentil
  • 20. Q #2: Are the extra nutrients bioavailable at sufficient levels to improve micronutrient status? Will Biofortification Work?
  • 21. How do we know zinc wheat works? 2008 - 2011 2009 - 2010 2014 - 2015 Sangam Vihar, New Delhi Bangalore Children 4-6 years & Women in child bearing age School children in Bangalore n=1500 women & 1500 children per group x 2 groups n=150 per group x 3 groups New Delhi; JHU & Subhart i Medical College ETH & St . John’s Medical College Zinc wheat contributes a significant proportion of the Zinc EAR in the target population P Zinc in biofortified wheat is bioavailable,absorbed and utilized P Does zinc wheat consumption improve zinc status of women and children?
  • 22. Q #3: Will farmers adopt zinc wheat and will consumers buy & eat in sufficient quantities? Will Biofortification Work?
  • 23. > 1.5 million farming households reached 2011 - 2013 > 7.5 million farming household members consuming Delivery / Commercialization > 1.1 million farming households targeted in 2014
  • 24. Crop Development , Testing & Commercialization Partnership Public Sector: DWR – (ICAR) IARI - Delhi PAU - Ludhiana BHU - Varanasi CIMMYT Private Sector: Ankur Seeds, Ajeet Seeds, Astha Beej Ltd, Bayer Crop Science, DCM Shriram Ltd., Krishidhan, Mahyco, Nirmal Seeds, Nuziveedu Seeds, Pantnagar Tarai Agri Seeds, Rasi Seeds, Shakati Vardhak, Sri Sai Seeds, Shriyanshi Seeds
  • 25. What is the Way Forward? Photo: Neil Palmer (CIAT)
  • 26. HarvestPlus III will demonstrate the viability of biofortification as a global solution and lay foundation for scale by HarvestPlus III 2014-2018 Strategic Priorities Research, communicate and advocate strategically Strengthen the pipeline of biofortified varieties Scale up delivery in target countries and expand delivery to new countries
  • 27. HarvestPlus Phase III Strategic Priorities Scale up delivery in target countries and expand delivery to new countries Target Countries •Implement country level business plans Expansion Countries •Scale up delivery of prioritized crops in target geographies through partnerships •Develop & deploy technical assistance capabilities to support partnerships
  • 28. Quick Assessment of the Relative Role/Value of Main Partner Groups
  • 29. Breed competitive crops to target nutrient levels and broader applicability across agro-ecological zones & uses Molecular markers & diagnostic tool development Zinc as core trait / non- negotiable trait → endorsed by CG-Center DGs Anti-nutrients & promoters Phytate / Phytase … Strengthen the pipeline of biofortified varieties •Successfully develop next waves of crops •Enhance knowledge base & deliver improved enabling technologies •Mainstream biofortification •Improve bioavailability of zinc and iron HarvestPlus Phase III Strategic Priorities
  • 31.
  • 32. Wheat India – Eastern Gangetic Plains Zone Test marketing of 5 zinc wheat leads - 1000 mini- kits in 2013 -2014; additional leads are in testing